|7,8-二羟基-2-苯基-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 38183-03-8

7,8-二羟基黄酮水合物 Catalog No. CSN10171

Synonyms: 7;8-DHF;7,8-DHF

7,8-Dihydroxyflavone acts as an agonist of TrkB receptor with Kd of 320 nM with neuroprotective effect.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Trk Receptor B

Kd:320nM
描述7,8-Dihydroxyflavone (7,8-DHF) is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). 7,8-DHF (500 nM) protected primary neurons from Aβ-induced toxicity and promoted dendrite branching and synaptogenesis. Chronic oral administration of 7,8-DHF activated TrkB signaling and prevented Aβ deposition in transgenic mice that coexpress five familial Alzheimer's disease mutations (5XFAD mice). Moreover, 7,8-DHF inhibited the loss of hippocampal synapses, restored synapse number and synaptic plasticity, and prevented memory deficits^[3]. 7,8-DHF activated the Nrf2 signaling pathway in primary chondrocytes^[4]. 7,8-DHF might be capable of alleviating the jejunal contractile damage caused by IR (ischaemia-reperfusion) through activation of TrkB and augmentation of M3 expression^[5]. 7,8-DHF (5 mg/kg; i.p.) administration conferred beneficial effects against alcohol and HFD-induced memory deficit via its unique antioxidant, anti-inflammatory, anti-apoptotic potential, along with the activation of TrkB/BDNF signaling pathway in the hippocampus^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9333 mL
- 19.6667 mL
- 39.3333 mL
- 5 mM
- 0.7867 mL
- 3.9333 mL
- 7.8667 mL
- 10 mM
- 0.3933 mL
- 1.9667 mL
- 3.9333 mL

技术信息

CAS号

38183-03-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H10O4

运输

蓝冰

分子量

254.24

别名

7;8-DHF;7,8-DHF;DHF;7,8-二羟基黄酮

溶解度

DMSO	49.0 mg/mL (192.7 mM)
Water	Insoluble
Ethanol	1.0 mg/mL (3.9 mM)

动物实验配方

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