|N-乙基-3-苯基-N-(3-苯基丙基)丙烷-1-胺柠檬酸盐|CsnPharm

CAS No.: 5560-59-8

Alverine citrate/阿尔维林柠檬酸盐 Catalog No. CSN19442

Synonyms: NSC 35459;Alverine (citrate);Alverine

Alverine Citrate is a 5-HT1A receptor antagonist with IC50 value of 101 nM.

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实验方案

技术信息

生物活性

描述Alverine citrate, as a selective 5-HT1A receptor subtype antagonist, inhibits the rectal hypersensitivity induced by serotonin, a mediator involved in IBS(Irritable bowel syndrome) hyperalgesia^[3]. Alverine citrate is thought of as a smooth muscle relaxant, and is currently used as an antispasmodic in irritable bowel syndrome and dysmenorrhoea. Alverine (10 μM) increased the frequency and amplitude of spontaneous action potentials, transient increases in [Ca2+]i and associated contractions. Alverine suppressed contractions produced by high K (40 mM) or ACh (10 μM), without affecting electrical responses and with little suppression of increases in [Ca2+] ^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03549143	-	-	Recruiting	April 2019	Russian Federation ... more >> SM-Clinic LLC Recruiting Saint Petersburg, Russian Federation Contact: Ilchishina Alekseevna Collapse <<
NCT01404923	Irritable Bowel Syndrome	Phase 4	Completed	-	-
NCT01404923	-	-	Completed	-	-

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参考文献

[1] Wittmann T, Paradowski L, et al. Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome--a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2010 Mar;31(6):615-24.
[2] Coelho AM, Jacob L, et al. Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol. 2001 Oct;53(10):1419-26.
[3] Ducrotte P, Grimaud JC, Dapoigny M, Personnic S, O'Mahony V, Andro-Delestrain MC. On-demand treatment with alverine citrate/simeticone compared with standard treatments for irritable bowel syndrome: results of a randomised pragmatic study. Int J Clin Pract. 2014 Feb;68(2):245-54. doi: 10.1111/ijcp.12333. Epub 2013 Oct 21. PMID: 24147869; PMCID: PMC4282257.
[4] Hayase M, Hashitani H, Suzuki H, Kohri K, Brading AF. Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol. 2007 Dec;152(8):1228-38. doi: 10.1038/sj.bjp.0707496. Epub 2007 Oct 15. PMID: 17934514; PMCID: PMC2190002.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1117 mL
- 10.5584 mL
- 21.1167 mL
- 5 mM
- 0.4223 mL
- 2.1117 mL
- 4.2233 mL
- 10 mM
- 0.2112 mL
- 1.0558 mL
- 2.1117 mL

技术信息

CAS号

5560-59-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H35NO7

运输

蓝冰

分子量

473.56

别名

NSC 35459;Alverine (citrate);Alverine;Alverine Citrate;Phenopropamine;Phenpropamine;Profenil;Dipropyline;Spasmaverine;Sestron;Dipropylin

溶解度

DMSO	80.0 mg/mL (168.9 mM)
Water	12.0 mg/mL (25.3 mM) warming

动物实验配方

0.5% CMC-Na

30 mg/mL

suspension

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03549143	-	-	Recruiting	April 2019	Russian Federation ... more >> SM-Clinic LLC Recruiting Saint Petersburg, Russian Federation Contact: Ilchishina Alekseevna Collapse <<
NCT01404923	Irritable Bowel Syndrome	Phase 4	Completed	-	-
NCT01404923	-	-	Completed	-	-
NCT00934973	Irritable Bowel Syndrome	Phase 4	Completed	-	United Kingdom ... more >> University of Southampton Southampton, Hampshire, United Kingdom, SO17 1JB Collapse <<
NCT01678781	-	-	Completed	-	China ... more >> Site reference ID/Investigator# 94519 Beijing, China, 100034 Site reference ID/Investigator# 95475 Guangzhou City, China, 510515 Site reference ID/Investigator# 94521 Guangzhou, China, 510080 Site reference ID/Investigator # 94518 Shanghai, China, 200127 Site reference ID/Investigator # 94517 Shanghai, China, 200433 Site reference ID/Investigator # 94516 Shanghai, China Site reference ID/Investigator # 94515 Wuhan, China, 430022 Egypt Site Reference ID/Investigator# 95908 Alexandria, Egypt Site reference ID/Investigator# 95900 Cairo, Egypt Site reference ID/Investigator# 95901 El Sharkya, Egypt Site reference ID/Investigator# 95902 Giza, Egypt Site reference ID/Investigator# 95903 Giza, Egypt Site Reference ID/Investigator# 95906 Port Said, Egypt Mexico Site reference ID/Investigaot# 94525 Guadalajara, Mexico, 49000 Site refernce ID/Investigator# 94527 Mexico City, Mexico, 54055 Site reference ID/Investigator# 94523 Tampico, Mexico, 89190 Poland Site reference ID/Investigator# 85314 Bialystok, Poland, 15-270 Site Reference ID/Investigator# 85297 Bialystok, Poland, 15-351 Site Reference ID/Investigator# 85298 Bydgoszcz, Poland, 85-079 Site Reference ID/Investigator# 85293 Katowice, Poland, 40-031 Site Reference ID/Investigator# 85296 Lodz, Poland, 91-473 Site reference ID/Investigator# 85313 Olsztyn, Poland, 10-501 Site Reference ID/Investigator# 85295 Poznan, Poland, 60-193 Site Reference ID/Investigator# 85294 Poznan, Poland, 60-539 Collapse <<
NCT02260154	-	-	Completed	-	Russian Federation ... more >> Research Facility ID ORG-001035 Chita, Russian Federation, 672090 State Budget Institution " Irkutsk State Medical Academy of postgraduate education" Irkutsk, Russian Federation, 664049 Research Facility ID ORG-001038 Izhevsk, Russian Federation, 426034 Research Facility ID ORG-001033 Kazan, Russian Federation, 420029 Non-governmental Healthcare Institution "Road Clinical Hospital on the station Khabarovsk-1 OSS "Russian Railways" Khabarovsk, Russian Federation, 680022 Research Facility ID ORG-001034 Krasnoyarsk, Russian Federation, 660020 Research facility ID ORG-001039 Moscow, Russian Federation, 111123 Federal State Budget Institution "Outpatient hospital №1" Administration of the President of the Russian Federation Moscow, Russian Federation, 119002 State Budget Institution "Pirogov Russian National Research Medical University", on the base of State Budget Institution of Health Care of Moscow "City Clinical Hospital №31" Moscow, Russian Federation, 119415 State Budget Institution "Russian Medical Academy of Postgraduate Studies Moscow, Russian Federation, 123836 State Budget Institution of Health Care of Moscow region " MF Vladimirsky Moscow Region Scientific Research Clinical University" Moscow, Russian Federation, 129110 Research Facility ID ORG-001024 Moscow, Russian Federation, 129128 State Budget Institution "Nizhny Novgorod Regional Clinical Hospital n.a. Semashko" Nizhny Novgorod, Russian Federation, 603126 State Budget Institution "Novosibirsk State Medical University" Novosibirsk, Russian Federation Research Facility ID ORG-000903 Omsk, Russian Federation, 644043 Federal State Budget Institution Hospital of the Pushchino Scientific Center of the Russian Academy of Sciences Pushino, Russian Federation Research Facility ID ORG-001036 Rostov-on-Don, Russian Federation, 344022 Federal State Budget Institution All-Russian Center of Emergency and Radiation Medicine of EMERCOM of Russia Saint Petersburg, Russian Federation, 194044 State Budget Institution "North-Western State Medical University named after I.I. Mechnikov", on the base of State Budget Institution "Sity Clinical Hospital #26" Saint Petersburg, Russian Federation, 196247 Research Facility ID ORG-001037 Saransk, Russian Federation, 430005 City Clinical Hospital #40 Yekaterinburg, Russian Federation, , 620102 Collapse <<
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NCT00542295	Irritable Bowel Syndrome	Phase 4	Completed	-	Hungary ... more >> Budapest, Hungary, 1083 Budapest, Hungary, 1106 Budapest, Hungary, 1125 Budapest, Hungary, 1204 Debrecen, Hungary, 4032 Gyor, Hungary, 9024 Gyula, Hungary, 5700 Miskolc, Hungary, 3501 Miskolc, Hungary, 3529 Siofolk, Hungary, 8600 Szeged, Hungary, 6720 Székesfehérvár, Hungary, 8000 Poland Bydgoszcz, Poland, 85-168 Katowice, Poland, 40-752 Olawa, Poland, 55-200 Szczecin, Poland, 71-252 Wroclaw, Poland, 50-556 Wroclaw, Poland, 51-149 Collapse <<

Alverine citrate/阿尔维林柠檬酸盐 Catalog No. CSN19442

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