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CAS No.: 1355326-35-0
Synonyms: IDH-C35
AGI-5198 is a potent and selective inhibitor of IDH1 R132H and R132C mutants with IC50 values of 0.07 and 0.16 µM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants.
生物活性
实验方案
技术信息
CAS号 | 1355326-35-0 | 储存条件 |
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分子式 | C27H31FN4O2 | 运输 | 蓝冰 | |||||||||||
分子量 | 462.56 | 别名 | IDH-C35 | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human HT1080 cells | - | Function assay | 48 h | Inhibition of IDH1 R132C mutant overexpressed in human HT1080 cells assessed as inhibition of 2-hydroxyglutarate production after 48 hrs by LC/MS analysis, IC50=0.48 μM | 24900389 |
human U87 cells | - | Function assay | 48 h | Inhibition of IDH1 R132H mutant expressed in human U87 cells assessed as inhibition of 2-hydroxyglutarate production after 48 hrs by LC/MS analysis, IC50=0.07 μM | 24900389 |
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