CAS No.: 2166548-12-3
AR-13324 mesylate Catalog No. CSN17830
Synonyms: Netarsudil Mesylate
AR-13324 mesylate is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter which inhibits kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 ROCK1
Ki:1 nMROCK2
IC50:1 nM- 描述
动物研究 剂量 Rat: 7 mg/kg[3] (i.v.)
给药途径 i.v.
- 参考文献
- [1] Kiel JW, Kopczynski CC. Effect of AR-13324 on episcleral venous pressure in Dutch belted rabbits. J Ocul Pharmacol Ther. 2015 Apr;31(3):146-51.
- [2] Wang RF, Williamson JE, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-4.
- [3] Netarsudil mesylate
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 2166548-12-3 | 储存条件 |
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| 分子式 | C29H31N3O6S | 运输 | 蓝冰 | |
| 分子量 | 549.64 | 别名 | Netarsudil Mesylate |
