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CAS No.: 1675-66-7

Adelmidrol/阿地米屈 Catalog No. CSN17995

Synonyms: 阿地米屈

Adelmidrol is an ethanolamide derivative of azelaic acid with anti-inflammatory properties partly dependent on PPARγ, it also markedly reduce pro-inflammatory NF-κB pathway.

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400-920-2911

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技术信息

生物活性

描述Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol (10 mg/kg, o.s.) reduces significantly the degree and severity of the macroscopic and histologic signs of colon injury. Adelmidrol (10 mg/kg, o.s.) treatment significantly reduces the loss of body weight^[1]. Moreover, adelmidrol treatment was able to manage the significant incapacity of antioxidants and elevation of the oxidant burden, as shown by the MDA, SOD, and GSH levels and decreased nitric oxide production. It was also able to significantly modulate the JAK2/STAT3 and IκBα/NF-kB pathway^[2]. The combination of hyaluronic acid and adelmidrol improves the signs of OA (Osteoarthritis) induced by MIA (monosodium iodoacetate)^[3]. Topical treatment with adelmidrol might represent a new therapeutic tool in controlling the early and late allergic inflammatory skin responses in companion animals^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02583204	Breast Cancer ... more >> Nail Toxicity Collapse <<	Not Applicable	Unknown	April 2017	United Kingdom ... more >> Beatson Oncology Centre Glasgow, United Kingdom, G12 0YN Collapse <<
NCT01420510	Vaginitis	Phase 2 Phase 3	Unknown	December 2014	Italy ... more >> Gynecologic Oncology Unit Recruiting Varese, Italy, 21100 Contact: Fabio Ghezzi, MD +390332299309 fabio.ghezzi@uninsubria.it Principal Investigator: Fabio Ghezzi, MD Collapse <<

参考文献

[1] Cordaro M, Impellizzeri D, Gugliandolo E, Siracusa R, Crupi R, Esposito E, Cuzzocrea S. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease. Mol Pharmacol. 2016 Nov;90(5):549-561
[2] Fusco R, Cordaro M, Genovese T, Impellizzeri D, Siracusa R, Gugliandolo E, Peritore AF, D'Amico R, Crupi R, Cuzzocrea S, Di Paola R. Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary Fibrosis. Antioxidants (Basel). 2020 Jul 9;9(7):601
[3] Di Paola R, Fusco R, Impellizzeri D, Cordaro M, Britti D, Morittu VM, Evangelista M, Cuzzocrea S. Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. Arthritis Res Ther. 2016 Dec 12;18(1):291
[4] Cerrato S, Brazis P, Della Valle MF, Miolo A, Puigdemont A. Inhibitory effect of topical adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis. BMC Vet Res. 2012 Nov 26;8:230

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6448 mL
- 18.2242 mL
- 36.4485 mL
- 5 mM
- 0.7290 mL
- 3.6448 mL
- 7.2897 mL
- 10 mM
- 0.3645 mL
- 1.8224 mL
- 3.6448 mL

技术信息

CAS号

1675-66-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H26N2O4

运输

蓝冰

分子量

274.36

别名

阿地米屈

溶解度

DMSO	55.0 mg/mL (200.5 mM)
Water	54.0 mg/mL (196.8 mM)
Ethanol	27.0 mg/mL (98.4 mM)

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