CAS No.: 1445379-92-9
ALS-8112 Catalog No. CSN17867
Synonyms: ALS-8176 Active Form;ALS-008112
ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Jordan PC, Stevens SK, et al. Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase. ACS Chem Biol. 2017 Jan 20;12(1):83-91.
- [2] Wang G, Deval J, et al. Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J Med Chem. 2015 Feb 26;58(4):1862-78.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1445379-92-9 | 储存条件 |
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| 分子式 | C10H13ClFN3O4 | 运输 | 蓝冰 | |
| 分子量 | 293.68 | 别名 | ALS-8176 Active Form;ALS-008112 |
