|(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-二羟基-2-(噻吩-2-基)六氢吡喃并[3,2-d][1,3]二氧杂环己烯-6-基)氧基)-5-(4-羟基-3,5-二甲氧基苯基)-5,5a,8a,9-四氢呋喃并[3',4':6,7]萘并[2,3-d][1,3]二氧杂环戊烯-6(8H)-酮|CsnPharm

CAS No.: 29767-20-2

替尼泊苷 Catalog No. CSN12049

Synonyms: VM26;NSC 122819;HSDB-6546

Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA superhelicity and unlink double-stranded DNA segments during processes such as replication and transcription. In cells, type II topoisomerases are particularly useful for their ability to disentangle newly-replicated sister chromosomes^[3]. Teniposide is a topoisomerase II inhibitor. Teniposide (VM-26, 0.15-45 mg/L) inhibits the proliferation of Tca8113 cells in a dose-dependent manner, with an IC50 of 0.35 mg/L. Teniposide (5 mg/L) induces apoptosis of Tca8113 cells. Teniposide (5.0 mg/L) causes cell arrested at G2/M phase in Tca8113 cells^[4].Teniposide (0.5 mg/kg, i.p.) significantly increases micronucleated polychromatic erythrocyte (MNPCE) frequencies, which is directly related to bone marrow toxicity as significant suppression of bone marrow is noted. Teniposide (24 mg/kg, i.p.) markedly decreases the frequencies of BrdU-labelled sperm. Teniposide (12, 24 mg/kg, i.p.) also dramatically induces disomic sperm in the germ cell of male mice^[5]. Teniposide is active on primary cultured glioma cells from patients, when the level of miR-181b is high in the cells, with an IC50 of 1.3 ± 0.34 μg/mL. Cells treated with teniposide with low MDM2 have decreased viability compared with control cells, and the IC50 decreases from 5.86 ± 0.36 μg/mL to 2.90 ± 0.35 μg/mL upon MDM2 suppression. Teniposide also inhibits the viability of glioma cell with high level of miR-181b, through mediation of MDM2^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00198991	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Unknown	-	Germany ... more >> University of Frankfurt, Medical Dept. II Recruiting Frankfurt, Germany, 60590 Contact: Dieter Hoelzer, MD,PhD ++49(0)69 6301 5194 hoelzer@em.uni-frankfurt.de Contact: Nicola Goekbuget, MD ++49(0)69 6301 6365 goekbuget@em.uni-frankfurt.de Principal Investigator: Dieter Hoelzer, MD,PhD Sub-Investigator: Nicola Goekbuget, MD Collapse <<
NCT02086942	Multiple Myeloma	Phase 2	Recruiting	August 2017	China, Jiangsu ... more >> Jinling Hospital Recruiting Nanjing, Jiangsu, China, 210002 Contact: zhai yo ping, doctor 13951947646 ypzhai@medmail.com.cn Collapse <<
NCT00199004	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Completed	-	Germany ... more >> University Hospital of Frankfurt, Medical Dept. II Frankfurt, Germany, 60590 Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5229 mL
- 7.6144 mL
- 15.2287 mL
- 5 mM
- 0.3046 mL
- 1.5229 mL
- 3.0457 mL
- 10 mM
- 0.1523 mL
- 0.7614 mL
- 1.5229 mL

技术信息

CAS号

29767-20-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C32H32O13S

运输

蓝冰

分子量

656.65

别名

VM26;NSC 122819;HSDB-6546;CCRIS 2058. Brand name: Vumon;Vehem. Abbreviations: EPT;PTG;替尼泊苷

溶解度

DMSO	400.0 mg/mL (609.1 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	8 mg/mL	clear
PO	0.5% CMC-Na	45 mg/mL	suspension

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00198991	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Unknown	-	Germany ... more >> University of Frankfurt, Medical Dept. II Recruiting Frankfurt, Germany, 60590 Contact: Dieter Hoelzer, MD,PhD ++49(0)69 6301 5194 hoelzer@em.uni-frankfurt.de Contact: Nicola Goekbuget, MD ++49(0)69 6301 6365 goekbuget@em.uni-frankfurt.de Principal Investigator: Dieter Hoelzer, MD,PhD Sub-Investigator: Nicola Goekbuget, MD Collapse <<
NCT02086942	Multiple Myeloma	Phase 2	Recruiting	August 2017	China, Jiangsu ... more >> Jinling Hospital Recruiting Nanjing, Jiangsu, China, 210002 Contact: zhai yo ping, doctor 13951947646 ypzhai@medmail.com.cn Collapse <<
NCT00199004	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Completed	-	Germany ... more >> University Hospital of Frankfurt, Medical Dept. II Frankfurt, Germany, 60590 Collapse <<
NCT00199056	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Completed	-	Germany ... more >> University Hospital, Medical Dept. II Frankfurt, Germany, 60590 Collapse <<
NCT00199095	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Completed	-	Germany ... more >> University Hospital, Medical Dept. II Frankfurt, Germany, 60590 Collapse <<
NCT00002531	Leukemia	Phase 2	Unknown	-	Germany ... more >> Klinikum der J.W. Goethe Universitaet Frankfurt, Germany, D-60590 Collapse <<
NCT02645864	Esophageal Squamous Cell Carci... more >>noma Collapse <<	Phase 1	Recruiting	December 2017	China, Beijing ... more >> Peking University Cancer Hospital Recruiting Beijing, Beijing, China, 100142 Contact: Xiaodong Zhang 86-10-88196961 zxd0829@hotmail.com Principal Investigator: Xiaodong Zhang Collapse <<
NCT00187083	Acute Lymphoblastic Leukemia	Phase 3	Completed	-	United States, Tennessee ... more >> St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse <<
NCT00343369	Leukemia	Not Applicable	Unknown	-	Germany ... more >> Evangelisches Krankenhauus Bielfeld Recruiting Biefeld, Germany, 33617 Contact: N. Jorch, MD 49-52-177-278-050 Klinikum Bremen-Mitte Recruiting Bremen, Germany, D-28205 Contact: Arnulf Pekrun, MD, PhD 49-421-497-3656 arnulf.pekrun@klinikum-bremen-mitte.de Universitaetsklinikum Duesseldorf Recruiting Duesseldorf, Germany, D-40225 Contact: Contact Person 49-211-311-7990 Universitats - Kinderklinik Recruiting Greiswald, Germany, 17487 Contact: James F. Beck, MD 49-383-486-6325 beck@uni-greifswald.de University Medical Center Hamburg - Eppendorf Recruiting Hamburg, Germany, D-20246 Contact: Gritta Janka-Schaub 49-404-2803-2580 Kreskrankenhaus Kinderabteilung Recruiting Heide, Germany, 25746 Contact: Streitberger 49-481-785-911 Clinic for Bone Marrow Transplantation and Hematology and Oncology Recruiting Idar-Oberstein, Germany, D-55743 Contact: Wenzel Nuernberger, MD, PhD 49-6781-66-1582 wnuernberger@bmt-center-io.com Klinikum Krefeld GmbH Recruiting Krefeld, Germany, D-47805 Contact: P. Thomas 49-2151-322-375 Universitaets - Kinderklinik Recruiting Leipzig, Germany, D-04317 Contact: Dieter Koerholz, MD 49-341-9726-246 koerd@medizin.uni-leipzig.de Johannes Gutenberg University Recruiting Mainz, Germany, D-55101 Contact: P. Gutjahr, MD 49-6131-17-2112 Krankenhaus Neuwerk Klinik fuer Kinder und Jugendmedizin Recruiting Moenchengladbach, Germany, D-41066 Contact: Wolfgang Mueller, MD 49-2161-668-2481 Dr. von Haunersches Kinderspital der Universitaet Muenchen Recruiting Munich, Germany, D-80337 Contact: Arndt Borkhardt 49-89-5160-4498 Staedtisches Krankenhaus Muenchen - Harlaching Recruiting Munich, Germany, D-81545 Contact: Papucek 49-89-6210-2710 Klinik St. Hedwig-Kinderklinik Recruiting Regensburg, Germany, 93049 Contact: Ove Peters 49-941-369-5404 Dr. Horst-Schmidt-Kliniken Recruiting Wiesbaden, Germany, D-65199 Contact: Gerhard Beron, MD 49-611-43-2564 Helios Kliniken Wuppertal University Hospital Recruiting Wuppertal, Germany, D-42283 Contact: B. Dohrn, MD 49-202-896-3823 bdohrn@wuppertal.helios-klinikum.de Collapse <<
NCT00199069	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Completed	-	Germany ... more >> University Hospital, Medical Dept. II Frankfurt, Germany Collapse <<
NCT02788201	Urothelial Carcinoma ... more >> Bladder Cancer Urinary Bladder Neoplasms Collapse <<	Phase 2	Recruiting	July 1, 2020	United States, Maryland ... more >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office 888-624-1937 Collapse <<
NCT01290120	Burkitt Lymphoma ... more >> B-ALL Collapse <<	Phase 2	Completed	-	Italy ... more >> Divisione di Ematologia e TMO, Ospedale San Maurizio Bolzano, (bz), Italy Ematologia e centro TMO - Ospedale Armando Businco Cagliari, (ca), Italy S.C. Ematologia - Azienda Ospedaliera S. Croce e Carle Cuneo, (cn), Italy Onco-Ematologia - Ospedale Civile Noale, (ve), Italy Dipartimento di Ematologia e Medicina Trasfusionale - Azienda Osp. Nazionale Santi Antonio e Biagio e Cesare Arrigo Alessandria, AL, Italy USC Ematologia Ospedali Riuniti di Bergamo Bergamo, BG, Italy Divisione Ematologia Spedali Civili Brescia, BS, Italy, 25123 Ematologia - AOU Careggi Firenze, FI, Italy Ematologia e TMO - Ospedale San Raffaele Milano, MI, Italy Ematologia - TMO - Ospedale San Gerardo Monza, MI, Italy Ematologia Ospedale San Bortolo Vicenza, VI, Italy, 36100 USC Ematologia Ospedali Riuniti di Bergamo Bergamo, Italy, 24128 Collapse <<
NCT02290132	-	-	Unknown	July 2017	China, Shanghai ... more >> Shanghai First People's HOSPITAL Recruiting Shanghai, Shanghai, China, 200127 Contact: YANG JUN, master 13564880726 yangjuan74@hotmail.com Contact: wang chun, doctor 13386259777 wangchun2@medmail.com.cn Collapse <<
NCT00004231	Lymphoma	Phase 2	Completed	-	United States, Illinois ... more >> Robert H. Lurie Comprehensive Cancer Center at Northwestern University Chicago, Illinois, United States, 60611 Collapse <<
NCT01430013	T Cell Lymphoma	Phase 2	Unknown	December 2015	China, Tianjin ... more >> Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin, China, 300060 Collapse <<
NCT00853008	Acute Lymphoblastic Leukemia	Phase 4	Active, not recruiting	January 2019	Spain ... more >> Hospital General Alicante, Spain Hospital Germans Trias i Pujol Badalona, Spain Clínica Teknon Barcelona, Spain Hospital Clínic i Provincial Barcelona, Spain Hospital de Sant Pau Barcelona, Spain Hospital Duran y Reynals Barcelona, Spain Hospital Vall d'Hebrón Barcelona, Spain Hospital General Castellón, Spain Hospital San Pedro de Alcántara Cáceres, Spain Hospital Puerta del Mar Cádiz, Spain Hospital Josep Trueta Girona, Spain Hospital Universitario Guadalajara, Spain Hospital Juan Canalejo La Coruña, Spain Hospital Xeral Lugo, Spain Hospital 12 de Octubre Madrid, Spain Hospital Clínico Universitario Madrid, Spain Hospital de Fuenlabrada Madrid, Spain Hospital Ramón y Cajal Madrid, Spain Hospital Morales Messeguer Murcia, Spain Hospital Carlos Haya Málaga, Spain Hospital Virgen de la Victoria Málaga, Spain Hospital Central de Asturias Oviedo, Spain Hospital Son Llàtzer Palma de Mallorca, Spain Clínica Universitaria de Navarra Pamplona, Spain Hospital Parc Taulí Sabadell, Spain Hospital Clínico Universitario Salamanca, Spain Hospital Marqués de Valdecilla Santander, Spain Hospital Xeral Santiago, Spain Hospital Virgen del Rocio Sevilla, Spain Hospital Joan XXIII Tarragona, Spain Hospital Mútua de Terrassa Terrassa, Spain Hospital Clínico Universitario Valencia, Spain Hospital Dr Pesset Valencia, Spain Hospital General Valencia, Spain Hospital La Fe Valencia, Spain Hospital Clínico Valladolid, Spain Hospital Virgen de la Concha Zamora, Spain Hospital Lozano Blesa Zaragoza, Spain Collapse <<
NCT02028650	-	-	Completed	-	China, Beijing ... more >> Affiliated Hospital of Academy of Military Medical Sciences Beijing, Beijing, China, 100071 Collapse <<
NCT00696735	Follicular Lymphoma	Phase 3	Completed	-	France ... more >> Emmanuel GYAN Tours, France, 37000 Philippe COLOMBAT Tours, France, 37000 Collapse <<
NCT00184041	Acute Lymphoblastic Leukemia	Phase 2	Completed	-	United States, California ... more >> USC/Norris Comprehensive Cancer Center and Hospital Los Angeles, California, United States, 90032 Collapse <<
NCT01700946	Recurrent B-Cell Childhood Acu... more >>te Lymphoblastic Leukemia Recurrent Childhood B-Lymphoblastic Lymphoma Collapse <<	Phase 2	Recruiting	October 2021	United States, California ... more >> Rady Children's Hospital and Health Center Completed San Diego, California, United States, 92123 United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Sima Jeha, MD 866-278-5833 referralinfo@stjude.org Principal Investigator: Sima Jeha, MD United States, Texas Cook Children's Medical Center Recruiting Fort Worth, Texas, United States, 76104 Contact: Kenneth M. Heym, MD 682-885-4007 Principal Investigator: Kenneth M. Heym, MD Collapse <<
NCT00186875	Acute Lymphoblastic Leukemia ... more >> Lymphoma, Lymphoblastic Collapse <<	Phase 2	Completed	-	United States, California ... more >> Rady Children's Hospital and Health Center San Diego, California, United States, 92123 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse <<
NCT00186875	-	-	Completed	-	-
NCT01960192	Primary CNS Lymphoma (PCNSL)	Phase 4	Recruiting	June 2020	China, Henan ... more >> Oncology Department of The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450052 Contact: Mingzhi Zhang, Pro,Dr 13838565629 mingzhi_zhang@126.com Collapse <<
NCT00004916	Lymphoma	Phase 1 Phase 2	Completed	-	United States, Illinois ... more >> Robert H. Lurie Comprehensive Cancer Center, Northwestern University Chicago, Illinois, United States, 60611-3013 Collapse <<

替尼泊苷 Catalog No. CSN12049

靶点选择性

请登录您的专属账户

确认信息