|N-(3-氨基-3-氧代丙-1-烯-2-基)-2-((11S,14Z,21S,23S,29S)-14-亚乙基-3,23-二羟基-11-((1R)-(1-羟乙基))-31-甲基-9,12,19,24,33,43-六氧代-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-十六氢-21,36-([2,4]-endo-thiazolomethanimino)-5,8:15,18:37,40-三(azeno)-30,32-epimino苯并[h1]吡啶并[3,2-v][1]氧杂[10,20,26,30]四硫杂[6,13,16]三氮杂环三十六烷-2-基)噻唑-4-甲酰胺|CsnPharm

CAS No.: 56377-79-8

那西肽 Catalog No. CSN27363

Synonyms: 那西肽;Multhiomycin;RP 9671

Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth.

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技术信息

生物活性

描述Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth. Nosiheptide was also highly active against Enterococcus spp. and the contemporary hypervirulent BI/NAP1/027 strain of Clostridium difficile but was inactive against most Gram-negative strains tested. Nosiheptide (20 mg/kg; intraperitoneal injection; injected at 1 and 8 h post-infection; female CD1 mice) provids significant protection against mortality. Ten out of 10 of the Nosiheptide-treated mice remains alive on day 3, while 6/10 of the controls died on day 1^[3]. Nosiheptide (NOS) is a member of bicyclic thiopeptides possessing a biologically important indolic acid (IA) moiety appended onto the family-characteristic core system^[4].
参考文献

[1] Haste NM, et al. Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2012 Dec;65(12):593-8.
[2] Yu Y, et al. Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol. 2009 Oct 16;4(10):855-64.
[3] Haste NM, Thienphrapa W, Tran DN, Loesgen S, Sun P, Nam SJ, Jensen PR, Fenical W, Sakoulas G, Nizet V, Hensler ME. Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2012 Dec;65(12):593-8
[4] Zhang E, Guo H, Chen D, Yang Q, Fan Y, Yin Y, Wang W, Chen D, Wang S, Liu W. Mutational biosynthesis to generate novel analogs of nosiheptide featuring a fluorinated indolic acid moiety. Org Biomol Chem. 2020 Jun 7;18(21):4051-4055

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.8181 mL
- 4.0905 mL
- 8.1809 mL
- 5 mM
- 0.1636 mL
- 0.8181 mL
- 1.6362 mL
- 10 mM
- 0.0818 mL
- 0.4090 mL
- 0.8181 mL

技术信息

CAS号

56377-79-8

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C51H43N13O12S6

运输

蓝冰

分子量

1222.36

别名

那西肽;Multhiomycin;RP 9671

溶解度

DMSO	120.0 mg/mL (98.2 mM) warming

动物实验配方

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