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CAS No.: 1034895-42-5

9-ING-41 Catalog No. CSN27603

Synonyms: Elraglusib

9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

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技术信息

生物活性

描述Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, is a master regulator of neural progenitor homeostasis, integrating multiple proliferation, and differentiation signals, and thus has been focused on as a potential target in neuroblastoma. 9-ING-41, a potent and selective small-molecule GSK-3 inhibitor, is active in neuroblastoma. In cell viability assay, 9-ING-41 inhibited the growth of SK-N-DZ and SK-N-BE(2) neuroblastoma cells with GI₅₀s among 50–100 nM. 9-ING-41 (0.1–1 µM) inhibited GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells^[1]. Teretment with low doses of 9-ING-41 for 48 hours specifically induced lymphoma cell apoptosis without affecting normal lymphocytes^[2]. In vivo, 9-ING-41 (70 mg/kg) potentiated the effects of CPT-11 (5 mg/kg) in growth inhibition of neuroblastoma xenograft tumors^[1].
参考文献

[1] Ugolkov AV, et al. 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma. Anticancer Drugs. 2018 Sep;29(8):717-724
[2] Wu X, et al. Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma. Blood. 2019 Jul 25;134(4):363-373

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4731 mL
- 12.3656 mL
- 24.7312 mL
- 5 mM
- 0.4946 mL
- 2.4731 mL
- 4.9462 mL
- 10 mM
- 0.2473 mL
- 1.2366 mL
- 2.4731 mL

技术信息

CAS号

1034895-42-5

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H13FN2O5

运输

蓝冰

分子量

404.35

别名

Elraglusib

溶解度

DMSO	81.0 mg/mL (200.3 mM)
Water	Insoluble
Ethanol	Insoluble

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