|((2R,3S,4R,5R)-5-(6-氨基-9H-嘌呤-9-基)-3,4-二羟基四氢呋喃-2-基)甲基磷酸二钠盐|CsnPharm

CAS No.: 4578-31-8

Adenosine 5′-monophosphate disodium salt/腺苷酸二钠盐 Catalog No. CSN23366

Synonyms: 5‘-腺嘌呤核苷酸二钠盐(5‘-AMP-NA2

Adenosine 5'-monophosphate disodium salt is an activator of AMPK and can be used as a substrate of AMP-thymidine kinase, AMP deaminase and 5′-nucleotidase.

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生物活性

描述Adenosine 5'-triphosphatedisodium salt hydrate is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation^[1]. ATP disodium salt hydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs. Furthermore, doxycycline addition markedly inhibited inﬂammasome activation and IL-1β production induced by a combination of P. gingivalis-LPS and ATP^[2]. ATP disodium salt hydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner. ATP disodium salt hydrate stimulates cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis. ATP disodium salt hydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo^[3].
参考文献

[1] Bours MJ, Swennen EL, Di Virgilio F, Cronstein BN, Dagnelie PC. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404
[2] Xu S, Zhou Q, Fan C, Zhao H, Wang Y, Qiu X, Yang K, Ji Q. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514
[3] Xiang Y, Wang X, Yan C, Gao Q, Li SA, Liu J, Zhou K, Guo X, Lee W, Zhang Y. Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome. PLoS One. 2013 May 22;8(5):e63759

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5563 mL
- 12.7817 mL
- 25.5634 mL
- 5 mM
- 0.5113 mL
- 2.5563 mL
- 5.1127 mL
- 10 mM
- 0.2556 mL
- 1.2782 mL
- 2.5563 mL

技术信息

CAS号	4578-31-8	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C10H12N5Na2O7P	运输	蓝冰
分子量	391.18	别名	5‘-腺嘌呤核苷酸二钠盐(5‘-AMP-NA2

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Adenosine 5′-monophosphate disodium salt/腺苷酸二钠盐 Catalog No. CSN23366

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