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CAS No.: 6147-11-1

α-mangostin/α-倒捻子素 Catalog No. CSN17082

Synonyms: α-倒捻子素;α-Mangostin;α-山竹素

alpha-Mangostin is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.

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纯度 & 质量文件批次:

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生物活性

实验方案

技术信息

生物活性

描述Alpha-mangostin, a natural xanthonoid, has antioxidant and anti-inflammatory properties. The IC₅₀ values of α-mangostin in MCF-7 cells were 3.57 μM in 24 h and 2.74 μM in 48 h. As for MDA-MB-231 cells, the IC₅₀ values were 3.35 μM in 24 h and 2.26 μM in 48 h. α-mangostin induced breast cancer cells apoptosis in a dose-dependent manner, reaching very high levels at 4 μM^[3]. In vitro, α-mangostin significantly reduced cell viability and induced apoptotic cell death. In addition, α-mangostin significantly disrupted the integrity of mitochondria measured by loss of MMP in a concentration-dependent manner^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01425047	-	-	Completed	-	United States, Ohio ... more >> The Ohio State University, Clinical Research Center Columbus, Ohio, United States, 43210 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4363 mL
- 12.1815 mL
- 24.3629 mL
- 5 mM
- 0.4873 mL
- 2.4363 mL
- 4.8726 mL
- 10 mM
- 0.2436 mL
- 1.2181 mL
- 2.4363 mL

技术信息

CAS号

6147-11-1

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H26O6

运输

蓝冰

分子量

410.46

别名

α-倒捻子素;α-Mangostin;α-山竹素

溶解度

DMSO	81.0 mg/mL (197.3 mM)
Water	Insoluble
Ethanol	82.0 mg/mL (199.8 mM)

动物实验配方

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