|(2S,2a'E,2a1'S,4'E,5S,6R,6'S,7'S,8'E,11'R,15'S,17a'R,20'R,20a'R)-6-((S)-仲丁基)-2a1',20'-二羟基-7'-(((2R,4S,5S,6S)-4-甲氧基-5-(((2S,4S,5S,6S)-4-甲氧基-6-甲基-5-(甲基氨基)四氢-2H-吡喃-2-基)氧基)-6-甲基四氢-2H-吡喃-2-基)氧基)-5,6',8',19'-四甲基-2a1',5,6,6',7',10',11',14',15',17a',20',20a'-十二氢-2'H,17'H-螺[吡喃-2,13'-[11,15]甲桥[1,5]二氧杂环octadecino并[9,8,7-cd]苯并呋喃]-17'-酮苯甲酸盐|CsnPharm

CAS No.: 155569-91-8

甲维盐 Catalog No. CSN17006

Synonyms: MK-244;甲胺基阿维菌素苯甲酸盐

Emamectin benzoate acts as an activator of chloride channel via binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels. It can disrupt nerve signals in arthropods.

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描述Emamectin Benzoate (EMB) is activating GABA transporters. The LD50 for EMB applied alone was 0.751 ng/larva. EMB showed a significant decrease in GABA content at LD10, LD25, and LD50 doses.^[3]. Moreover, in vivo, administration of EMB caused a marked induction of oxidative damage in liver tissue as demonstrated by an increased level of TBARS and reduced GSH (Glutathione) level. Toxicity caused by EMB also showed the formation of genotoxicity with an increase in DNA oxidation biomarker 8-OHdG (8-hydroxy-2'-deoxyguanosine) levels^[4]. The target organs of Emamectin benzoate poisoning include heart, liver, kidney, lung, brain and contact position (stomach). The toxicant storage depots are kidney and liver. There is emamectin benzoate postmortem redistribution in mice^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.9918 mL
- 4.9591 mL
- 9.9183 mL
- 5 mM
- 0.1984 mL
- 0.9918 mL
- 1.9837 mL
- 10 mM
- 0.0992 mL
- 0.4959 mL
- 0.9918 mL

技术信息

CAS号

155569-91-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C56H81NO15

运输

蓝冰

分子量

1008.24

别名

MK-244;甲胺基阿维菌素苯甲酸盐

溶解度

DMSO	98.0 mg/mL (97.2 mM)
Water	Insoluble
Ethanol	100.0 mg/mL (99.2 mM)

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