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CAS No.: 156053-89-3
Synonyms: ADL 8-2698;LY 246736;HSDB-7704
Alvimopan is a peripherally selective opioid mu receptor antagonist.
生物活性
靶点 | Opioid Receptor μ IC50:1.7nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT02109640 | Postoperative Pain ... more >> Postoperative Nausea and Vomiting Collapse << | Phase 3 | Completed | - | United Kingdom ... more >> Western General Hospital Edinburgh, United Kingdom, EH4 2XU Collapse << |
NCT02109640 | - | - | Completed | - | - |
NCT00388479 | Ileus | Phase 3 | Completed | - | United States, Pennsylvania ... more >> Various Exton, Pennsylvania, United States, 19341 Collapse << |
实验方案
技术信息
CAS号 | 156053-89-3 | 储存条件 |
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分子式 | C25H32N2O4 | 运输 | 蓝冰 | |||||||
分子量 | 424.53 | 别名 | ADL 8-2698;LY 246736;HSDB-7704;爱维莫潘 | |||||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT02109640 | Postoperative Pain ... more >> Postoperative Nausea and Vomiting Collapse << | Phase 3 | Completed | - | United Kingdom ... more >> Western General Hospital Edinburgh, United Kingdom, EH4 2XU Collapse << |
NCT02109640 | - | - | Completed | - | - |
NCT00388479 | Ileus | Phase 3 | Completed | - | United States, Pennsylvania ... more >> Various Exton, Pennsylvania, United States, 19341 Collapse << |
NCT02785003 | Acute Pain Pa... more >>in, Postoperative Colorectal Surgery Collapse << | Phase 4 | Withdrawn(Lack of Funding) | August 2018 | United States, Wisconsin ... more >> Froedtert Memorial Lutheran Hospital Milwaukee, Wisconsin, United States, 53226 Collapse << |
NCT00101998 | Constipation ... more >>Bowel Dysfunction Collapse << | Phase 2 | Completed | - | - |
NCT00388258 | Ileus | Phase 3 | Completed | - | United States, Pennsylvania ... more >> Various Exton, Pennsylvania, United States, 19341 Collapse << |
NCT00388401 | Ileus | Phase 3 | Completed | - | United States, Pennsylvania ... more >> Adolor Corporation Exton, Pennsylvania, United States, 19341 Collapse << |
NCT00331045 | Cancer Consti... more >>pation Collapse << | Phase 2 | Terminated(Subject registratio... more >>n did not proceed as expected; difficult to complete within scheduled time frame; prematurely terminated w/ 21 subjects randomized.) Collapse << | - | - |
NCT01704651 | Ovarian Cancer ... more >> Fallopian Tube Cancer Peritoneal Cancer Collapse << | Phase 3 | Completed | - | United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
NCT00241722 | Bowel Dysfunction ... more >> Constipation Collapse << | Phase 3 | Completed | - | - |
NCT01704651 | - | - | Completed | - | - |
NCT00205842 | Ileus | Phase 3 | Completed | - | United States, Pennsylvania ... more >> 50 Sites Exton, Pennsylvania, United States, 19341 Collapse << |
NCT00135577 | Cancer Bowel ... more >>Dysfunction Collapse << | Phase 2 | Completed | - | - |
NCT00256932 | Bowel Dysfunction ... more >> Constipation Collapse << | Phase 3 | Completed | - | - |
NCT00259922 | Bowel Dysfunction ... more >> Constipation Collapse << | Phase 3 | Completed | - | - |
NCT02379858 | Ventral Hernia | Not Applicable | Recruiting | July 2022 | United States, Wisconsin ... more >> Froedtert & the Medical College of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Matthew I Goldblatt, MD 414-955-1770 mgoldbla@mcw.edu Contact: Melissa C Helm, MSN, RN 414-955-1775 mhelm@mcw.edu Sub-Investigator: Andrew S Kastenmeier, MD Sub-Investigator: Cathyyen Dang, PharmD, BCPS Collapse << |
NCT01258569 | Laparoscopic Colonic Resection | Phase 2 | Completed | - | United States, Connecticut ... more >> Hartford Hospital Hartford, Connecticut, United States, 06102-5037 Collapse << |
NCT00708201 | Postoperative Ileus | Phase 4 | Completed | - | United States, California ... more >> Saddleback Memorial Medical Center Laguna Hills, California, United States, 92653 United States, Colorado University of Colorado Hospital Aurora, Colorado, United States, 80045 United States, Florida University of Miami Miami, Florida, United States, 33136 H. Lee Moffitt Cancer Center & Research Institute Tampa, Florida, United States, 33612 United States, Illinois The University of Chicago Medical Center Chicago, Illinois, United States, 60637 University of Chicago, Section of Urology MC6038 Chicago, Illinois, United States, 60637 United States, Indiana Indiana University Hospital Indianapolis, Indiana, United States, 46202 United States, Louisiana Ochsner Clinic Foundation New Orleans, Louisiana, United States, 70121 United States, Michigan University of Michigan Health System Ann Arbor, Michigan, United States, 48109 United States, Minnesota University of Minnesota Hospital Minneapolis, Minnesota, United States, 55455 Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Mississippi CRC of Jackson Jackson, Mississippi, United States, 39202 United States, North Carolina University of North Carolina Hospitals Chapel Hill, North Carolina, United States, 27599 Wake Forest University Baptist Medical Center Winston-Salem, North Carolina, United States, 27157 United States, Ohio Cleveland Clinic Cleveland, Ohio, United States, 44195 United States, Oregon Bend Memorial Clinic Bend, Oregon, United States, 97701 Oregon Health and Science University Knight Cancer Institute Portland, Oregon, United States, 97239 United States, Tennessee Vanderbilt University Medical Center, Department of Urology Surgery Nashville, Tennessee, United States, 37232 United States, Texas The Methodist Hospital Houston, Texas, United States, 77030 The University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT01143259 | - | - | Completed | - | - |
NCT01143259 | Ileus | Not Applicable | Completed | - | United States, Utah ... more >> American Fork Hospital American Fork, Utah, United States, 84003 Valley View Hospital Cedar City, Utah, United States, 84721 Logan Regional Hospital Logan, Utah, United States, 84341 Intermoutain Medical Center Murray, Utah, United States, 84157 McKay-Dee Hospital Ogden, Utah, United States, 84403 Utah Valley Provo, Utah, United States, 84604 LDS Hospital Salt Lake City, Utah, United States, 84103 Alta View Hospital Sandy, Utah, United States, 84094 Dixie Regional St. George, Utah, United States, 84790 Collapse << |
NCT00708201 | - | - | Completed | - | - |
NCT01150760 | - | - | Completed | - | United States, North Carolina ... more >> Premier database Charlotte, North Carolina, United States, 28208 Collapse << |
NCT01150760 | - | - | Completed | - | - |
NCT02742181 | Colorectal Surgery ... more >> Ileus Collapse << | Phase 3 | Unknown | April 2018 | United States, Ohio ... more >> University Hospitals Case Medical Center Cleveland, Ohio, United States, 44106 Collapse << |
NCT02218190 | Ileus Spinal ... more >>Fusion Collapse << | Not Applicable | Active, not recruiting | December 2018 | United States, Missouri ... more >> Barnes Jewish Hospital / Washington University in St. Louis School of Medicine Saint Louis, Missouri, United States, 63108 Collapse << |
NCT03352414 | Ileus | Phase 2 | Recruiting | March 2021 | United States, California ... more >> UCSD Moores Cancer Center Recruiting La Jolla, California, United States, 92093-0987 Contact: Joel M Baumgartner, MD, MAS 858-246-0581 j1baumgartner@ucsd.edu Collapse << |
NCT03068975 | Post Operative Ileus | Phase 4 | Not yet recruiting | April 2019 | - |
NCT03216525 | Bladder Cancer | Phase 3 | Not yet recruiting | April 2020 | - |
NCT02789111 | Constipation | Phase 4 | Recruiting | December 1, 2018 | United States, Virginia ... more >> University of Virginia Recruiting Charlottesville, Virginia, United States, 22908 Contact: Marcia E Birk, RN 434-924-2283 meb2w@virginia.edu Contact: Bhiken Naik, MBBCh 434-924-2283 bin4n@virginia.edu Principal Investigator: Bhiken Naik, MBBCh Collapse << |
靶点 | Description | IC50 |
---|---|---|
Opioid Receptor μ | IC50:1.7nM |
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