|5,7-二羟基-2-(4-羟基苯基)-3-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 480-10-4

Astragaline/紫云英苷 Catalog No. CSN10347

Synonyms: Astragaline;3-Glucosylkaempferol;Kaempferol 3-β-D-glucopyranoside

Astragalin is a flavonoid isolated and purified from the leaves of Nelumbo nucifera Gaertn. with anti-inflammatory activity.

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400-920-2911

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技术信息

生物活性

描述Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity and newly found in persimmon leaves and green tea seeds. When airway epithelial cells were exposed to 2 μg/ml LPS, astragalin nontoxic at ≤ 20 μM suppressed cellular induction of Toll-like receptor 4 (TLR4) and ROS production enhanced by LPS. Astragalin ameliorated oxidative stress-associated epithelial eosinophilia and apoptosis through disturbing TLR4-PKCβ2-NADPH oxidase-responsive signaling^[3]. AG (Astragalin) treatment reduced weight loss and the disease activity index (DAI), prevented colon shortening and alleviated colonic tissue damage. AG treatment reduced the expression of pro-inflammatory cytokines and related mRNAs (such as TNF-α, IL-6, and IL-1β), inhibited colonic infiltration by macrophages and neutrophils, ameliorated metabolic endotoxemia, and improved intestinal mucosal barrier function (increased expression levels of mRNAs such as ZO-1, occludin, and Muc2)^[4]. Astragalin exerted an anti-inflammatory effect through NF-κB pathway inhibition and attenuated murine colitis^[5]. Astragalin exerts anti-inflammatory properties possibly via the inactivation of TLR4-mediated NF-κB and mitogen-activated protein kinases signaling pathways in LPS-stimulated mMECs (mouse mammary epithelial cells)^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2303 mL
- 11.1513 mL
- 22.3027 mL
- 5 mM
- 0.4461 mL
- 2.2303 mL
- 4.4605 mL
- 10 mM
- 0.2230 mL
- 1.1151 mL
- 2.2303 mL

技术信息

CAS号

480-10-4

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H20O11

运输

蓝冰

分子量

448.38

别名

Astragaline;3-Glucosylkaempferol;Kaempferol 3-β-D-glucopyranoside;Kaempferol 3-beta-D-glucopyranoside;Kaempferol-3-glucoside;K5;Kaempferol-3-beta-glucopyranoside;Kaempferol-3-beta-monoglucoside;Kaempferol-3-O-glucoside;UNII-APM8UQ3Z9O;紫云英苷

溶解度

DMSO	90.0 mg/mL (200.7 mM)

动物实验配方

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