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CAS No.: 484-12-8

蛇床子素 Catalog No. CSN18828

Synonyms: 蛇床子素;Osthol;NSC 31868

Osthole, an O-methylated coumarin, is a histamine H1 receptor inhibitior. It exhibits immunomodulatory, antioxidative and anti-inflammatory activities.

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400-920-2911

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生物活性

描述Osthole, a natural coumarin found in traditional Chinese medicinal herbs, has therapeutic potential in the treatment of various diseases. Mice were administered osthole (100 mg/kg/d, ip) for 3 d, then on the fourth day APAP (Acetaminophen) (300 mg/kg, ip) was co-administered with osthole. Compared with the mice treated with APAP alone, osthole pretreatment significantly reduced serum MDA levels and hepatic H2O2 levels, and improved liver GSH levels and the GSSG-to-GSH ratio. In cultured murine primary hepatocytes and Raw264.7 cells, however, osthole (40 μM) did not alleviate APAP-induced cell death, but it significantly suppressed APAP-caused elevation of inflammatory cytokines^[3]. Mice were injected with osthole (100 mg/kg, ip) or vehicle, followed by TMX (Tamoxifen, 90 mg/kg, ip) 24 h later. Osthole prevents TMX hepatotoxicity by suppressing p38 activation and subsequently reducing TMX-induced oxidative damage^[4]. Pretreatment with osthole (100 mg/kg/d, ip, 3d) significantly ameliorated the clinical scores, colon length shortening, colonic histopathological changes and the expression of inflammatory mediators in TNBS-induced colitis. In mouse peritoneal macrophages, pretreatment with osthole (50 μM) significantly attenuated the LPS-induced elevation of cytokines at the mRNA level^[5]. Osthole can be considered as a potential component of the treatment of Osteoarthritis, for it possesses a cartilage protective effect, as well as anti-inflammation, analgesic, and movement improving effects^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0936 mL
- 20.4678 mL
- 40.9357 mL
- 5 mM
- 0.8187 mL
- 4.0936 mL
- 8.1871 mL
- 10 mM
- 0.4094 mL
- 2.0468 mL
- 4.0936 mL

技术信息

CAS号

484-12-8

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H16O3

运输

蓝冰

分子量

244.29

别名

蛇床子素;Osthol;NSC 31868

溶解度

DMSO	98.0 mg/mL (401.2 mM)

动物实验配方

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