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CAS No.: 4008-48-4

硝羟喹啉 Catalog No. CSN10393

Synonyms: 8-Hydroxy-5-nitroquinoline;5-Nitro-8-quinolinol;5-Nitroquinolin-8-Ol

Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline is currently repurposed for the treatment of urinary tract infection, which active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infection. Nitroxoline showed a broad antimicrobial spectrum, with inhibition zone diameters and MICs of nitroxoline well below the EUCAST breakpoint for E. coli for most organisms (≤16mg/ml). Nitroxoline is active against the bacteria E. coli, S. aureus, E. faecalis, K. pneumoniae, and P. mirabilis in vitro (MIC90s = 4, 4, 8, 8, and 8 mg/L, respectively)^[3]. Nitroxoline inhibits the growth of human U87 and U251 glioma, A549 lung, and PC3 prostate cancer cells (IC50s = 50, 6, 38, and 23 μg/ml, respectively)^[4]. In vivo, it reduces tumor growth in a PTEN- and KRAS-driven glioma mouse model when administered at a dose of 80 mg/kg per day. Nitroxoline also inhibits the interaction between the first bromodomain of bromodomain-containing protein 4 (BRD4) with acetylated histone H4 with an IC50 value of 0.98 μM^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.2589 mL
- 26.2943 mL
- 52.5885 mL
- 5 mM
- 1.0518 mL
- 5.2589 mL
- 10.5177 mL
- 10 mM
- 0.5259 mL
- 2.6294 mL
- 5.2589 mL

技术信息

CAS号

4008-48-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H6N2O3

运输

蓝冰

分子量

190.16

别名

8-Hydroxy-5-nitroquinoline;5-Nitro-8-quinolinol;5-Nitroquinolin-8-Ol;5-Nitro-8-Hydroxyquinoline;5-nitrox;5-NOK;Cysto-saar plus;Nibiol;硝羟喹啉;硝唑啉

溶解度

DMSO	128.0 mg/mL (673.1 mM)
Water	insoluble

动物实验配方

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