CAS No.: 1227678-26-3
Agerafenib HCl Catalog No. CSN17126
Synonyms: CEP-32496 hydrochloride;RXDX-105 hydrochloride;Agerafenib HCl
CEP-32496 HCl is a highly potent inhibitor of BRAF (V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively, displaying insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] James J, Ruggeri B, et al. CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity. Mol Cancer Ther. 2012 Apr;11(4):930-41.
- [2] Rowbottom MW, Faraoni R, et al. Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E. J Med Chem. 2012 Feb 9;55(3):1082-105.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1227678-26-3 | 储存条件 |
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| 分子式 | C24H23ClF3N5O5 | 运输 | 蓝冰 | |
| 分子量 | 553.92 | 别名 | CEP-32496 hydrochloride;RXDX-105 hydrochloride;Agerafenib HCl;RXDX 105 HCl |
