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CAS No.: 480-44-4

Acacetin/金合欢素 Catalog No. CSN12350

Synonyms: 金合欢素;5,7-Dihydroxy-4'-methoxyflavone;4'-Methoxyapigenin

Acacetin shows inhibiton of the proliferation and induction apoptosis for cancer cells. It is a flavonoid purified from the bark of acacia farnesiana with anti-peroxidant, antiarthritic, and anti-inflammatory activities,

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技术信息

生物活性

描述Acacetin is an orally active flavonoid derived from Tephroseris kirilowii (Turcz.) Holub. Acacetin (10-200 μM; 24 hours) decreases cell viabilities in a dose-dependent manner. Acacetin has little effect on human normal glial cell line HEB and non-tumorigenic epithelial cell line MCF-10A. Acacetin (50-150 μM; 24 hours) causes G2/M cell cycle arrest and induces apoptosis and autophagy and leads to decreases in levels of PI3Kγ-p110, p-AKT, p-mTOR, p-p70S6K, and p-ULK in a dose-dependent manner^[3]. Acacetin significantly inhibited the release of NO and prostaglandin E(2) and the expression of inducible NO synthase and cyclooxygenase-2 in LPS-stimulated BV-2 cells. The compound also reduced proinflammatory cytokines, TNF-α and IL-1β, and inhibited the activation of NF-κB and p38 MAPK^[4]. The natural compound, acacetin, inhibits glutamate release from hippocampal synaptosomes by attenuating voltage-dependent Ca(2+) entry and effectively prevents KA-induced in vivo excitotoxicity^[5]. Acacetin (1.8-56.2 mg/kg/day; ip; single dose) decreases visceral and inflammatory nociception and prevented the formalin-induced oedema^[4]. Chronic acatetin (5, 15 or 45 mg/kg, p.o., once per day for three weeks) administration to mice engenders antidepressant-like efficacy on both behavior and stress axis responsivity, with serotonergic system that preferentially couples with 5-HT1A receptors being critically involved. In vitro, acacetin (1-100 nM) increased the Emax of 8-OH-DPAT^[6]. Intravenous infusion of acacetin prodrug (3, 6 and 12 mg/kg) terminated experimental AF without increasing ECG QTc interval in beagle dogs. The intravenous LD50 of acacetin prodrug was 721 mg/kg in mice^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5179 mL
- 17.5893 mL
- 35.1786 mL
- 5 mM
- 0.7036 mL
- 3.5179 mL
- 7.0357 mL
- 10 mM
- 0.3518 mL
- 1.7589 mL
- 3.5179 mL

技术信息

CAS号

480-44-4

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12O5

运输

蓝冰

分子量

284.26

别名

金合欢素;5,7-Dihydroxy-4'-methoxyflavone;4'-Methoxyapigenin;LY064233;NSC 76061

溶解度

DMSO	83.0 mg/mL (292.0 mM)
Water	insoluble

动物实验配方

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Acacetin/金合欢素 Catalog No. CSN12350

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