|(1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-二甲基乙基)六氢-4,7b-二羟基-8-甲基-9H-1,7a-(环氧甲烷)-1H,6aH-环戊基[c]呋喃[2-b]呋喃[3',2':3,4]环戊基[1,2-d]呋喃-5,9,12(4H)-三酮|CsnPharm

CAS No.: 15291-75-5

银杏内酯A Catalog No. CSN12568

Synonyms: BN-52020;银杏内酯A

Ginkgolide A is an antagonist of g-aminobutyric acid (GABA) with Ki of 14.5 μM and also can activate PAF. It is purified from the leaves of ginkgo biloba tree.

规格	价格	促销价格	库存	数量

400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 GABA Receptor

Ki:14.5μM
描述Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. Ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders^[3]. Ginkgolide-A (GA), a natural PXR ligand, attenuated BT in cirrhotic mice by abrogating inflammation along the gut-liver-axis, and by protecting small intestinal tight junctions (TJ)^[4]. GA could suppress the expression of pro-inflammatory mediators (cyclooxygenase-2 (COX-2) and nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β) in LPS-treated mouse peritoneal macrophages, mouse macrophage RAW264.7 cells, and differentiated human monocytes (dTHP-1) in vitro^[5]. GA is non-toxic at high concentrations in hepatocytes. Moreover, GA was found to inhibit cellular lipogenesis and lipid accumulation by causing mitochondrial oxidative stress. GA showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03772847	Intravenous Alteplase Thrombol... more >>ysis Neurological Improving Collapse <<	Phase 4	Recruiting	December 1, 2019	China, Zhejiang ... more >> Min Lou Recruiting Hangzhou, Zhejiang, China, 310000 Contact: Zexin Chen 13757118366 HREC2013@126.com Collapse <<
NCT02425436	Intrauterine Growth Restrictio... more >>n (IUGR) Collapse <<	Phase 2	Completed	-	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4486 mL
- 12.2429 mL
- 24.4858 mL
- 5 mM
- 0.4897 mL
- 2.4486 mL
- 4.8972 mL
- 10 mM
- 0.2449 mL
- 1.2243 mL
- 2.4486 mL

技术信息

CAS号

15291-75-5

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H24O9

运输

蓝冰

分子量

408.40

别名

BN-52020;银杏内酯A

溶解度

DMSO	80.0 mg/mL (195.9 mM)
Water	Insoluble
Ethanol	2.0 mg/mL (4.9 mM)

动物实验配方

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