|8-(5-(5,7-二羟基-4-氧代-4H-苯并吡喃-2-基)-2-羟基苯基)-5,7-二羟基-2-(4-羟基苯基)-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 1617-53-4

穗花杉双黄酮 Catalog No. CSN10276

Synonyms: Didemethyl-ginkgetin;NSC 295677;38Biapigenin

Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM.

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技术信息

生物活性

描述Amentoflavone is the main component of Selaginella tamariscina widely known as an oriental traditional medicinal stuff that has been known to have a variety of medicinal effects such as the induction of apoptosis, antimetastasis, and anti-inflammation. Amentoflavone could play a positive role in the inhibition of various diseases associated with autophagy and the modulation of p53^[3]. Amentoflavone affects epileptogenesis and exerts neuroprotective effects by inhibiting the NLRP3 inflammasome and, thus, mediating the inflammatory process in PTZ(pentylenetetrazole)-induced kindling mice and LPS(lipopolysaccharide)-induced BV2 microglial cells^[4]. In vivo, the tumor growth was suppressed by AF (Amentoflavone) in a dose-dependent manner. The level of MDA (malondialdehyde) in the tumor tissue was increased while the level of GSH (reduced glutathione) in tumor tissue was decreased by AF in a dose-dependent manner. Furthermore, the expression of LC3B, Beclin1, ATG5, ATG7 were increased, and the expression of FTH (ferritin heavy chain) were decreased by AF in a dose-dependent manner in vivo^[5]. Amentoflavone inhibits HCC (hepatocellular carcinoma) progression through suppression of ERK(extracellular signal-regulated kinase )/NF-ĸB (nuclear factor-kappaB) signaling^[6]. In addition, amentoflavone improves the osteogenesis of hMSCs (human mesenchymal stem cells) through the JNK and p38 MAPK pathway^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8572 mL
- 9.2858 mL
- 18.5716 mL
- 5 mM
- 0.3714 mL
- 1.8572 mL
- 3.7143 mL
- 10 mM
- 0.1857 mL
- 0.9286 mL
- 1.8572 mL

技术信息

CAS号

1617-53-4

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C30H18O10

运输

蓝冰

分子量

538.46

别名

Didemethyl-ginkgetin;NSC 295677;38Biapigenin;穗花杉双黄酮

溶解度

DMSO	110.0 mg/mL (204.3 mM)
Water	90.0 mg/mL (167.1 mM)

动物实验配方

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穗花杉双黄酮 Catalog No. CSN10276

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