|(8R,9S,13S,14S,17R)-13-甲基-7,8,9,11,12,13,14,15,16,17-十氢-6H-环戊二烯并[a]菲-3,17-二醇|CsnPharm

CAS No.: 57-91-0

α-Estradiol/17a-雌二醇 Catalog No. CSN17211

Synonyms: Alfatradiol;Epiestradiol;Epiestrol

α-Estradiol is an endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述α-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Inhibition of the Testosterone Metabolism in Rat Liver Slices by 17 alpha-Estradiol^[3]. α-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression^[4]. α-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. α-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. α-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups^[5]. Seventeen α-estradiol (17α-E2) increase insulin sensitivity and extend lifespan in male mice, with less robust effects in female mice. 17α-E2 treatment decreased the number of primordial follicles in GHRKO (Growth hormone receptor knockout) mice. GHRKO mice displayed lesser primordial follicle activation as compared to wild type mice, but this phenotype was reversed by 17α-E2 administration, suggesting that ovarian aging is increased by 17α-E2 in long-living mice with extended reproductive longevity^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6713 mL
- 18.3566 mL
- 36.7131 mL
- 5 mM
- 0.7343 mL
- 3.6713 mL
- 7.3426 mL
- 10 mM
- 0.3671 mL
- 1.8357 mL
- 3.6713 mL

技术信息

CAS号

57-91-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H24O2

运输

蓝冰

分子量

272.38

别名

Alfatradiol;Epiestradiol;Epiestrol;17α-Estradiol;17alpha-Estradiol;alpha-Estradiol;α-Estradiol;17-epi Estradiol;17α-Oestradiol;NSC-20293;Avicis;Avixis;Ell-Cranell Alpha;Pantostin;α-雌二醇;17α-雌二醇

溶解度

DMSO	107.5 mg/mL (394.7 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

α-Estradiol/17a-雌二醇 Catalog No. CSN17211

靶点选择性

请登录您的专属账户

确认信息