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CAS No.: 19885-10-0

Alisol A/泽泻醇A Catalog No. CSN13556

Synonyms: 泽泻醇 A

Alisol A, a natural product isolated and purified from the tubers of Alisma plantago-aquatica Linn., presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells) and enhances LC3II expression, indicates autophagy is occured, suggests that alisol A may be an autophagic inducer.

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生物活性

描述Alisol A is a bioactive triterpenoid isolated from the Rhizoma Alismatis. Alisol A inhibited the proliferation, migration, and invasion of NPC (nasopharyngeal carcinoma) cells by inhibiting the Hippo signaling pathway. In addition, Alisol A promoted the phosphorylation of YAP and suppressed the expression of YAP in NPC cells^[3]. Alisol A remarkably decreased lipid levels, alleviated glucose metabolism disorders and insulin resistance in high-fat-diet-induced obese mice. Alisol A reduced hepatic steatosis and improved liver function in the obese mice model^[4]. Alisol A can effectively inhibit the formation of arterial plaques and blocked the progression of AS in ApoE-/- mice fed with high-fat diet and significantly reduced the expression of inflammatory cytokins in aorta, including ICAM-1, IL-6, and MMP-9. Alisol A activated the AMPK/SIRT1 signaling pathway and NF-κB inhibitor IκBα in HepG2 cells^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0378 mL
- 10.1892 mL
- 20.3784 mL
- 5 mM
- 0.4076 mL
- 2.0378 mL
- 4.0757 mL
- 10 mM
- 0.2038 mL
- 1.0189 mL
- 2.0378 mL

技术信息

CAS号	19885-10-0	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C30H50O5	运输	蓝冰
分子量	490.72	别名	泽泻醇 A

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