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CAS No.: 5108-96-3

吡咯烷二硫代氨基甲酸铵 Catalog No. CSN17286

Synonyms: Ammonium pyrrolidinedithiocarbamate;PDTC ammonium;APDC

Ammonium pyrrolidine-1-carbodithioate is a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.

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实验方案

技术信息

生物活性

描述NF-κB is a transcription factor with heterodimer or homodimer form of rel family proteins including RelA (p65), RelB, cRel, p50 and p52. Ammonium Pyrrolidine-1-Carbodithioate, also called as PDTC, can potently and selectively block the activation of NF-κB. Pre-treatment with PDTC at concentration ranging in 0.01-0.1mM for 1.5h could dose-dependently inhibited the binding of NF-κB with DNA induced by TNF in Jurkat T cells (However, the inhibitory effect decreased at concentration>1mM) . The IL-1β-stimulated nitrite production could be suppressed dose-dependently by PDTC at concentration ranging in 30-100μM for 20h in rat renal mesangial cells. And also the increased NOS mRNA responsible for IL-1β could be suppressed completely by PDTC in the same cells. PDTC at concentration of 40μM caused decrease in the proliferation of cultured mouse breast cancer (E0771) cells by 60%. Oral administration of PDTC at dose around 100 to 200 mg/kg/day (in drinking water) for 3 weeks could significantly reduce breast cancer growth in mice bearing E0771 cells, with slight reduction of microvessel density and VEGF expression in tumor tissue.
动物研究
剂量
Mice: 0.5 mg/kg - 3.0 mg/kg^[3] (i.p.), 100 mg/kg - 200 mg/kg (p.o.) Rat: 50 mg/kg - 200 mg/kg^[4] (p.o.)

给药途径
i.p., p.o.
参考文献

动物研究
剂量	Mice: 0.5 mg/kg - 3.0 mg/kg^[3] (i.p.), 100 mg/kg - 200 mg/kg (p.o.) Rat: 50 mg/kg - 200 mg/kg^[4] (p.o.)
给药途径	i.p., p.o.

[1] Rae C, Langa S, et al. Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12790-5.
[2] Klampfer L, Cammenga J, et al. Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines. Blood. 1999 Apr 1;93(7):2386-94.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.0868 mL
- 30.4340 mL
- 60.8680 mL
- 5 mM
- 1.2174 mL
- 6.0868 mL
- 12.1736 mL
- 10 mM
- 0.6087 mL
- 3.0434 mL
- 6.0868 mL

技术信息

CAS号

5108-96-3

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C5H12N2S2

运输

蓝冰

分子量

164.29

别名

Ammonium pyrrolidinedithiocarbamate;PDTC ammonium;APDC;1-Pyrrolidinedithiocarboxylic Acid Ammonium Salt;Pyrrolidinedithiocarbamic Acid (ammonium salt);PDTC;Pyrrolidinedithiocarbamate;Ammonium 1-Pyrrolidinecarbodithioate. PDTC. APDC.;MUN-08963;吡咯烷二硫代氨基甲酸铵

溶解度

DMSO	138.0 mg/mL (840.0 mM)
Water	insoluble

动物实验配方

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吡咯烷二硫代氨基甲酸铵 Catalog No. CSN17286

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