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CAS No.: 486-66-8

大豆素 Catalog No. CSN17329

Synonyms: Isoflavone;Daidzeol;Isoaurostatin

Daidzein can act as an inhibitor of tyrosine kinase and an activator of estrogen receptor. It is inactive analogue of genistein.

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技术信息

生物活性

描述Daidzein, often found in nuts, fruits, soybean and soybean products, belongs to isoflavone phytoestrogens. Daidzein is considered chemoprotective and can be used as an alternative therapy for a wide range of hormonal disorders, including several cancer types^[3]. In vitro, daidzein inhibited choriocarcinoma cell lines JAR and JEG-3 cells growth in a time- and dose-dependent (12.5 - 400 µM) manner and cell cycle was arrested at G1 phase through suppressing ERK pathway^[4]. Daidzein significantly enhanced alkaline phosphatase (ALP) activity dose-dependently, with a maximal role at a dose of 10 μg/mL (P<0.05) in OCT1 cells. Daidzein (10 μg/mL) stimulated osteoblast proliferation and differentiation through stimulating the activation of the BMP-2/Smads pathway^[5]. In vivo, C57BL/6J mice administered with western-style diet (WD) + genistein and WD + daidzein showed a robust decrease in body weight gain by 40% and 19%, respectively (p < 0.05), compared to WD-fed mice. Genistein reduced energy intake by 26%, and daidzein decreased energy intake by 8% (p < 0.05)^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01232751	Postmenopause	Not Applicable	Completed	-	Netherlands ... more >> Wageningen University Wageningen, Gelderland, Netherlands, 6703 HD Collapse <<
NCT02026518	Irritable Bowel Disease	Phase 4	Completed	-	Iran, Islamic Republic of ... more >> Gastrointestinal Clinics of Tehran University of Medical Sciences Tehran, Iran, Islamic Republic of Collapse <<
NCT00669656	Prostate Cancer	Phase 2	Completed	-	United States, California ... more >> USC/Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9333 mL
- 19.6667 mL
- 39.3333 mL
- 5 mM
- 0.7867 mL
- 3.9333 mL
- 7.8667 mL
- 10 mM
- 0.3933 mL
- 1.9667 mL
- 3.9333 mL

技术信息

CAS号

486-66-8

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H10O4

运输

蓝冰

分子量

254.24

别名

Isoflavone;Daidzeol;Isoaurostatin;黄豆苷元;大豆苷元

溶解度

DMSO	50.0 mg/mL (196.7 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01232751	Postmenopause	Not Applicable	Completed	-	Netherlands ... more >> Wageningen University Wageningen, Gelderland, Netherlands, 6703 HD Collapse <<
NCT02026518	Irritable Bowel Disease	Phase 4	Completed	-	Iran, Islamic Republic of ... more >> Gastrointestinal Clinics of Tehran University of Medical Sciences Tehran, Iran, Islamic Republic of Collapse <<
NCT00669656	Prostate Cancer	Phase 2	Completed	-	United States, California ... more >> USC/Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 Collapse <<
NCT02174666	Osteopenia Os... more >>teoporosis Collapse <<	Not Applicable	Unknown	September 2016	Denmark ... more >> Aarhus University Hospital Aarhus, Central Jutland Region, Denmark, 8000 Collapse <<
NCT01048606	Overweight	Phase 4	Completed	-	Canada, Quebec ... more >> Centre de recherche sur le vieillissement du CSSS-IUGS Sherbrooke, Quebec, Canada, J1H 4C4 Collapse <<
NCT01048606	-	-	Completed	-	-
NCT01463436	Cardiovascular Disease ... more >> Osteoporosis Collapse <<	Phase 3	Completed	-	Indonesia ... more >> Trisakti University Jakarta, DKI Jakarta, Indonesia Collapse <<
NCT01497977	Low Serum Lipid Levels	Phase 4	Completed	-	Serbia ... more >> Ultramedica Clinic, American Medical Academy Belgrade, Serbia, 11000 Collapse <<
NCT02309801	Healthy	Phase 1	Completed	-	Spain ... more >> Parc de Salut Mar. Barcelona, Spain, 08003 Collapse <<
NCT00366860	Osteoporosis ... more >>Cardiovascular Diseases Collapse <<	Phase 1	Completed	-	United States, Michigan ... more >> University of Michigan Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT03099590	Alcohol Drinking ... more >> Alcohol Use Disorder Alcohol Abstinence Collapse <<	Phase 2	Recruiting	March 1, 2020	United States, Massachusetts ... more >> McLean Hospital Recruiting Belmont, Massachusetts, United States, 02478 Contact: Scott E Lukas, PhD 617-855-2767 Slukas@mclean.harvard.edu Contact: Wendy Tartarini, MA 617-855-2174 Wtartarini@mclean.harvard.edu Collapse <<
NCT00491595	Drug Toxicity	Phase 1	Completed	-	-
NCT00924339	Familial Hypercholesterolemia	Not Applicable	Unknown	September 2011	Austria ... more >> Division of Nutrition and Metabolism, Department of Pediatrics, Medical University of Vienna Not yet recruiting Vienna, Austria, 1090 Contact: Alexandra Kreißl, Mag.rer.nat 0034140400 ext 2051 alexandra.kreissl@meduniwien.ac.at Principal Investigator: Alexandra Kreißl, Mag.rer.nat Collapse <<
NCT00179556	Menopausal Symptoms	Phase 2 Phase 3	Completed	-	United States, Massachusetts ... more >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Collapse <<
NCT00661856	Osteoporosis	Not Applicable	Completed	-	United States, Nebraska ... more >> Creighton University Medical Center Omaha, Nebraska, United States, 68131 Collapse <<
NCT03561662	Menopause	Not Applicable	Completed	-	United Kingdom ... more >> Human Intervention Studies Unit, Ulster University Coleraine, Co.Londonderry, United Kingdom, BT52 1SA Collapse <<
NCT00951912	Type 2 Diabetes Mellitus	Not Applicable	Completed	-	China, Guangdong ... more >> The First Affiliated Hospital, Sun Yat-sen University Guangzhou, Guangdong, China, 510080 Collapse <<
NCT01556737	Postmenopause	Not Applicable	Completed	-	Netherlands ... more >> Wageningen University Wageningen, Gelderland, Netherlands, 6700 EV Collapse <<
NCT01270737	Hypertension	Not Applicable	Unknown	December 2012	China ... more >> Center of Research and Promotion of Women's Health Not yet recruiting Hong Kong, China Collapse <<
NCT00951912	-	-	Completed	-	-

大豆素 Catalog No. CSN17329

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