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CAS No.: 54029-12-8

Albendazole Sulfoxide/阿苯达唑亚砜 Catalog No. CSN11486

Synonyms: Ricobendazole;Albendazole oxide;RS-8852

Albendazole Oxide can selectively inhibit beta-tubulin polymerization, used as an anthelmintic medicine.

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描述Albendazole oxide is a derivative of albendazole that inhibits the polymerization of tubulin into microtubules. It shows high inhibitory activity against E. intestinalis in vitro with an IC₅₀ value of 3ng/mL, which is 1.7-fold more inhibitory than albendazole^[3]. Albendazole oxide effectively inhibited the growth of Encephalitozoon hellem with IC₉₀ of <10^-4μg/mL. The IC₉₀ values of albendazole oxide against Encephalitozoon cuniculi and Encephalitozoon intestinalis were 6×10^-3 and 3.8×10^-2μg/mL, respectively^[4]. In rat hepatic microsomes, albendazole oxide reduces the activity of ethoxyresorufin O-deethylase (EROD) with an IC50 of 5µM^[5].
作用机制Albendazole oxide is a sulfoxide metabolite of albendazole that inhibits tubulin polymerization^[3].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5545 mL
- 17.7727 mL
- 35.5453 mL
- 5 mM
- 0.7109 mL
- 3.5545 mL
- 7.1091 mL
- 10 mM
- 0.3555 mL
- 1.7773 mL
- 3.5545 mL

技术信息

CAS号

54029-12-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H15N3O3S

运输

蓝冰

分子量

281.33

别名

Ricobendazole;Albendazole oxide;RS-8852

溶解度

DMSO	11.0 mg/mL (39.1 mM)
Water	Insoluble
Ethanol	Insoluble

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Albendazole Sulfoxide/阿苯达唑亚砜 Catalog No. CSN11486

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