|((2S,2aR,2a1S,3aR,4R,5aR)-4-羟基-2-甲基-2a-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)六氢-2H-1,5-二氧杂-2,4-甲桥环丁烷[cd]戊搭烯-2a1-基)甲基苯甲酸酯|CsnPharm

CAS No.: 23180-57-6

芍药苷 Catalog No. CSN19431

Synonyms: 芍药苷;Peoniflorin

Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.

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生物活性

描述Paeoniflorin (PF) is the principal bioactive component of Radix Paeoniae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's disease (PD) ^[3]. Paeoniflorin, a compound found in white peony that inhibited the production of testosterone and promoted the activity of aromatase, which converts testosterone into estrogen^[4]. Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid-binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus. Also, thermotolerance was induced by treatment with paeoniflorin but not glycyrrhizin. Paeoniflorin had no toxic effect at concentrations as high as 80 microg/ mL (166.4 microM) ^[5]. Paeoniflorin significantly decreased serum insulin and glucagon levels, improved insulin sensitivity and serum lipids profiles, and alleviated hepatic steatosis in fructose-fed rats^[6]. Paeoniflorin pretreatment exerted protective effects in rat intestinal I/R injury. Paeoniflorin pretreatment significantly activated LKB1/AMPK signaling pathway by reversing the decreased LKB1 and AMPK phosphorylation without affecting total LKB1 both in vivo and in vitro^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01553643	Intracranial Arterial Stenosis	Phase 4	Unknown	-	Taiwan ... more >> China Medical University Hospital Recruiting Taiching, Taiwan Contact: Chung Hsiang Liu, MD. Collapse <<
NCT03608917	Vitiligo	Not Applicable	Enrolling by invitation	July 31, 2019	China, Shaanxi ... more >> Xijing Hospital Xi'an, Shaanxi, China, 710032 Collapse <<
NCT02878863	Hepatitis, Autoimmune	Phase 3	Withdrawn	July 2017	China, Sichuan ... more >> West China Hospital Chengdu, Sichuan, China, 610041 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0813 mL
- 10.4067 mL
- 20.8133 mL
- 5 mM
- 0.4163 mL
- 2.0813 mL
- 4.1627 mL
- 10 mM
- 0.2081 mL
- 1.0407 mL
- 2.0813 mL

技术信息

CAS号

23180-57-6

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H28O11

运输

蓝冰

分子量

480.46

别名

芍药苷;Peoniflorin

溶解度

DMSO	95.0 mg/mL (197.7 mM)
Water	94.0 mg/mL (195.6 mM)
Ethanol	94.0 mg/mL (195.6 mM)

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