|(2R,3R,4S,5S,6S)-5-氨基-2-(((2R,3S,4R,4aR,6S,7R,8aS)-7-氨基-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)-4-二氨基-2,3-二羟环己基)氧基)-4-羟基-3-（甲胺基）八氢吡喃并[3,2-b]吡喃-2-基）氧基）-6-（羟甲基）四氢-2H-吡喃-3,4-二醇x硫酸盐|CsnPharm

CAS No.: 65710-07-8

Apramycin Sulfate/硫酸阿布拉霉素 Catalog No. CSN18883

Synonyms: Nebramycin II sulfate;Ai3-29795(1:x);Nebramycin-II(1:x)

Apramycin sulfate(1:x) is an aminoglycoside antibiotic mproduced by a strain of Streptomyces tenebrarius, used in veterinary practice.

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生物活性

描述Apramycin Sulfate(1:x) is an aminocyclitol aminoglycoside with broad-spectrum in vitro activity against MDR Gram-negative pathogens and Staphylococcus aureus. Apramycin has broad-spectrum, rapidly bactericidal activity against N. gonorrhoeae^[3]. Apramycin demonstrated an MIC50/MIC90 of 8/32μg/ml for A. baumannii and 16/32μg/ml for P. aeruginosa. Apramycin appears to offer promising in vitro activity against highly resistant pathogens^[4]. Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum (Cmax)/MIC was ≈10 or higher^[5]. Prior to treatment apramycin-resistant Escherichia coli were present but all S. typhimurium isolates were sensitive. Following the treatment of six calves with apramycin, apramycin-resistant S. typhimurium were isolated from two treated calves and one untreated calf^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5682 mL
- 7.8412 mL
- 15.6824 mL
- 5 mM
- 0.3136 mL
- 1.5682 mL
- 3.1365 mL
- 10 mM
- 0.1568 mL
- 0.7841 mL
- 1.5682 mL

技术信息

CAS号

65710-07-8

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H43N5O15S

运输

蓝冰

分子量

637.66

别名

Nebramycin II sulfate;Ai3-29795(1:x);Nebramycin-II(1:x);Apramycin (sulfate);Apramycin sulphate;硫酸安普霉素;硫酸安普霉素(1:x)

溶解度

DMSO	Insoluble
Water	98.0 mg/mL (153.7 mM)
Ethanol	Insoluble

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