|1-(2,3-二(噻吩-2-基)喹喔啉-6-基)-3-(2-甲氧基乙基)脲|CsnPharm

CAS No.: 508186-14-9

Ac-CoA Synthase Inhibitor1/1-(2,3-二(噻吩-2-基)喹啉-6-基)-3-(2-甲氧基乙基)脲 Catalog No. CSN20801

Synonyms: Acetyl-CoA Synthase Inhibitor;ACCS2 Inhibitor;MDK6149

Ac-CoA Synthase Inhibitor is a reversible inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2) with IC50 of ~ 600 nM.

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技术信息

生物活性

描述Acetyl-CoA represents a central node of carbon metabolism that plays a key role in bioenergetics, cell proliferation and the regulation of gene expression. The nucleocytosolic acetyl-CoA synthetase enzyme, ACSS2, supplies a key source of acetyl-CoA for tumors by capturing acetate as a carbon source^[1]. ACSS2 inhibitor (quinoxaline) is a reversible inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2) with IC₅₀ of ~ 600 nM. This quinoxaline compound inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC₅₀ of 6.8 μM, and also inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC₅₀ of 5.5 μM^[1].
参考文献

[1] Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP. Acetate dependence of tumors. Cell. 2014 Dec 18;159(7):1591-602. doi: 10.1016/j.cell.2014.11.020. PMID: 25525877; PMCID: PMC4272450.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4360 mL
- 12.1799 mL
- 24.3598 mL
- 5 mM
- 0.4872 mL
- 2.4360 mL
- 4.8720 mL
- 10 mM
- 0.2436 mL
- 1.2180 mL
- 2.4360 mL

技术信息

CAS号

508186-14-9

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H18N4O2S2

运输

蓝冰

分子量

410.51

别名

Acetyl-CoA Synthase Inhibitor;ACCS2 Inhibitor;MDK6149;VY-3-249;ACSS2 inhibitor;Ac-CoA Synthase Inhibitor I

溶解度

DMSO	7.0 mg/mL (17.1 mM)
Water	Insoluble
Ethanol	2.0 mg/mL (4.9 mM)

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Ac-CoA Synthase Inhibitor1/1-(2,3-二(噻吩-2-基)喹啉-6-基)-3-(2-甲氧基乙基)脲 Catalog No. CSN20801

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