|1-(2,4-二氯苄基)-1H-吲唑-3-酰肼|CsnPharm

CAS No.: 252025-52-8

Adjudin Catalog No. CSN18157

Synonyms: AF-2364

Adjudin exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.

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技术信息

生物活性

描述Adjudin, a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway. Adjudin protects against cerebral ischemia reperfusion injury^[3]. Adjudin, a potential non-hormonal male contraceptive, exhibits additional function to reduce the production of proinflammatory mediators. Adjudin significantly inhibited LPS-induced IL-6 release and IL-6, IL-1β, TNF-α expression in BV2 microglial cells. Furthermore, Adjudin exhibited anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation^[4]. Adjudin attenuated the development of TBI-induced (traumatic brain injury) cerebral edema at least partly via anti-inflammatory effects and inhibition of the NF-κB pathway^[5]. Adjudin induced apoptosis in cancer cells through a Caspase-3-dependent pathway. Adjudin could trigger mitochondrial dysfunction in cancer cells, apparently affecting the mitochondrial mass, inducing the loss of mitochondrial membrane potential and reducing cellular ATP levels. Intraperitoneal administration of Adjudin to tumor-bearing athymic nude mice also significantly suppressed the lung and prostate tumor growth. When used in combination with cisplatin, Adjudin enhances the sensitivity to cisplatin-induced cancer cell cytotoxicity^[6]. Adjudin acts through activation of mitochondrion-located Sirt3 to safeguard hair cells of the cochlea from ototoxicant such as gentamycin. Adjudin could attenuate oxidative stress and cellular senescence^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9834 mL
- 14.9170 mL
- 29.8340 mL
- 5 mM
- 0.5967 mL
- 2.9834 mL
- 5.9668 mL
- 10 mM
- 0.2983 mL
- 1.4917 mL
- 2.9834 mL

技术信息

CAS号

252025-52-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H12Cl2N4O

运输

蓝冰

分子量

335.19

别名

AF-2364

溶解度

DMSO	66.0 mg/mL (196.9 mM)
Water	Insoluble
Ethanol	2.0 mg/mL (6.0 mM)

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