|((4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-10-(((2S,3R,4S,5S)-4,5-二羟基-3-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基）氧基)四氢-2H-吡喃-2-基)氧基)-9-(羟甲基)-2,2,6a,6b,9,12a-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-二十氢苉-4a-羧酸|CsnPharm

CAS No.: 27013-91-8

α-Hederin/α－常春藤皂苷 Catalog No. CSN10262

Synonyms: α-Hederin;Kalopanaxsaponin A;Koronaroside A

alpha-Hederin is a naturally occuring monodesmosidic triterpenoid saponin found in Hedera or Nigella species with anticancer potential activity.

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技术信息

生物活性

描述alpha-Hederin (α-hederin), a monodesmosidic triterpenoid saponin, exhibited promising antitumor potential against a variety of human cancer cell lines. α-hederin significantly inhibited the proliferation of gastric cancer cells and arrested the cell cycle in G1 phase in vitro. α-hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway^[3]. α-Hederin could inhibit the proliferation and induce apoptosis of ESCC (esophageal squamous cell carcinoma) via dissipation of the MMP (mitochondrial membrane potential) with simultaneous ROS (reactive oxygen species) generation and activation of the mitochondrial pathway^[4]. α‑hederin triggered apoptosis through ROS‑activated mitochondrial signaling pathway and autophagic cell death through ROS dependent AMPK(AMP‑activated protein kinase)/mTOR (mechanistic target of rapamycin) signaling pathway activation in colorectal cancer cells^[5]. α-hederin suppressed IL-6-induced EMT (Epithelial-mesenchymal transition) associated with disruption of JAK2/STAT3 signaling in colon cancer cells^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3316 mL
- 6.6582 mL
- 13.3164 mL
- 5 mM
- 0.2663 mL
- 1.3316 mL
- 2.6633 mL
- 10 mM
- 0.1332 mL
- 0.6658 mL
- 1.3316 mL

技术信息

CAS号

27013-91-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C41H66O12

运输

蓝冰

分子量

750.96

别名

α-Hederin;Kalopanaxsaponin A;Koronaroside A;NSC 106553;α-常春藤皂苷

溶解度

DMSO	98.0 mg/mL (130.5 mM)
Water	Insoluble

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