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CAS No.: 84676-89-1

Astragaloside II/黄芪皂苷 II Catalog No. CSN16478

Synonyms: Astrasieversianin VIII;黄芪皂苷 II

Astragaloside II is a natural isolated from Astragalus.

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纯度 & 质量文件批次:

靶点选择性

生物活性

描述Astragaloside II (AS II), a novel saponin purified from Astragalus membranes, can modulate the immune response, repair tissue injury, and prevent inflammatory response. AS II (3.2 and 6.4 mg·kg-1·d-1) ameliorated podocyte injury and mitochondrial dysfunction in diabetic rats partly through regulation of Nrf2 and PINK1 pathway^[3]. AS II could alleviate inflammatory response in LPS-induced CCD-18Co cells and in DSS(dextran sulfate sodium)-induced UC (Ulcerative colitis) in mice^[4]. Astragaloside II (10 and 30 nmol/L) significantly enhanced the proliferation of primary splenocytes induced by ConA, alloantigen or anti-CD3. Astragaloside II (30 nmol/L) significantly increased IL-2 and IFN-γ secretion, upregulated the mRNA levels of IFN-γ a nd T-bet in primary splenocytes, and promoted CD25 and CD69 expression on primary CD4(+) T cells upon TCR stimulation. Furthermore, astragaloside II (100 nmol/L) promoted CD45-mediated dephosphorylation of LCK (Tyr505) in primary T cells, which could be blocked by a specific CD45 PTPase inhibitor^[5]. AS II promoted wound closure and increased cell proliferation, L-arginine uptake, CAT1 and CAT2 protein levels, total protein synthesis, and phosphorylation of mTOR, S6K, and 4E-BP1 in Caco-2 cells^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2092 mL
- 6.0459 mL
- 12.0918 mL
- 5 mM
- 0.2418 mL
- 1.2092 mL
- 2.4184 mL
- 10 mM
- 0.1209 mL
- 0.6046 mL
- 1.2092 mL

技术信息

CAS号

84676-89-1

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C43H70O15

运输

蓝冰

分子量

827.01

别名

Astrasieversianin VIII;黄芪皂苷 II

溶解度

DMSO	95.0 mg/mL (114.9 mM) warming
Water	Insoluble

动物实验配方

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总药量计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 动物数量只每天给药次给药天

需要的总药量：mg

工作液计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 给药体积μL

您需要配制的工作液浓度为：mg/mL

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