CAS No.: 1361321-96-1
ACT-462206 Catalog No. CSN20430
ACT-462206 is a potent and brain-penetrant dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively), and it exhibits anxiolytic-like properties in vivo.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01954589 Safety Tolera... more >>bility Pharmacodynamics Pharmacokinetics Collapse << Phase 1 Completed - Netherlands ... more >> Centre for Human Drug Research Leiden, Netherlands, 2333 CL Collapse << - 参考文献
- [1] Boss C, Roch-Brisbare C, et al. Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 2014 Nov;9(11):2486-96.
- [2] Hoch M, van Gorsel H, et al. Entry-into-humans study with ACT-462206, a novel dual orexin receptor antagonist, comparing its pharmacodynamics with almorexant. J Clin Pharmacol. 2014 Sep;54(9):979-86.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1361321-96-1 | 储存条件 |
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| 分子式 | C20H24N2O4S | 运输 | 蓝冰 | |
| 分子量 | 388.48 | 别名 |
