|(1aS,1bS,2S,5aR,6S,6aS)-1a-(羟甲基)-2-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1a,1b,2,5a,6,6a-六氢环氧乙烷并[2',3':4]环戊烷并[1,2-c]吡喃-6-基 4-羟基-3-甲氧基苯甲酸酯|CsnPharm

CAS No.: 39012-20-9

胡黄连苷II Catalog No. CSN16331

Synonyms: 6-Vanilloylcatalpol;Vanilloyl catalpol;Ampicoside

Picroside II is a natural product isolated and purified from the roots of Picrorhiza scrophulariiflora, with anti-apoptotic and anti-inflammatory activities.

规格	价格	促销价格	库存	数量

400-920-2911

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生物活性

描述Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. The mortality in mice with sepsis was decreased by the administration of picroside II, and lung injury was alleviated simultaneously. Picroside II treatment enhanced bacterial clearance in septic mice. Further, picroside II treatment alleviated the inflammatory response in sepsis and enhanced immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways^[3]. Picroside II exerts protective effect on ANIT(alpha-naphthylisothiocyanate)-induced cholestasis possibly through FXR (farnesoid X receptor) activation that regulates the transporters and enzymes involved in bile acid homeostasis^[4]. Picroside II improved SAP (severe acute pancreatitis)-induced hepatocellular injury and antioxidant and anti-inflammatory properties by affecting JAK2/STAT3 phosphorylation signaling^[5]. Picroside II could protect the nervous system possibly through inhibiting the inflammatory response in the isoflurane-induced neuronal injury of rats^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9514 mL
- 9.7568 mL
- 19.5137 mL
- 5 mM
- 0.3903 mL
- 1.9514 mL
- 3.9027 mL
- 10 mM
- 0.1951 mL
- 0.9757 mL
- 1.9514 mL

技术信息

CAS号

39012-20-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H28O13

运输

蓝冰

分子量

512.46

别名

6-Vanilloylcatalpol;Vanilloyl catalpol;Ampicoside;胡黄连苷II;胡黄连苷Ⅱ

溶解度

DMSO	100.0 mg/mL (195.1 mM)

动物实验配方

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