CAS No.: 880549-30-4
AMD-070 hydrochloride Catalog No. CSN13824
Synonyms: AMD-070;X4P-001;mavorixafor
AMD-070 HCl is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Skerlj R, Bridger G, et al. Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1414-8.
- [2] Skerlj RT, Bridger GJ, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 880549-30-4 | 储存条件 |
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| 分子式 | C21H28ClN5 | 运输 | 蓝冰 | |
| 分子量 | 385.93 | 别名 | AMD-070;X4P-001;mavorixafor;Mavorixafor HCl;Mavorixafor trihydrochloride |
