|(R)-2-丙基辛酸|CsnPharm

CAS No.: 185517-21-9

Arundic Acid/(R)-2-丙基辛酸 Catalog No. CSN25446

Synonyms: (R)-2-Propyloctanoic acid;Arocyte;Cereact

Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid (ONO-2506) has been developed as a therapeutic agent for stroke and Alzheimer's disease.

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描述ONO-2506 is an astrocyte-modulating agent that suppresses astrocyte activation via inhibiting the synthesis of S-100β and thereby delaying the expansion of cerebral infarcts. It exhibits therapeutic potential for stroke and Alzheimer's disease^[1]. ONO-2506 at concentrations between 30 to 300mmol/L significantly inhibited the mRNA expression and decreased the intracellular levels of S-100β. Repeated intravenous injection with ONO-2506 (50mg/kg) for 4 weeks induced inflammatory responses at the injection site and transient ataxic gait in both rats and dogs^[3]. In a mouse model of MPTP-induced Parkinson's disease, treatment with ONO-2506 (30mg/kg, i.p.) at 1min, 6h, 24h, 48h, and 72h after the last MPTP injection prevented dopamine depletion and the appearance of motor abnormalities in behavioral tests. Compared to mice injected with MPTP alone, ONO-2506 administration increased tyrosine hydroxylase-containing dopaminergic neurons in the substantia nigra (87% reduction vs. 56% reduction). ONO-2506 treatment also induced an earlier appearance of reactive astrocytes by three days and suppressed the expression of S-100β in MPTP-injected mice^[4].
参考文献

[1] Haasegawa, T., Kawanaka, Y., Kasamatsu, E. et al. Process Development of ONO-2506: A Therapeutic Agent for Stroke and Alzheimer's Disease. Org. Proc. Res. Dev. 2003, 7((2): 168-171.
[2] Kato H, et al. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTPneurotoxicity in mice. Brain Res. 2004 Dec 24;1030(1):66-73.
[3] Asano T, Mori T, Shimoda T, et al. Arundic acid (ONO-2506) ameliorates delayed ischemic brain damage by preventing astrocytic overproduction of S100B. Curr Drug Targets CNS Neurol Disord. 2005;4(2):127-142.
[4] Kato H, Kurosaki R, Oki C, Araki T. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTP neurotoxicity in mice. Brain Res. 2004;1030(1):66-73.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.3679 mL
- 26.8397 mL
- 53.6794 mL
- 5 mM
- 1.0736 mL
- 5.3679 mL
- 10.7359 mL
- 10 mM
- 0.5368 mL
- 2.6840 mL
- 5.3679 mL

技术信息

CAS号	185517-21-9	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C11H22O2	运输	蓝冰
分子量	186.29	别名	(R)-2-Propyloctanoic acid;Arocyte;Cereact;MK-0724;Proglia;ONO-2506

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