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CAS No.: 141396-28-3

Argatroban monohydrate/阿加曲班一水合物 Catalog No. CSN10332

Synonyms: MD-805 monohydrate;MCI-9038 monohydrate;Argipidine monohydrate

Argatroban is an inhibitor of thrombin.

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技术信息

生物活性

描述Argatroban Monohydrate is a direct thrombin inhibitor synthesised to bind to the catalytic site of the thrombin molecule. It binds rapidly and reversibly to both clot-bound and soluble thrombin. Argatroban produces a predictable dose response that is well correlated with changes in anticoagulant parameters^[3]. Argatroban may have a complementary effect for preventing thrombus formation without aggravating bleeding tendency because of its monotarget specificity to thrombin. Intravenous administration (0.5 to 2 micrograms/kg/min) of argatroban is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries^[4]. Argatroban, as compared with heparin, appears to enhance reperfusion with TPA (tissue plasminogen activator) in patients with AMI (acute myocardial infarction), particularly in those patients with delayed presentation^[5]. Intravenous argatroban improved clinical outcomes and was generally well tolerated in adults with HIT (heparin-induced thrombocytopenia) or HIT with thrombosis syndrome (HITTS). Argatroban was safe and effective for improving short and long-term outcomes in noncardioembolic stroke patients^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8988 mL
- 9.4940 mL
- 18.9880 mL
- 5 mM
- 0.3798 mL
- 1.8988 mL
- 3.7976 mL
- 10 mM
- 0.1899 mL
- 0.9494 mL
- 1.8988 mL

技术信息

CAS号

141396-28-3

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H38N6O6S

运输

蓝冰

分子量

526.65

别名

MD-805 monohydrate;MCI-9038 monohydrate;Argipidine monohydrate;MCI-9038;MD-805;DK-7419;GN-1600;MMTQAP;MPQA;Argatroban.Novastan;OM 805;Slonnon;Argipidine;阿加曲班一水合物

溶解度

DMSO	98.0 mg/mL (186.1 mM)
Water	Insoluble
Ethanol	40.0 mg/mL (76.0 mM)

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