|6-氨基吡啶-3-甲酰胺|CsnPharm

CAS No.: 329-89-5

6-氨基烟酰胺 Catalog No. CSN25640

Synonyms: 6AN;6-Aminopyridine-3-carboxamide;NSC 21206

6-Aminonicotinamide is an inhibitor of the NADP+-dependent enzyme with Ki value of 0.46μM.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM) ^[1]. Immediately following 45 min i.v. infusion of [2-(13)C]glucose to controls and 6-AN-treated (50 mg/kg i.p. given 4 h previously) Sprague-Dawley rats (n = 5 for both groups), metabolism was arrested using freeze-funnel fixation. Chloroform-methanol-water neocortical extracts from animals administered with 6-AN demonstrated elevated levels of 6-phosphogluconate and 6-phosphoglucono-delta-lactone, both of which demonstrated labeling through metabolism of [2-(13)C]glucose^[2]. 6-Aminonicotinamide (100 nM; 7 days) causes a significant decrease in the human AR+, hormone-sensitive prostate cancer cell lines LNCaP and LAPC4, as well as the CRPC-derivative C4-2 and 22Rv1 cell models. 6-Aminonicotinamide (100 nM ± 10 nM R1881 as indicated for 3 days) increases both basal- and R1881-mediated ROS levels, suggesting 6-Aminonicotinamide is blocking the cells' antioxidant defense. 6-Aminonicotinamide also increases ROS levels in C4-2 cells^[3]. 6-Aminonicotinamide (20 mg/kg; i.p.; thress times; days 1, 10 or 11, and 21) alone induces a small but significant tumor growth delay (4.3+/-0.8 days). Treatment with 6-Aminonicotinamide followed by radiation induces a tumor growth delay of 57.0+/-3.8 days in CD8F1 breast tumor model^[4].
参考文献

[1] Almugadam SH, Trentini A, Maritati M, Contini C, Rugna G, Bellini T, Manfrinato MC, Dallocchio F, Hanau S. Influence of 6-aminonicotinamide (6AN) on Leishmania promastigotes evaluated by metabolomics: Beyond the pentose phosphate pathway. Chem Biol Interact. 2018 Oct 1;294:167-177
[2] Tyson RL, Perron J, Sutherland GR. 6-Aminonicotinamide inhibition of the pentose phosphate pathway in rat neocortex. Neuroreport. 2000 Jun 26;11(9):1845-8
[3] Tsouko E, Khan AS, White MA, Han JJ, Shi Y, Merchant FA, Sharpe MA, Xin L, Frigo DE. Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth. Oncogenesis. 2014 May 26;3(5):e103
[4] Koutcher JA, Alfieri AA, Matei C, Meyer KL, Street JC, Martin DS. Effect of 6-aminonicotinamide on the pentose phosphate pathway: 31P NMR and tumor growth delay studies. Magn Reson Med. 1996 Dec;36(6):887-9

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.2919 mL
- 36.4593 mL
- 72.9186 mL
- 5 mM
- 1.4584 mL
- 7.2919 mL
- 14.5837 mL
- 10 mM
- 0.7292 mL
- 3.6459 mL
- 7.2919 mL

技术信息

CAS号

329-89-5

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H7N3O

运输

蓝冰

分子量

137.14

别名

6AN;6-Aminopyridine-3-carboxamide;NSC 21206;SR 4388;6-氨基烟酰胺

溶解度

DMSO	25.0 mg/mL (182.3 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

6-氨基烟酰胺 Catalog No. CSN25640

靶点选择性

请登录您的专属账户

确认信息