|(((2R,3S,4R,5R)-5-(6-氨基-9H-嘌呤-9-基)-3,4-二羟基四氢呋喃-2-基)甲氧基)(((((2R,3S,4S)-5-(7,8-二甲基-2,4-二氧代-2H,3H,4H,10H-苯并[g]蝶啶-10-基)-2,3,4-三羟基戊基)氧基)(羟基)磷酰基)氧基)膦酸二钠盐|CsnPharm

CAS No.: 84366-81-4

黄素腺嘌呤二核苷酸二钠 Catalog No. CSN26257

Synonyms: 黄素腺嘌呤二核苷酸二钠;FAD disodium salt;FAD-Na2

Flavin Adenine Dinucleotide Disodium is a redox cofactor (electron carrier) by flavoproteins including succinate dehydrogenase (complex), α-ketoglutarate dehydrogenase, apoptosis-inducing factor 2 (AIF-M2, AMID), folate/FAD-dependent tRNA methyltransferases, and N-hydroxylating flavoprotein monooxygenases.

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描述Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism. With FAD (2 mg/kg), the CPZ (chlorpromazine)-induced decrease in VFT (ventricular fibrillation threshold) was significantly cancelled (92.2 +/- 4.2% of the initial level). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine^[1]. Poly(FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry^[2]. FAD in aqueous solution exhibits a significantly shorter excited state lifetime than its analog, the flavin mononucleotide^[3].
参考文献

[1] Sugiyama S, Ozawa T. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Jpn Heart J. 1979 Sep;20(5):657-65
[2] Karyakin AA, Ivanova YN, Revunova KV, Karyakina EE. Electropolymerized flavin adenine dinucleotide as an advanced NADH transducer. Anal Chem. 2004 Apr 1;76(7):2004-9
[3] Kieninger M, Ventura ON, Kottke T. Calculation of the Geometries and Infrared Spectra of the Stacked Cofactor Flavin Adenine Dinucleotide (FAD) as the Prerequisite for Studies of Light-Triggered Proton and Electron Transfer. Biomolecules. 2020 Apr 9;10(4):573

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2055 mL
- 6.0276 mL
- 12.0553 mL
- 5 mM
- 0.2411 mL
- 1.2055 mL
- 2.4111 mL
- 10 mM
- 0.1206 mL
- 0.6028 mL
- 1.2055 mL

技术信息

CAS号	84366-81-4	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C27H31N9Na2O15P2	运输	蓝冰
分子量	829.51	别名	黄素腺嘌呤二核苷酸二钠;FAD disodium salt;FAD-Na2

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黄素腺嘌呤二核苷酸二钠 Catalog No. CSN26257

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