|(2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-羟基-3-((2R,5S)-5-(2-羟基丙-2-基)-2-甲基四氢呋喃-2-基)-2a,5a,8,8-四甲基-9-(((2S,3R,4S,5R)-3,4,5-三羟基四氢-2H-吡喃-2-基)氧基)十四氢-1H,12H-环戊二烯并[a]环丙并[e]菲-7-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 84687-43-4

Astragaloside IV/黄芪甲苷 Catalog No. CSN13512

Synonyms: AST-IV;AS-IV;黄芪皂苷 IV

Astragaloside IV, an active component isolated fromAstragalus membranaceus, suppresses the activation ofERK1/2andJNK/b> , and downregulates matrix metalloproteases (MMP)-2, (MMP)-9in MDA-MB-231 breast cancer cells.

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技术信息

生物活性

描述Astragaloside IV(AS-IV) is a saponin from Astragalus membranaceus. Oral administration of AS-IV (10 and 20 mg/kg) significantly attenuated memory impairment and neuroinflammation^[3]. High-dose astragaloside IV has a significant protective effect against D-GalN/LPS-induced (D-galactosamine/lipopolysaccharide-induced ) acute liver injury in mice ^[4]. High doses of astragaloside IV (10, 20, 40 ng/ml) inhibited NSCLC (non-small cell lung cancer ) cell growth^[5]. Astragaloside IV inhibited the viability and invasive potential of MDA-MB-231 breast cancer cells, suppressed the activation of the mitogen activated protein kinase (MAPK) family members ERK1/2 and JNK, and downregulated matrix metalloproteases (MMP)-2 and -9^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01553643	Intracranial Arterial Stenosis	Phase 4	Unknown	-	Taiwan ... more >> China Medical University Hospital Recruiting Taiching, Taiwan Contact: Chung Hsiang Liu, MD. Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2739 mL
- 6.3697 mL
- 12.7393 mL
- 5 mM
- 0.2548 mL
- 1.2739 mL
- 2.5479 mL
- 10 mM
- 0.1274 mL
- 0.6370 mL
- 1.2739 mL

技术信息

CAS号

84687-43-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C41H68O14

运输

蓝冰

分子量

784.97

别名

AST-IV;AS-IV;黄芪皂苷 IV;黄芪甲苷

溶解度

DMSO	40.0 mg/mL (51.0 mM)
Water	insoluble

动物实验配方

PO	5%DMSO + 30%PEG400 + 1%tween80 + 64%Water	2 mg/mL	clear
PO	10%DMSO+ SBE-β-CD water solution (20%)	2 mg/mL	clear

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