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CAS No.: 2174-59-6

5-O-Demethylnobiletin Catalog No. CSN13542

Synonyms: 5-Demethylnobiletin;5-hydroxy Nob;NSC 618927

5-O-Demethylnobiletin, a flavonoid isolated from the peel of Citrus nobilis Lour., shows a certain inhibitory effect on DPP-IV enzyme.

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400-920-2911

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技术信息

生物活性

描述5-O-Demethylnobiletin reduced the oedema formation, cell infiltration, and tissue damage in the inflammation induced by TPA (12- O-tetradecanoylphorbol 13-acetate) in mouse ears, along with the acute oedema induced by carrageenan in mouse paws and the acute PLA (2)-induced (phospholipase A (2)) oedema in mouse paws^[2]. 5-Demethylnobiletin and gardenin A (10 - 20 μM) potently induce neurite outgrowth in PC12 cells, accompanied by the expression of neuronal differentiation and synapse formation marker proteins, growth-associated protein-43 (GAP-43), and synaptophysin^[3]. Three novel metabolites were identified in mice after oral administration of 5-demethylniobiletin. These metabolites exhibited strong inhibitory effects against human colon cancer cells. For example, metabolites (2 - 4) showed IC50 of 0.12, 5.5, and 4.2 μM in SW620 cells, respectively, while 5-demethylnobiletin at 10 μM only caused 37% inhibition after 72 h of treatment^[4].
参考文献

[1] Bas E, Recio MC, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42.
[2] Bas E, Recio MC, Giner RM, Máñez S, Cerdá-Nicolás M, Ríos JL. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006;72(2):136-142
[3] Chiu SP, Wu MJ, Chen PY, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013;61(39):9453-9463
[4] Zheng J, Song M, Dong P, et al. Identification of novel bioactive metabolites of 5-demethylnobiletin in mice. Mol Nutr Food Res. 2013;57(11):1999-2007

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5749 mL
- 12.8744 mL
- 25.7488 mL
- 5 mM
- 0.5150 mL
- 2.5749 mL
- 5.1498 mL
- 10 mM
- 0.2575 mL
- 1.2874 mL
- 2.5749 mL

技术信息

CAS号

2174-59-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H20O8

运输

蓝冰

分子量

388.37

别名

5-Demethylnobiletin;5-hydroxy Nob;NSC 618927

溶解度

DMSO	32.0 mg/mL (82.4 mM)

动物实验配方

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5-O-Demethylnobiletin Catalog No. CSN13542

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