生物活性

• 描述Altretamine hydrochloride is an alkylating agent proposed as an antineoplastic.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00004218	Leukemia	Phase 3	Completed	-	-
  NCT00041210	Lymphoma	Phase 3	Unknown	-	United Kingdom ... more >> Basildon University Hospital Basildon, England, United Kingdom, SS16 5NL Royal United Hospital Bath, England, United Kingdom, BA1 3NG Kent and Canterbury Hospital Canterbury, England, United Kingdom, CT1 3NG Saint Richards Hospital Chichester, England, United Kingdom, P019 4SE Walsgrave Hospital Coventry, England, United Kingdom, CV2 2DX Doncaster Royal Infirmary Doncaster, England, United Kingdom, DN2 5LT Russells Hall Hospital Dudley, England, United Kingdom, DY1 2HQ Royal Devon and Exeter Hospital Exeter, England, United Kingdom, EX2 5DW Hemel Hempstead General Hemel Hempstead, England, United Kingdom, HP2 4AD Hull Royal Infirmary Hull, England, United Kingdom, HU3 2KZ King George Hospital Ilford, Essex, England, United Kingdom, IG3 8YB Lincoln County Hospital Lincoln, England, United Kingdom, LN2 5QY Royal Liverpool University Hospital Liverpool, England, United Kingdom, L7 8XP Aintree University Hospital Liverpool, England, United Kingdom, L9 7AL Saint Bartholomew's Hospital London, England, United Kingdom, EC1A 7BE St. George's Hospital London, England, United Kingdom, SW17 ORE University College Hospital - London London, England, United Kingdom, WC1E 6AU James Paget Hospital Norfolk, England, United Kingdom, NR31 6LA Mount Vernon Cancer Centre at Mount Vernon Hospital Northwood, England, United Kingdom, HA6 2RN Nottingham City Hospital NHS Trust Nottingham, England, United Kingdom, NG5 1PB Derriford Hospital Plymouth, England, United Kingdom, PL6 8DH Portsmouth Oncology Centre at Saint Mary's Hospital Portsmouth Hants, England, United Kingdom, PO3 6AD Oldchurch Hospital Romford, England, United Kingdom, RM7 OBE Cancer Research Centre at Weston Park Hospital Sheffield, England, United Kingdom, S1O 2SJ Southampton General Hospital Southampton, England, United Kingdom, SO16 6YD Staffordshire General Hospital Stafford, England, United Kingdom, ST16 3SA Royal Marsden - Surrey Sutton, England, United Kingdom, SM2 5PT Torbay Hospital Torquay, England, United Kingdom, TQ2 7AA City Hospital - Birmingham West Bromwich, England, United Kingdom, B71 4HJ New Cross Hospital Wolverhampton, England, United Kingdom, WV10 0QP Worthing Hospital Worthing, England, United Kingdom, BN11 2DH Cancer Care Centre at York Hospital York, England, United Kingdom, Y031 8HE Craigavon Area Hospital Craigavon, Northern Ireland, United Kingdom, BT63 5QQ Monklands General Hospital Airdrie, Scotland, United Kingdom, ML6 0JF Pinderfields General Hospital Wakefield, Scotland, United Kingdom, WF1 4DG Velindre Cancer Center at Velindre Hospital Cardiff, Wales, United Kingdom, CF14 2TL South West Wales Cancer Institute Swansea, Wales, United Kingdom, SA2 8QA Collapse <<
  NCT02495896	Head and Neck Squamous Cell Ca... more >>rcinoma Metastatic Pancreatic Adenocarcinoma Non-Resectable Cholangiocarcinoma Pancreatic Adenocarcinoma Recurrent Gallbladder Carcinoma Recurrent Non-Small Cell Lung Carcinoma Stage III Pancreatic Cancer Stage IIIA Gallbladder Cancer Stage IIIA Non-Small Cell Lung Cancer Stage IIIB Gallbladder Cancer Stage IIIB Non-Small Cell Lung Cancer Stage IV Gallbladder Cancer Stage IV Non-Small Cell Lung Cancer Stage IV Pancreatic Cancer Unresectable Gallbladder Carcinoma Unresectable Pancreatic Cancer Collapse <<	Phase 1	Recruiting	December 3, 2020	United States, California ... more >> USC / Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Anthony El-Khoueiry    323-865-3967    elkhouei@usc.edu    Principal Investigator: Anthony El-Khoueiry, MD          Hoag Memorial Hospital Presbyterian Recruiting Newport Beach, California, United States, 92663 Contact: Alicia Bogardus, MA    949-764-6755    Alicia.bogardus@hoag.org    Contact: Cristina De Leon, RN    949-764-5543    Cristina.deleon@hoag.org    Sub-Investigator: Diana Hanna, MD Collapse <<

• 参考文献

• [1] Chan JK, Loizzi V, et al. Oral altretamine used as salvage therapy in recurrent ovarian cancer. Gynecol Oncol. 2004 Jan;92(1):368-71.

  [2] Malik IA. Altretamine is an effective palliative therapy of patients with recurrent epithelial ovarian cancer. Jpn J Clin Oncol. 2001 Feb;31(2):69-73.