|(2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基((4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5S,6R)-4,5-二羟基-6-(羟甲基)-3-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基）氧基)四氢-2H-吡喃-2-基)氧基-4,11b-二甲基-8-亚甲基十四氢-6a,9-甲基环庚[a]萘-4-羧酸酯|CsnPharm

CAS No.: 57817-89-7

甜菊糖 Catalog No. CSN11984

Synonyms: 甜菊苷;甜菊糖苷

Stevioside, a natural product isolated and purified from the leaves of Stevia rebaudiana, is a safe natural sweetener, has no allergic reactions, suited for both diabetics, and PKU patients, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet. Stevioside also exerts anti-inflammatory and anti-apoptotic properties by inhibiting the release of cytokines and the activation of TLR2 and proteins of the NF-κB and MAPK signaling pathways, as well as caspase-3 and Bax. Stevioside and steviol attenuate LPS-induced pro-inflammatory cytokine productions by affecting cytokine gene expression via IκBα/NF-κB signalling pathway.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Stevioside is obtained from leaves of Stevia rebaudiana. Stevioside is an important source of biochemically active substances with proven anti-diabetic effect. Stevioside solution prevented significant increase in glycaemia in oral glucose tolerance test (9.22 ± 1.13 to 9.85 ± 1.32 mmol/l, P < 0.05), and not in adrenaline test^[3]. Stevioside inhibited the mRNA and protein expression of TNF-α, IL-6 and IL-1β dose-dependently in S.aureus-stimulated MMECs. Stevioside suppressed the S.aureus-induced expression of TLR2 and proteins of the NF-κB and MAPK pathways as well as apoptosis^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02880124	Carbohydrate Ingestion ... more >> Fuel Selection Athletic Performance Collapse <<	Not Applicable	Recruiting	December 2017	Canada, Quebec ... more >> Centre d'éducation physique et sportive de l'Université de Montréal (CEPSUM) Recruiting Montréal, Quebec, Canada, H3C 3J7 Contact: Mélanie F Paradis, M.Sc. 514-571-4122 melanie.paradis@umontreal.ca Contact: Lorianne Lavoie, B.Sc. 514-466-3393 lorianne.lavoie@umontreal.ca Principal Investigator: Jonathan Tremblay, Ph.D. Collapse <<
NCT02634164	Hyperglycemia	Not Applicable	Completed	-	-
NCT03115385	Obesity, Abdominal ... more >> Adiposity Collapse <<	Not Applicable	Terminated(Funds ended.)	-	United States, California ... more >> University of Southern California Los Angeles, California, United States, 90033 Collapse <<

更多
参考文献

[1] Wang T, Song X, et al. Stevioside inhibits inflammation and apoptosis by regulating TLR2 and TLR2-related proteins in S. aureus-infected mouse mammary epithelial cells. Int Immunopharmacol. 2014 Sep;22(1):192-9.
[2] Boonkaewwan C, Burodom A. Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells. J Sci Food Agric. 2013 Dec;93(15):3820-5.
[3] Ilić V, Vukmirović S, Stilinović N, Čapo I, Arsenović M, Milijašević B. Insight into anti-diabetic effect of low dose of stevioside. Biomed Pharmacother. 2017 Jun;90:216-221. doi: 10.1016/j.biopha.2017.03.045. Epub 2017 Mar 28. PMID: 28363166.
[4] Wang T, Song X, Zhang Z, Guo M, Jiang H, Wang W, Cao Y, Zhu L, Zhang N. Stevioside inhibits inflammation and apoptosis by regulating TLR2 and TLR2-related proteins in S. aureus-infected mouse mammary epithelial cells. Int Immunopharmacol. 2014 Sep;22(1):192-9. doi: 10.1016/j.intimp.2014.06.015. Epub 2014 Jun 27. PMID: 24975657.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2424 mL
- 6.2122 mL
- 12.4244 mL
- 5 mM
- 0.2485 mL
- 1.2424 mL
- 2.4849 mL
- 10 mM
- 0.1242 mL
- 0.6212 mL
- 1.2424 mL

技术信息

CAS号	57817-89-7	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C38H60O18	运输	蓝冰
分子量	804.87	别名	甜菊苷;甜菊糖苷

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02880124	Carbohydrate Ingestion ... more >> Fuel Selection Athletic Performance Collapse <<	Not Applicable	Recruiting	December 2017	Canada, Quebec ... more >> Centre d'éducation physique et sportive de l'Université de Montréal (CEPSUM) Recruiting Montréal, Quebec, Canada, H3C 3J7 Contact: Mélanie F Paradis, M.Sc. 514-571-4122 melanie.paradis@umontreal.ca Contact: Lorianne Lavoie, B.Sc. 514-466-3393 lorianne.lavoie@umontreal.ca Principal Investigator: Jonathan Tremblay, Ph.D. Collapse <<
NCT02634164	Hyperglycemia	Not Applicable	Completed	-	-
NCT03115385	Obesity, Abdominal ... more >> Adiposity Collapse <<	Not Applicable	Terminated(Funds ended.)	-	United States, California ... more >> University of Southern California Los Angeles, California, United States, 90033 Collapse <<
NCT02411565	Ovarian Cancer	Not Applicable	Terminated(Drug manufacturing ... more >>issues) Collapse <<	-	United States, Florida ... more >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 Collapse <<
NCT02825823	Exercise Keto... more >>nes Dietary Supplements Collapse <<	Not Applicable	Completed	-	Canada, British Columbia ... more >> University of British Columbia, Okanagan. Kelowna, British Columbia, Canada, V1V 1V7 Collapse <<
NCT02677649	Fecal Microbiota	Not Applicable	Completed	-	United States, Massachusetts ... more >> Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University Boston, Massachusetts, United States, 02111 Collapse <<
NCT03486145	High Blood Pressure ... more >> Flow Mediated Dilation Collapse <<	Not Applicable	Completed	-	United States, Arizona ... more >> Arizona State University Phoenix, Arizona, United States, 85004 Collapse <<
NCT03510624	Type 2 Diabetes Mellitus	Phase 1	Not yet recruiting	June 1, 2019	-
NCT03667703	Congenital Heart Disease ... more >> Upper Gastrointestinal Bleeding Stress Ulcer Infection Collapse <<	Not Applicable	Not yet recruiting	June 30, 2021	United States, Massachusetts ... more >> Boston Children's Hospital Not yet recruiting Boston, Massachusetts, United States, 02115 Contact: Kimberly I Mills, MD 617-355-7866 kimberly.mills@cardio.chboston.org Contact: Ben D Albert, MD 617-355-7866 ben.albert@childrens.harvard.edu Collapse <<
NCT03680482	Diabetes Mellitus, Type 2	Not Applicable	Completed	-	-
NCT03724864	Dental Caries	Not Applicable	Completed	-	Italy ... more >> Pediatric dentistry dept Sassari, Italy Collapse <<
NCT02580110	Healthy Subjects	Not Applicable	Completed	-	Sweden ... more >> Food for Health Science Centre, Medicon Village, Lund University Lund, Sweden, , SE-223 81 LUND Collapse <<
NCT01757990	Dental Caries	Phase 2	Completed	-	-
NCT02800707	Impaired Glucose Tolerance	Not Applicable	Completed	-	United States, Minnesota ... more >> ECRC Minneapolis, Minnesota, United States, 55454 Collapse <<
NCT03708939	Glucose Intolerance ... more >> Glucose, Low Blood Glucose, High Blood Collapse <<	Not Applicable	Enrolling by invitation	January 1, 2021	Israel ... more >> Weizmann Institute of Science Reẖovot, Israel Collapse <<
NCT02146183	Glycogen Depletion	Not Applicable	Unknown	July 2015	Denmark ... more >> Aarhus University Hospital, Dept of Clinical medicine Recruiting Aarhus C, Denmark, 8000 Contact: Per B Jeppesen, Prof, PhD +45-28151877 per.bendix.jeppesen@ki.au.dk Principal Investigator: Per B Jeppesen, Prof, PhD Sub-Investigator: Søren Larvsen, Prof-Sport Collapse <<
NCT01115088	Obesity Type ... more >>2 Diabetes Collapse <<	Not Applicable	Completed	-	United States, Louisiana ... more >> Pennington Biomedical Research Center Baton Rouge, Louisiana, United States, 70808 Collapse <<
NCT02834715	Diabetes Mellitus	Not Applicable	Completed	-	Cameroon ... more >> National Obesity Centre Yaounde, Cameroon Collapse <<
NCT01488383	Hyperglycemia ... more >> Hypertension Collapse <<	Not Applicable	Withdrawn(not i)	September 2013	Spain ... more >> Basque Public Health Service-Osakidetza (Lakuabizkarra primary care center and Txagorritxu hospital) Vitoria-Gasteiz, Alava, Spain, 01009 Collapse <<
NCT03259685	Gut Microbiota ... more >> Metabolic Syndrome Collapse <<	Not Applicable	Recruiting	December 2020	Canada ... more >> Laval University Recruiting Québec, Canada, G1V0A6 Contact: Marie-Claude Vohl 418-656-2131 ext 4676 marie-claude.vohl@ulaval.ca Collapse <<

甜菊糖 Catalog No. CSN11984

靶点选择性

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