|(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(苯甲酰氧基)-4,9,11-三羟基-4a,8,13,13-四甲基-5-氧代-2a,3,4,4a,5,6,9,10,11,12,12a,12b-十二氢-1H-7,11-甲桥环癸烷并[3,4]苯并[1,2-b]氧杂环丁烯-6,12b-二基二乙酸酯|CsnPharm

CAS No.: 27548-93-2

巴卡亭 Ⅲ Catalog No. CSN19460

Synonyms: 巴卡亭 Ⅲ;巴卡亭III

Baccatin III is a precursor to the anti-cancer drug paclitaxel, it's a natural product isolated and purified from the barks of Taxus chinensis.

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400-920-2911

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技术信息

生物活性

描述Baccatin III is a precursor to the anti-cancer drug paclitaxel, it's a natural product isolated and purified from the barks of Taxus chinensis. Baccatin III, which is the precursor for the semisynthesis of paclitaxel, exerts anti-tumor immunomodulatory activity in very low doses (0.05-0.5mg/kg). Oral administration of baccatin III significantly reduced the growth of tumors induced by engrafting BALB/c mice with either 4 T1 mammary carcinoma or CT26 colon cancer cells. Baccatin III (0.5mg/kg) did not exert anti-tumor activity in athymic nude mice. Baccatin III decreased the accumulation of MDSCs (Myeloid-derived suppressor cells) in the spleens of the tumor-bearing mice^[3]. Baccatin III inhibited cell proliferation of a number of cancer cell lines with IC50 ranging from 2 to 5 μM for fungal baccatin III. It also induced apoptosis in JR4-Jurkat cells with a possible involvement of anti-apoptotic Bcl2 and loss in mitochondrial membrane potential, and was unaffected by inhibitors of caspase-9,-2 or -3 but was prevented in presence of caspase-10 inhibitor. DNA fragmentation was also observed in cells treated with baccatin III^[4].
参考文献

[1] Gallego A, Imseng N, et al. Development of a hazel cell culture-based paclitaxel and baccatin III production process on a benchtop scale. J Biotechnol. 2015 Feb 10;195:93-102.
[2] Li Y, Yang J, et al. Isolation and identification of a 10-deacetyl baccatin-III-producing endophyte from Taxus wallichiana. Appl Biochem Biotechnol. 2015 Feb;175(4):2224-31.
[3] Lee YH, Lee YR, Park CS, Im SA, Song S, Hong JT, Whang BY, Kim K, Lee CK. Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice. Int Immunopharmacol. 2014 Aug;21(2):487-93
[4] Chakravarthi BV, Sujay R, Kuriakose GC, Karande AA, Jayabaskaran C. Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani. Cancer Cell Int. 2013 Oct 23;13(1):105

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7047 mL
- 8.5233 mL
- 17.0466 mL
- 5 mM
- 0.3409 mL
- 1.7047 mL
- 3.4093 mL
- 10 mM
- 0.1705 mL
- 0.8523 mL
- 1.7047 mL

技术信息

CAS号

27548-93-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C31H38O11

运输

蓝冰

分子量

586.63

别名

巴卡亭 Ⅲ;巴卡亭III

溶解度

DMSO	98.0 mg/mL (167.1 mM)
Water	insoluble

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