生物活性

• 描述Azithromycin (Dihydrate) is an azalide, a subclass of macrolide antibiotics. It prevents bacteria from growing by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome and thus inhibits translation of mRNA. Azithromycin is used to treat or prevent certain bacterial infections, most often those causing middle ear infections, strep throat, pneumonia, typhoid, bronchitis, and sinusitis^[3]. Azithromycin dose-dependently augmented viral-induced IFNβ (interferons, IFNs) expression in asthmatic, but not in healthy bronchial epithelial cells. Clinically relevant concentrations of azithromycin produce MDA5-dependent, anti-viral, IFN-inducing effects in bronchial epithelium distinctly from asthmatic donors^[4]. Azithromycin treatment induced a perturbation in the gut microbiota 14 days after randomization but did not have long-lasting effects on the gut microbiota composition^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00694694	Malaria	Phase 3	Completed	-	Tanzania ... more >> Teule Hospital Muheza, Tanga Region, Tanzania Collapse <<
  NCT01235546	Endometritis ... more >>Wound Infection Abscess Surgical Site Infection Collapse <<	Not Applicable	Completed	-	United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35233 United States, Louisiana Ochsner Clinic Foundation New Orleans, Louisiana, United States, 70121 United States, Mississippi University of Mississippi Medical Center Jackson, Mississippi, United States, 39216 United States, New York Columbia University New York, New York, United States, 10032 United States, North Carolina Mission Hospital Asheville, North Carolina, United States, 28801 University of North Carolina Chapel Hill, North Carolina, United States, 27599-7516 United States, Texas University of Texas Medical Branch Galveston, Texas, United States, 77555-0587 University of Texas Health Science Center at Houston Houston, Texas, United States, 77225 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 Collapse <<
  NCT02527005	Malaria Pregn... more >>ant HIV Collapse <<	Phase 1	Completed	-	Nigeria ... more >> University College Hospital, Ibadan, Oyo, Nigeria, 200001 Collapse <<

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• 参考文献

• [1] Menzel M, Akbarshahi H, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 May 9;8(19):31601-31611.

  [2] Vandooren J, Knoops S, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853.

  [3] Bakheit AH, Al-Hadiya BM, Abd-Elgalil AA. Azithromycin. Profiles Drug Subst Excip Relat Methodol. 2014;39:1‐40

  [4] Menzel M, Akbarshahi H, Tufvesson E, Persson C, Bjermer L, Uller L. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017;8(19):31601‐31611

  [5] Wei S, Mortensen MS, Stokholm J, et al. Short- and long-term impacts of azithromycin treatment on the gut microbiota in children: A double-blind, randomized, placebo-controlled trial. EBioMedicine. 2018;38:265‐272

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