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CAS No.: 6665-86-7

7-Hydroxyflavone/7羟基黄酮 Catalog No. CSN25205

Synonyms: NSC 94258;7-hydroxy-2-Phenylchromone;7羟基黄酮

7-Hydroxyflavone is a flavonoid isolated from M. indica, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway .

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生物活性

描述7-hydroxflavone can protect renal cells from nicotine induced cytotoxicity through ERK/Nrf2/HO-1 pathway^[2]. 7-Hydroxflavone could quench the intrinsic fluorescence of HEWL (hen egg white lysozyme) through static quenching mechanism while the binding affinity of 7HF (7-Hydroxyflavone) was found to be greater than 3HF under experimental conditions. The binding constant (Kb) values were estimated to be in the order of 104 M-1 and decreased with the rise in temperature. The flavonoid was found to inhibit the enzymatic activity of HEWL^[4]. In addition, 7-Hydroxyflavone and its phosphate ester (FIP) were predicted to bind with EV71 (Enterovirus 71) 3Cpro. In an in vitro protease inhibition assay, FIP inhibited EV71 3Cpro protease activity. It was highly active against EV71, protecting cells from EV71 infection. Replication of viral RNA and formation of EV71 plaque were all strongly inhibited in cells^[5].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1975 mL
- 20.9874 mL
- 41.9748 mL
- 5 mM
- 0.8395 mL
- 4.1975 mL
- 8.3950 mL
- 10 mM
- 0.4197 mL
- 2.0987 mL
- 4.1975 mL

技术信息

CAS号	6665-86-7	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H10O3	运输	蓝冰
分子量	238.24	别名	NSC 94258;7-hydroxy-2-Phenylchromone;7羟基黄酮

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