|(2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-羟基-3-((2S,5R)-5-(2-羟基丙-2-基)-2-甲基四氢呋喃-2-基)-2a,5a,8,8-四甲基-9-(((2S,3R,4S,5R)-3,4,5-三羟基四氢-2H-吡喃-2-基)氧基)十六氢环戊烷并[a]环丙烷并[e]菲基-7-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 83207-58-3

(2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)hexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Catalog No. CSN16476

Synonyms: AS-A;AST-A;Astramembrannin I

Astragaloside A is one of the major active constituents of Astragalus membranaceus in traditional Chinese medicine and has been widely used to treat ischemic diseases.

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描述Astragaloside A (Astragaloside IV) (AS-IV) is one of the major active constituents of Astragalus membranaceus in traditional Chinese medicine and has been widely used to treat ischemic diseases. AS-IV has neuroprotective effects in cerebral ischemic models. Oral administration of AS-IV (10 and 20mg/kg, once per day, started 7days before surgery and continued for 7days after surgery) significantly attenuated memory impairment and neuroinflammation. AS-IV suppressed NLRP3 inflammasome activation by controlling ROS production. In addition, AS-IV markedly reduced overactivation of microglia and the overexpression of inflammatory cytokines in the hippocampus compared with the transient cerebral ischemia and reperfusion group^[3]. High doses of astragaloside IV (10, 20, 40 ng/ml) inhibited NSCLC cell growth, whereas low concentrations of astragaloside IV (1, 2.5, 5 ng/ml) had no obvious cytotoxicity on cell viability. Moreover, combined treatment with astragaloside IV significantly increased chemosensitivity to cisplatin in NSCLC (human non-small cell lung cancer) cells^[4]. High-dose astragaloside IV has a significant protective effect against D-GalN/LPS (D-galactosamine/lipopolysaccharide)-induced acute liver injury in mice, and its mechanisms may be associated with its effects against cell apoptosis and oxidative damage^[5]. AS-IV inhibited the viability and invasive potential of MDA-MB-231 breast cancer cells, suppressed the activation of the mitogen activated protein kinase (MAPK) family members ERK1/2 and JNK, and downregulated matrix metalloproteases (MMP)-2 and -9^[6]. ASV (Astragaloside IV) significantly inhibited TGF-β1(transforming growth factor-β1)/PI3K/Akt-induced FOXO3a (Forkhead box O3a) hyperphosphorylation and down-regulation to reverse EMT during the progression of fibrosis^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01553643	Intracranial Arterial Stenosis	Phase 4	Unknown	-	Taiwan ... more >> China Medical University Hospital Recruiting Taiching, Taiwan Contact: Chung Hsiang Liu, MD. Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2739 mL
- 6.3697 mL
- 12.7393 mL
- 5 mM
- 0.2548 mL
- 1.2739 mL
- 2.5479 mL
- 10 mM
- 0.1274 mL
- 0.6370 mL
- 1.2739 mL

技术信息

CAS号

83207-58-3

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C41H68O14

运输

蓝冰

分子量

784.97

别名

AS-A;AST-A;Astramembrannin I;Astramembrannin-IV;AS IV;黄芪甲苷

溶解度

DMSO	95.0 mg/mL (121.0 mM) warming
Water	Insoluble
Ethanol	Insoluble

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