|(1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-二羟基-6-(羟甲基)-5-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)甲基)-3,4,5-三羟基四氢-2H-吡喃-2-基 8,10,11-三羟基-9-(羟甲基)-1,2,6a,6b,9,12a-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-二十氢苉-4a-羧酸酯|CsnPharm

CAS No.: 34540-22-2

羟基积雪草苷 Catalog No. CSN16308

Synonyms: 羟基积雪草苷;Asiaticoside A

Madecassoside is a pentacyclic triterpene isolated from Centella asitica (L.), as an anti-inflammatory, anti-oxidative activities and anti-aging agent.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Madecassoside is a pentacyclic triterpene isolated from Centella asitica (L.), as an anti-inflammatory, anti-oxidative activities and anti-aging agent. ROS levels in cells treated with the MNTD (maximum non-toxic dose) of madecassoside were significantly reduced compared with cells treated with LPS alone^[3]. Madecassoside significantly inhibited the pro-inflammatory cytokine IL-1β, TLR2 and nuclear translocation of NF-κB in P. acnes stimulated THP-1 human monocytic cells. In addition, madecasssoside exhibited significant effects on enhancement of skin hydration through increasing the key moisturizing contributors of aquaporin-3, loricrin and involucrin in HaCaT keratinocytes as well as hyaluronan (HA) secretion in human dermal fibroblasts^[4]. MA (Madecassoside) represses osteoclastogenesis by blocking Ca2+ oscillations and the NF-κB and MAPK pathways^[5]. Madecassoside (30 mg/kg) treatment markedly ameliorated arthritis symptoms in rats, mainly evidenced by the reduction of paw swelling and arthritis index scores. Furthermore, unilateral cervical vagotomy significantly reduced the anti-arthritis efficacy of madecassoside, including the amelioration of clinical symptoms, as well as the inhibition of the production of pro-inflammatory cytokines except T lymphocytes-related cytokines^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02353273	Diabetic Foot	Phase 1	Completed	-	Taiwan ... more >> Clinical Research Division Taipei, Taiwan, 115 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.0255 mL
- 5.1276 mL
- 10.2551 mL
- 5 mM
- 0.2051 mL
- 1.0255 mL
- 2.0510 mL
- 10 mM
- 0.1026 mL
- 0.5128 mL
- 1.0255 mL

技术信息

CAS号

34540-22-2

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C48H78O20

运输

蓝冰

分子量

975.12

别名

羟基积雪草苷;Asiaticoside A

溶解度

DMSO	9.8 mg/mL (10.1 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

羟基积雪草苷 Catalog No. CSN16308

靶点选择性

请登录您的专属账户

确认信息