CAS No.: 122320-73-4
罗格列酮 Catalog No. CSN12512
Synonyms: BRL 49653;HSDB-7555;TDZ-01
Rosiglitazone is a selective agonist of PPARγ with EC50 of 60 nM, and has no effect on PPARα and PPARβ. It is an insulin sensitizing and potent antihyperglycemic agent.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 PPARγ
Kd:43nM- 描述
- 作用机制
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00143624 Atherosclerosis ... more >> HIV Infections Collapse << Not Applicable Completed - Canada, British Columbia ... more >> St. Paul's Hospital Vancouver, British Columbia, Canada, V6Z 1Y6 Collapse << NCT00116831 Atherosclerosis Phase 3 Completed - - NCT01060566 Cystic Fibrosis Phase 1 Completed - United States, Florida ... more >> Covan CRU, Inc. Daytona Beach, Florida, United States, 32117 Collapse << - 更多
- 参考文献
- [1] Lehmann JM, Moore LB, et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem. 1995;270(22):12953-6.
- [2] Rong JX, Klein JL, et al. Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated Murine 3T3-L1 and C3H/10T1/2 Adipocytes. PPAR Res. 2011.
- [3] Edvardsson U, Bergström M, et al. Rosiglitazone (BRL49653), a PPARgamma-selective agonist, causes peroxisome proliferator-like liver effects in obese mice. J Lipid Res. 1999;40(7):1177-84.
- [4] Xiong N, Sun F, et al. Effect of Rosiglitazone Maleate on inflammation following cerebral ischemia/reperfusion in rats. J Huazhong Univ Sci Technolog Med Sci. 2007 Jun;27(3):295-8.
- [5] Umrani DN, Banday AA, et al. Rosiglitazone treatment restores renal dopamine receptor function in obese Zucker rats. Hypertension. 2002 Dec;40(6):880-5.
- [6] Cellai I, Petrangolini G, et al. In vivo effects of rosiglitazone in a human neuroblastoma xenograft. Br J Cancer. 2010 Feb 16;102(4):685-92.
- [7] Birrell MA, Patel HJ, et al. PPAR-gamma agonists as therapy for diseases involving airway neutrophilia. Eur Respir J. 2004 Jul;24(1):18-23.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 122320-73-4 | 储存条件 |
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| 分子式 | C18H19N3O3S | 运输 | 蓝冰 | |||||||||||
| 分子量 | 357.43 | 别名 | BRL 49653;HSDB-7555;TDZ-01;罗格列酮 | |||||||||||
| 溶解度 |
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动物实验配方 |
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| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT00143624 | Atherosclerosis ... more >> HIV Infections Collapse << | Not Applicable | Completed | - | Canada, British Columbia ... more >> St. Paul's Hospital Vancouver, British Columbia, Canada, V6Z 1Y6 Collapse << |
| NCT00116831 | Atherosclerosis | Phase 3 | Completed | - | - |
| NCT01060566 | Cystic Fibrosis | Phase 1 | Completed | - | United States, Florida ... more >> Covan CRU, Inc. Daytona Beach, Florida, United States, 32117 Collapse << |
| NCT00169923 | Chronic Kidney Disease ... more >> Inflammation Collapse << | Phase 2 Phase 3 | Withdrawn(it was not possible ... more >>to recruit any patient in the study) Collapse << | May 2009 | Netherlands ... more >> Medisch Centrum Haaglanden Den Haag, Z-Holland, Netherlands, 2512va Haga Ziekenhuis Den Haag, Z-Holland, Netherlands, 2545ch Collapse << |
| NCT00116831 | - | - | Completed | - | - |
| NCT00154011 | Healthy Subjects | Not Applicable | Completed | - | Germany ... more >> Institute of Clinical Pharmacology Dresden, Germany, 01307 Collapse << |
| NCT00567593 | - | - | Completed | - | - |
| NCT01088594 | Type 2 Diabetes Mellitus | Phase 1 | Completed | - | United Kingdom ... more >> S337.1.004 Site # London, United Kingdom Collapse << |
| NCT00567593 | Inflammatory Bowel Disease | Phase 4 | Completed | - | United States, Pennsylvania ... more >> University of Pennsylvania Clinical and Translational Research Center Philadelphia, Pennsylvania, United States, 19104 Collapse << |
| NCT01402076 | Healthy Volunteers | Phase 1 | Completed | - | United States, Missouri ... more >> Bio-Kinetic Clinical Applications Springfield, Missouri, United States, 65802 Collapse << |
| NCT00166803 | Diabetes Mellitus, Atheroscler... more >>osis Collapse << | Not Applicable | Suspended(no fund) | - | Taiwan ... more >> National Taiwan University Hospital Taipei, Taiwan, 10012 Collapse << |
| NCT00367055 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | - |
| NCT00098852 | Head and Neck Cancer | Phase 2 | Unknown | - | United States, California ... more >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 Collapse << |
| NCT00372086 | Type 1 Diabetes ... more >> Puberty: >Tanner 2 Breast Development or Testis >4ml Collapse << | Phase 4 | Completed | - | Australia, New South Wales ... more >> Sydney Children's Hospital Sydney, New South Wales, Australia, 2038 Collapse << |
| NCT00318630 | Asthma | Phase 1 | Completed | - | New Zealand ... more >> GSK Investigational Site Wellington, New Zealand, 6035 Collapse << |
| NCT00115661 | Endometriosis | Phase 2 | Terminated(Due to the meta-ana... more >>lysis about CV adverse effects of rosiglitazone.) Collapse << | - | United States, Michigan ... more >> University of Michigan Health System Ann Arbor, Michigan, United States, 48109 Collapse << |
| NCT00225225 | Diabetes Mellitus, Type 2 | Not Applicable | Terminated(due to published da... more >>ta on Rosiglitazone) Collapse << | - | United States, California ... more >> Stanford University School of Medicine Stanford, California, United States, 94305 Collapse << |
| NCT00309309 | Kidney Transplant | Phase 2 | Completed | - | Italy ... more >> Clinical Research Center for Rare Diseases Ranica, Bergamo, Italy, 24020 Collapse << |
| NCT00831129 | Pre-diabetes | Phase 2 Phase 3 | Completed | - | United States, Illinois ... more >> University of Chicago Chicago, Illinois, United States, 60637 Collapse << |
| NCT00492700 | Non Alcoholic Steatohepatitis | Phase 2 | Completed | - | France ... more >> Service d'hépatogastroenérologie, Hôpital Pitié Salpêtrière Paris, France, 75013 Collapse << |
| NCT00953498 | Type 2 Diabetes | Phase 4 | Completed | - | France ... more >> Service Endocrinologie-diabétologie, Hôpital du Bocage CHU Dijon, France, 21000 Collapse << |
| NCT00367055 | - | - | Completed | - | - |
| NCT00130286 | HIV-Associated Lipodystrophy S... more >>yndrome Insulin Resistance HIV Infections Metabolic Syndrome X Body Weight Changes Collapse << | Phase 1 Phase 2 | Completed | - | United States, New York ... more >> AIDS Community Research Initiative of America (ACRIA) New York, New York, United States, 10018 Cornell HIV Clinical Trials Unit, Weill Medical College of Cornell University New York, New York, United States, 10021 St. Luke's-Roosevelt Hospital Center New York, New York, United States, 10025 Columbia University College of Physicians and Surgeons New York, New York, United States, 10032 Collapse << |
| NCT00364221 | Metabolic Syndrome ... more >> Insulin Resistance Collapse << | Phase 4 | Completed | - | United States, Colorado ... more >> University of Colorado at Denver and Health Sciences Center General Clinical Research Center Denver, Colorado, United States, 80262 Collapse << |
| NCT00123643 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | United States, Minnesota ... more >> St. Paul Heart Clinic St. Paul, Minnesota, United States, 55102 Collapse << |
| NCT00130286 | - | - | Completed | - | - |
| NCT00452166 | Chronic Kidney Disease ... more >> Insulin Resistance Collapse << | Phase 3 | Terminated(it was not possible... more >> to recruit new patients anymore) Collapse << | - | Netherlands ... more >> LUMC Leiden, Netherlands Collapse << |
| NCT00831129 | - | - | Completed | - | - |
| NCT00123643 | - | - | Completed | - | - |
| NCT00522470 | Type 2 Diabetes Mellitus ... more >> Obesity Collapse << | Phase 4 | Completed | - | Turkey ... more >> Baskent University Hospital Department of Endocrinology Ankara, Bahçelievler, Turkey, 06490 Collapse << |
| NCT00324675 | Type 2 Diabetes ... more >> Overt Diabetic Nephropathy Collapse << | Not Applicable | Completed | - | Germany ... more >> University hospital Dresden Dresden, Germany, 01307 Collapse << |
| NCT00348140 | Alzheimer's Disease | Phase 3 | Completed | - | - |
| NCT00484419 | Type 2 Diabetes ... more >> Hyperlipidemia Collapse << | Phase 3 | Completed | - | United States, California ... more >> La Mesa, California, United States Los Angeles, California, United States Los Gatos, California, United States San Antonio, California, United States United States, Florida Chiefland, Florida, United States United States, Indiana Gary, Indiana, United States United States, Maryland Baltimore, Maryland, United States United States, Michigan Dearborn, Michigan, United States W. Bloomfield, Michigan, United States United States, Nevada Las Vegas, Nevada, United States United States, New York Yonkers, New York, United States United States, North Carolina Lexington, North Carolina, United States Winston-Salem, North Carolina, United States United States, Ohio Munroe Falls, Ohio, United States Zaneville, Ohio, United States United States, Oregon Portland, Oregon, United States United States, Pennsylvania Jersey Shore, Pennsylvania, United States United States, South Carolina Clemson, South Carolina, United States United States, Tennessee Harriman, Tennessee, United States United States, Texas Dallas, Texas, United States Collapse << |
| NCT00379769 | - | - | Completed | - | - |
| NCT00324675 | - | - | Completed | - | - |
| NCT00306644 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | Sweden ... more >> GSK Investigational Site Malmö, Sweden, SE-205 02 Collapse << |
| NCT00484419 | - | - | Completed | - | - |
| NCT00348140 | - | - | Completed | - | - |
| NCT00499707 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00675740 | Impaired Glucose Tolerance | Phase 4 | Completed | - | - |
| NCT00314561 | Metabolic Syndrome | Phase 4 | Completed | - | Korea, Republic of ... more >> Korea University Anam Hospital Seoul, Korea, Republic of, 136-705 Collapse << |
| NCT00123227 | Diabetes Mellitus, Type 2 ... more >> Vascular Diseases Hypertension Collapse << | Phase 3 | Unknown | - | United Kingdom ... more >> Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital London, United Kingdom, SW3 6NP St Mary's NHS Trust London, United Kingdom, W2 1NY Collapse << |
| NCT00551564 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | United States, California ... more >> GSK Investigational Site Chula Vista, California, United States, 91911 Collapse << |
| NCT00285142 | Healthy | Not Applicable | Completed | - | France ... more >> Centre d'Investigation Clinique Montpellier, France, 34295, cedex 5 Collapse << |
| NCT00511823 | Nausea and Vomiting, Chemother... more >>apy-Induced Collapse << | Phase 1 | Completed | - | United States, Indiana ... more >> GSK Investigational Site Evansville, Indiana, United States, 47714 Collapse << |
| NCT00194896 | Type 2 Diabetes Mellitus | Not Applicable | Completed | - | United States, Washington ... more >> DVA Puget Sound Health Care System Seattle, Washington, United States, 98108 Collapse << |
| NCT00432679 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Japan ... more >> GSK Investigational Site Kumamoto, Japan, 862-0976 GSK Investigational Site Oita, Japan, 870-0039 Collapse << |
| NCT00178841 | Cutaneous T-cell Lymphoma ... more >> Mycosis Fungoides Sezary Syndrome Collapse << | Phase 2 | Completed | - | United States, Tennessee ... more >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232-5227 Collapse << |
| NCT00379769 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00178841 | - | - | Completed | - | - |
| NCT00318656 | Non-Insulin-Dependent Diabetes... more >> Mellitus Collapse << | Phase 4 | Completed | - | - |
| NCT00331487 | Diabetes Mellitus | Phase 3 | Completed | - | - |
| NCT00348309 | - | - | Completed | - | - |
| NCT01332370 | - | - | Completed | - | - |
| NCT00318656 | - | - | Completed | - | - |
| NCT00119496 | Asthma | Phase 2 Phase 3 | Completed | - | United Kingdom ... more >> Asthma Research Group, Gartnavel General Hospital Glasgow, Scotland, United Kingdom, G12 0YN Collapse << |
| NCT00279045 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00194896 | - | - | Completed | - | - |
| NCT00550420 | Alzheimer's Disease | Phase 3 | Terminated(Based on preliminar... more >>y parent study results) Collapse << | - | - |
| NCT00550420 | - | - | Terminated(Based on preliminar... more >>y parent study results) Collapse << | - | - |
| NCT00348309 | Alzheimer's Disease | Not Applicable | Completed | - | - |
| NCT00428090 | - | - | Completed | - | - |
| NCT00242619 | - | - | Completed | - | - |
| NCT00428090 | Alzheimer's Disease | Phase 3 | Completed | - | - |
| NCT00242619 | Depression Bi... more >>polar Disorder Insulin Resistance Collapse << | Not Applicable | Completed | - | United States, California ... more >> Stanford University School of Medicine Stanford, California, United States, 94305 Collapse << |
| NCT00490568 | - | - | Terminated(Based on preliminar... more >>y parent study results) Collapse << | - | - |
| NCT00135330 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, Arizona ... more >> Research Site Phoenix, Arizona, United States United States, California Research Site San Francisco, California, United States United States, Florida Research Site Jacksonville, Florida, United States Research Site Orlando, Florida, United States United States, Georgia Research Site Atlanta, Georgia, United States United States, Hawaii Research Site Honolulu, Hawaii, United States United States, Indiana Research Site Indianapolis, Indiana, United States United States, Massachusetts Research Site Boston, Massachusetts, United States Research Site Pittsfield, Massachusetts, United States United States, Minnesota Research Site Minneapolis, Minnesota, United States Research Site Rochester, Minnesota, United States United States, New York Research Site Bronx, New York, United States Research Site Syracuse, New York, United States United States, Ohio Research Site Cincinatti, Ohio, United States United States, Texas Research Site League City, Texas, United States Research Site New Braunfels, Texas, United States Research Site San Antonio, Texas, United States United States, Washington Research Site Renton, Washington, United States Research Site Spokane, Washington, United States Collapse << |
| NCT00490568 | Alzheimer's Disease | Phase 3 | Terminated(Based on preliminar... more >>y parent study results) Collapse << | - | - |
| NCT00333723 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
| NCT00349427 | Type 2 Diabetes Mellitus ... more >> Diabetes Mellitus, Type 2 Collapse << | Phase 3 | Completed | - | China, Jiangsu ... more >> GSK Investigational Site Nanjing, Jiangsu, China, 210008 China, Shanxi GSK Investigational Site Xian, Shanxi, China, 710032 China GSK Investigational Site Beijing, China, 100029 GSK Investigational Site Beijing, China, 100034 GSK Investigational Site Beijing, China, 100730 GSK Investigational Site Beijing, China, 100853 GSK Investigational Site Shanghai, China, 200001 GSK Investigational Site Shanghai, China, 200032 GSK Investigational Site Shanghai, China, 200233 GSK Investigational Site Tianjin, China, 300052 Collapse << |
| NCT00265148 | Alzheimer's Disease | Phase 2 | Completed | - | United States, Arizona ... more >> GSK Investigational Site Litchfield Park, Arizona, United States, 85340 GSK Investigational Site Phoenix, Arizona, United States, 85006 GSK Investigational Site Scottsdale, Arizona, United States, 85259 GSK Investigational Site Sun City, Arizona, United States, 85351 GSK Investigational Site Tucson, Arizona, United States, 85724 United States, California GSK Investigational Site Los Angeles, California, United States, 90024 United States, Massachusetts GSK Investigational Site Belmont, Massachusetts, United States, 02478 United States, Michigan GSK Investigational Site Ann Arbor, Michigan, United States, 48109 United States, North Carolina GSK Investigational Site Durham, North Carolina, United States, 27705 Canada, Quebec GSK Investigational Site Montreal, Quebec, Canada, H3T 1E2 GSK Investigational Site Montreal, Quebec, Canada, H4H 1R3 United Kingdom GSK Investigational Site Liverpool, United Kingdom, L9 7LJ GSK Investigational Site Manchester, United Kingdom, M20 3LJ GSK Investigational Site Swindon, United Kingdom, SN1 4HZ GSK Investigational Site West End, Southampton, United Kingdom, SO30 3JB Collapse << |
| NCT00135330 | - | - | Completed | - | - |
| NCT00612066 | Cushing's Disease | Phase 2 | Terminated(Low accrual and fun... more >>ding term ended) Collapse << | - | United States, California ... more >> Jonsson Comprehensive Cancer Center at UCLA Los Angeles, California, United States, 90095-1781 Collapse << |
| NCT00612066 | - | - | Terminated(Low accrual and fun... more >>ding term ended) Collapse << | - | - |
| NCT01574820 | Prediabetes C... more >>oronary Artery Disease Insulin Resistance Glucose Intolerance Collapse << | Phase 3 | Completed | - | - |
| NCT00274495 | Chronic Hepatitis C Infection ... more >> Fatty Liver Collapse << | Phase 4 | Terminated | - | United States, New York ... more >> Beth Israel Medical Center - Philipps Ambulatory Care Center New York, New York, United States, 10003 Collapse << |
| NCT00523913 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00413335 | - | - | Completed | - | - |
| NCT00500955 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00413335 | Obesity Impai... more >>red Glucose Tolerance Type 2 Diabetes Mellitus Collapse << | Not Applicable | Completed | - | United States, Connecticut ... more >> Yale School of Medicine New Haven, Connecticut, United States, 06520 Collapse << |
| NCT00688207 | Alzheimer's Disease | Phase 1 | Completed | - | Germany ... more >> GSK Investigational Site Berlin, Germany, 10117 Collapse << |
| NCT01872780 | Healthy | Phase 1 | Completed | - | - |
| NCT00290394 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | Turkey ... more >> Baskent University Ankara Hospital Ankara, Turkey, 06490 Collapse << |
| NCT01376063 | Healthy Adult Subjects | Phase 1 | Completed | - | - |
| NCT00285805 | Insulin Resistance | Not Applicable | Completed | - | Netherlands ... more >> Radboud University Nijmegen medical centre Nijmegen, Netherlands, 6500 HB Collapse << |
| NCT00004180 | Sarcoma | Phase 2 | Completed | - | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Collapse << |
| NCT00733174 | Impaired Glucose Tolerance | Phase 4 | Unknown | - | United States, Colorado ... more >> South Federal Family Practice Recruiting Denver, Colorado, United States, 80219 Contact: Annette Grissett, MA 303-934-2202 annetteg@roydurbin.com Contact: Stacey Mitchell, BSN, RN 303-399-8020 ext 2059 stacey.mitchell@va.gov Collapse << |
| NCT01209143 | Solid Cancers | Phase 1 | Completed | - | United States, California ... more >> Stanford, California, United States, 94305 United States, Michigan Detroit, Michigan, United States, 48201 United States, Texas Houston, Texas, United States, 77030 Collapse << |
| NCT01209143 | - | - | Completed | - | - |
| NCT00614874 | - | - | Completed | - | - |
| NCT01453049 | - | - | Terminated(US FDA/EMA/SFDA dec... more >>isions to rosiglitazone-containing medicines, ethic) Collapse << | - | - |
| NCT00381238 | Alzheimer's Disease | Phase 2 | Completed | - | United States, Arizona ... more >> GSK Investigational Site Litchfield Park, Arizona, United States, 85340 GSK Investigational Site Phoenix, Arizona, United States, 85006 GSK Investigational Site Sun City, Arizona, United States, 85351 United States, Massachusetts GSK Investigational Site Belmont, Massachusetts, United States, 02478 United States, Michigan GSK Investigational Site Ann Arbor, Michigan, United States, 48109 United States, North Carolina GSK Investigational Site Durham, North Carolina, United States, 27705 Canada, Quebec GSK Investigational Site Montreal, Quebec, Canada, H4H 1R3 Collapse << |
| NCT00381238 | - | - | Completed | - | - |
| NCT00424762 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | United States, Texas ... more >> University of Texas Southwestern Medical Center Dallas, Texas, United States, 75390-9034 Collapse << |
| NCT00306176 | Type II Diabetes Mellitus | Phase 4 | Completed | - | Greece ... more >> AHEPA University Hospital of Thessaloniki Thessaloniki, Greece, 54454 Collapse << |
| NCT01453049 | Diabetes Mellitus, Type 2 | Phase 3 | Terminated(US FDA/EMA/SFDA dec... more >>isions to rosiglitazone-containing medicines, ethic) Collapse << | - | China, Hubei ... more >> GSK Investigational Site Wuhan, Hubei, China, 430030 China, Jiangsu GSK Investigational Site Suzhou, Jiangsu, China, 215004 China, Liaoning GSK Investigational Site Dalian, Liaoning, China, 116027 China, Zhejiang GSK Investigational Site Hangzhou, Zhejiang, China, 310003 GSK Investigational Site Hangzhou, Zhejiang, China, 310009 China GSK Investigational Site Beijing, China, 100029 GSK Investigational Site Beijing, China, 100730 GSK Investigational Site Chongqing, China, 400016 GSK Investigational Site Shanghai, China, 200080 GSK Investigational Site Shenyang, China, 110003 GSK Investigational Site Tianjin, China, 300052 GSK Investigational Site Wuhan, China, 430022 Collapse << |
| NCT00231387 | Non-insulin-dependent Diabetes... more >> Mellitus Collapse << | Phase 3 | Completed | - | United Kingdom ... more >> GSK Clinical Trials Call Center London, United Kingdom, W2 1NY Collapse << |
| NCT01195259 | - | - | Completed | - | - |
| NCT00424762 | - | - | Completed | - | - |
| NCT00337350 | Schizophrenia | Phase 4 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Schizophrenia Program Boston, Massachusetts, United States, 02114 Collapse << |
| NCT00337350 | - | - | Completed | - | - |
| NCT00367744 | - | - | Completed | - | - |
| NCT01415128 | Erectile Dysfunction | Phase 1 | Completed | - | - |
| NCT00367744 | HIV Infections | Phase 2 | Completed | - | United States, Ohio ... more >> Cleveland Clinc Foundation Cleveland, Ohio, United States, 44106 University Hospitals of Cleveland/Case Western Reserve University Cleveland, Ohio, United States, 44141 Collapse << |
| NCT00616642 | Brain and Central Nervous Syst... more >>em Tumors Collapse << | Phase 2 | Terminated(low patient recruit... more >>ment) Collapse << | - | United States, California ... more >> Jonsson Comprehensive Cancer Center at UCLA Los Angeles, California, United States, 90095-1781 Collapse << |
| NCT00369174 | Oral Leukoplakia | Phase 2 | Completed | - | United States, New York ... more >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT00614874 | Asthma | Phase 2 | Completed | - | United States, Nebraska ... more >> Creighton University Medical Center, Department of Pulmonology and Critical Care Omaha, Nebraska, United States, 68131 Collapse << |
| NCT00207402 | Hepatitis C | Phase 4 | Completed | - | United States, Texas ... more >> Brooke Army Medical Center Ft. Sam Houston, Texas, United States, 78234 Collapse << |
| NCT01150981 | Metabolic Syndrome ... more >> Insulin Resistance Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> UMass Medical School Worcester, Massachusetts, United States, 01655 Collapse << |
| NCT00242593 | Mild Cognitive Impairment | Phase 2 | Unknown | December 2011 | United States, Arizona ... more >> Banner Alzheimer Institute Phoenix, Arizona, United States, 85006 United States, California UCLA Alzheimer's Disease Center Los Angeles, California, United States, 90095 United States, Washington University of Washington/VA Puget Sound Health Care System Seattle/Tacoma, Washington, United States, 98108 Collapse << |
| NCT01045590 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | Korea, Republic of ... more >> GSK Investigational Site Seoul, Korea, Republic of, 110-744 GSK Investigational Site Seoul, Korea, Republic of, 120-752 GSK Investigational Site Seoul, Korea, Republic of, 135-710 GSK Investigational Site Seoul, Korea, Republic of, 137-701 Collapse << |
| NCT00065065 | Ulcerative Colitis ... more >> Inflammatory Bowel Disease Collapse << | Phase 2 | Completed | - | United States, Georgia ... more >> Atlanta Gastroenterology Associates Atlanta, Georgia, United States, 30342 United States, Illinois University of Chicago Hospitals Chicago, Illinois, United States, 60637 United States, Maryland Metropolitan Gastroenterology Group Practice/Chevy Chase Clinical Research Chevy Chase, Maryland, United States, 20815 Maryland Digestive Diseases Research Laurel, Maryland, United States, 20707 Capitol Gastroenterology Consultants Silver Spring, Maryland, United States, 20901 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Minnesota Minnesota Gastroenterology Plymouth, Minnesota, United States, 55446 United States, New Jersey Atlantic Gastroenterology Associates Egg Harbor Township, New Jersey, United States, 08234 United States, North Carolina Wake Research Associates Raleigh, North Carolina, United States, 27612 United States, Ohio University Hospitals of Cleveland Cleveland, Ohio, United States, 44106 The Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Avamar Center for Endoscopy Warren, Ohio, United States, 44484 United States, Pennsylvania University of Pennsylvania - Presbyterian Medical Center Philadelphia, Pennsylvania, United States, 19104 Collapse << |
| NCT01150981 | - | - | Completed | - | - |
| NCT00065065 | - | - | Completed | - | - |
| NCT00819910 | Hypertriglyceridemia in Type 4... more >> Hyperlipidemia Non Diabetic Subjects With Normoglycemia Collapse << | Phase 4 | Terminated(Slow recruitment an... more >>d increase in deployment overseas limiting follow up) Collapse << | - | United States, Texas ... more >> Brooke Army Medical Center San Antonio, Texas, United States, 78234 Collapse << |
| NCT00169832 | Diabetes Coro... more >>nary Artery Bypass Grafting Collapse << | Phase 3 | Completed | - | Canada, Nova Scotia ... more >> QEII Health Sciences Center - Halifax Infirmary Halifax, Nova Scotia, Canada, B3H 3A7 Canada, Ontario Hamilton Health Sciences - Mc Master Clinic Hamilton, Ontario, Canada, L8L 2X2 Toronto General Hospital Toronto, Ontario, Canada, M5G 2C4 Canada, Quebec CRMSBC Bonaventure, Quebec, Canada, G0C 1E0 CHUM Notre-Dame Hospital Montreal, Quebec, Canada, H2L 4M1 Laval Hospital Sainte-Foy, Quebec, Canada, G1V 4G5 Spain Hospital Del Mar Barcelona, Spain Hospital Universitari Vall D'Hebron Barcelona, Spain Hospital Universitarion Son Dureta Palma de Mallorca, Spain Collapse << |
| NCT00616642 | - | - | Terminated(low patient recruit... more >>ment) Collapse << | - | - |
| NCT00370305 | Metabolic Syndrome ... more >> Impaired Glucose Tolerance Collapse << | Phase 2 | Completed | - | Germany ... more >> Charite, Campus Benjamin Franklin Berlin, Germany, 12200 Collapse << |
| NCT00609362 | - | - | Completed | - | - |
| NCT00746174 | Insulin Sensitivity | Phase 4 | Completed | - | United States, Texas ... more >> University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390 Collapse << |
| NCT00405015 | Ischemia-Reperfusion Injury ... more >> The Metabolic Syndrome Collapse << | Phase 2 | Completed | - | Netherlands ... more >> Clinical research Center Nijmegen Nijmegen, Netherlands, 6500 HB Collapse << |
| NCT00819910 | - | - | Terminated(Slow recruitment an... more >>d increase in deployment overseas limiting follow up) Collapse << | - | - |
| NCT01577095 | Type 2 Diabetes Mellitus With ... more >>Features of Insulin Resistance Collapse << | Phase 2 | Completed | - | Taiwan ... more >> Department of Integrative Chinese-Western Clinic, China Medical University Hospital Taichung, Taiwan, 404 Collapse << |
| NCT00609362 | Change in Bone Mineral Density... more >> Change in Bone Marrow Fat Content Collapse << | Phase 2 | Completed | - | Denmark ... more >> Aarhus University Hospital Aarhus, Denmark, 8000 C Collapse << |
| NCT00486187 | Type 2 Diabetes Mellitus | Not Applicable | Completed | - | Canada, Ontario ... more >> Partners Research Brampton, Ontario, Canada, L6V 1B4 Collapse << |
| NCT01406704 | NASH (Non-alcoholic Steato-hep... more >>atitis) Collapse << | Phase 4 | Terminated(because of withdraw... more >>al of Avandia sale due to its risks outweigh its benefits) Collapse << | December 2013 | - |
| NCT02526615 | Insulin Sensitivity ... more >> Type 2 Diabetes Collapse << | Phase 4 | Completed | - | Finland ... more >> Turku PET Centre Turku, Finland, 20520 Turku university hospital, PET center Turku, Finland, 20520 Turku PET Centre (Turku University Hospital) Turku, Finland, 20521 Collapse << |
| NCT00785213 | Healthy | Phase 1 | Completed | - | United States, Minnesota ... more >> Cetero Research East Grand Forks, Minnesota, United States, 56721 Collapse << |
| NCT00182052 | Adenocarcinoma of the Prostate... more >> Prostate Cancer Collapse << | Phase 3 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse << |
| NCT01706211 | Diabetes Mellitus Non Insulin ... more >>Dependent Oral Agent Therapy Collapse << | Phase 3 | Completed | - | Taiwan ... more >> National Taiwan University Hospital Taipei, Taiwan, 10002 Collapse << |
| NCT01100619 | Papillary Thyroid Cancer ... more >> Follicular Thyroid Cancer Huerthle Cell Thyroid Cancer Renal Cell Carcinoma Collapse << | Phase 1 | Completed | - | United States, California ... more >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Montefiore Medical Center Bronx, New York, United States, 10466 United States, Pennsylvania Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Texas The University of Texas M.D. Anderson Cancer Center Houston, Texas, United States, 77230 Collapse << |
| NCT03309319 | Pituitary Tumor | Not Applicable | Recruiting | December 31, 2018 | China, Shanghai ... more >> Huashan Hospital Recruiting Shanghai, Shanghai, China, 200040 Contact: Min He, Doctor +862152887027 mhe2004@263.net Principal Investigator: Zhaoyun Zhang, Professor Collapse << |
| NCT00785213 | - | - | Completed | - | - |
| NCT02694874 | Malaria | Not Applicable | Recruiting | December 2019 | Mozambique ... more >> Centro de Investigação em Saude da Manhiça Recruiting Manhiça, Maputo, Mozambique, CP1929 Contact: Quique Bassat, PhD Contact: Eusebio Macete, PhD Collapse << |
| NCT03492580 | - | - | Completed | - | United States, New Jersey ... more >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 Collapse << |
| NCT00975286 | - | - | Completed | - | - |
| NCT00975286 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | - |
| NCT02456428 | - | - | Completed | - | Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse << |
| NCT02475499 | - | - | Completed | - | Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse << |
| NCT00000620 | Atherosclerosis ... more >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease Collapse << | Phase 3 | Completed | - | United States, Minnesota ... more >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada Collapse << |
| NCT00885352 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | - |
| NCT00885352 | - | - | Completed | - | - |
| NCT00814255 | - | - | Completed | - | - |
| NCT00950534 | Diabetes Mellitus, Type 2 | Phase 4 | Terminated(due to poor recruit... more >>ment) Collapse << | - | Australia ... more >> Sanofi-Aventis Administrative Office Macquarie Park, Australia Collapse << |
| NCT02476760 | - | - | Completed | - | Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse << |
| NCT00000620 | - | - | Completed | - | - |
| NCT00386100 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
| NCT00481663 | Type II Diabetes Mellitus | Phase 2 | Completed | - | - |
| NCT00341406 | - | - | Completed | - | United States, Maryland ... more >> National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK), 9000 Bethesda, Maryland, United States, 20892 Collapse << |
| NCT00814255 | Focal Segmental Glomeruloscler... more >>osis Collapse << | Phase 2 | Completed | - | United States, Florida ... more >> University of Miami Miami, Florida, United States, 33136 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Kansas City, Kansas, United States, 66160 United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55901 United States, Missouri Children's Mercy Hospital Kansas City, Missouri, United States, 64108 Cardinal Glennon Children's Medical Center Saint Louis, Missouri, United States, 63104 United States, New York Steven and Alexandra Cohen Children's Medical Center of New York New Hyde Park, New York, United States, 11040 NYU Langone Medical Center New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 United States, North Carolina Carolinas Medical Center Charlotte, North Carolina, United States, 28207 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 Ohio State University Columbus, Ohio, United States, 43205 United States, Oregon Doernbecher Children's Hospital Portland, Oregon, United States, 97239 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Texas Texas Tech University El Paso, Texas, United States, 79905 Canada, Alberta University of Alberta Edmonton, Alberta, Canada, T6G 2R7 Collapse << |
| NCT00386100 | - | - | Completed | - | - |
| NCT00376870 | Coronary Atherosclerosis ... more >> Coronary Restenosis Diabetes Collapse << | Phase 3 | Unknown | April 2011 | Italy ... more >> Policlinico di Tor Vergata Not yet recruiting Rome, Italy, 00133 Principal Investigator: Fabrizio Clementi, MD. PhD Policlinico di Tor Vergata Recruiting Rome, Italy, 00133 Contact: Saverio Muscoli, MD +390620904009 fabrizio.clementi@me.com Principal Investigator: Fabrizio Clementi, MD, PhD Collapse << |
| NCT00732121 | Type 2 Diabetes | Phase 4 | Unknown | August 2010 | United States, Vermont ... more >> University of Vermont South Burlington, Vermont, United States, 05403 Collapse << |
| NCT00964106 | Drug Interactions | Phase 1 | Completed | - | Korea, Republic of ... more >> GSK Investigational Site Busan, Korea, Republic of, 614-735 GSK Investigational Site Seoul, Korea, Republic of, 110-744 Collapse << |
| NCT01408862 | - | - | Completed | - | - |
| NCT01408862 | - | - | Completed | - | - |
| NCT01909141 | Polycystic Ovary Syndrome ... more >> Infertility Collapse << | Early Phase 1 | Completed | - | Egypt ... more >> Cairo University Cairo, Egypt Collapse << |
| NCT00467285 | - | - | Completed | - | - |
| NCT00467285 | - | - | Completed | - | - |
| NCT02285205 | Type 2 Diabetes ... more >> Non-alcoholic Fatty Liver Disease Collapse << | Phase 4 | Completed | - | Korea, Republic of ... more >> Severance Hospital, Department of Internal Medicine, Yonsei University College of Medicine Seoul, Korea, Republic of, 120-752 Collapse << |
| NCT02341703 | Polycystic Ovary Syndrome ... more >> Infertility Collapse << | Early Phase 1 | Completed | - | Egypt ... more >> faculty of medicine, Cairo University Cairo, Egypt, 002 Collapse << |
| NCT01909141 | - | - | Completed | - | - |
| NCT00099853 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
| NCT00015626 | Insulin Resistance ... more >> Diabetes Mellitus Collapse << | Phase 2 | Completed | - | United States, New York ... more >> Cornell University New York, New York, United States, 10021 Collapse << |
| NCT01175486 | Diabetes | Phase 4 | Unknown | December 2015 | Taiwan ... more >> Taipei Veterans General Hospital, Taiwan Recruiting Taipei, Taiwan Principal Investigator: Harn-Shen Chen, MD, PhD Collapse << |
| NCT00357370 | - | - | Completed | - | - |
| NCT00364988 | Type 2 Diabetes ... more >> Diabetic Nephropathy Collapse << | Not Applicable | Completed | - | - |
| NCT00357370 | Type 2 Diabetes | Phase 2 Phase 3 | Completed | - | - |
| NCT00926016 | Chronic Hepatitis C | Not Applicable | Completed | - | United States, Texas ... more >> Brooke Army Medical Center San Antonio, Texas, United States, 78234 Collapse << |
| NCT00138554 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
| NCT00293137 | - | - | Terminated(safety concerns reg... more >>arding use of rosiglitazone) Collapse << | - | United States, Ohio ... more >> Cleveland Clinic Cleveland, Ohio, United States, 44195 Collapse << |
| NCT00745914 | Endstage Renal Disease ... more >> Diabetes Collapse << | Not Applicable | Completed | - | Hong Kong ... more >> Queen Mary Hospital and Tung Wah Hospital Hong Kong, Hong Kong, 0000 Queen Mary Hospital, Tung Wah Hospital Hong Kong, Hong Kong, 0000 Collapse << |
| NCT00359112 | Non-Insulin-Dependent Diabetes... more >> Mellitus Collapse << | Phase 3 | Completed | - | - |
| NCT00295633 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00680745 | Type 2 Diabetes | Phase 3 | Completed | - | - |
| NCT00295633 | - | - | Completed | - | - |
| NCT01055223 | - | - | Completed | - | - |
| NCT00396227 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
| NCT00680745 | - | - | Completed | - | - |
| NCT00742326 | - | - | Terminated(Enrollment stopped ... more >>prior to complete enrollment due to slow accrual) Collapse << | - | - |
| NCT01055223 | - | - | Completed | - | - |
| NCT00776607 | Latent Autoimmune Diabetes in ... more >>Adults LADA Collapse << | Not Applicable | Unknown | April 2011 | United Kingdom ... more >> Diabetes Unit Not yet recruiting Cardiff, Wales, United Kingdom, CF64 2XX Contact: Julia Platts 02920 711 711 ext 5149 Julia.Platts@CardiffandVale.wales.nhs.uk Principal Investigator: Julia Platts Clinical Research Unit Recruiting Swansea, Wales, United Kingdom, SA6 6NL Contact: Lucy Barlow +44 (0) 1792 703722 ext 3722 Lucy.Barlow@swansea-tr.wales.nhs.uk Principal Investigator: Jeffrey Stephens Collapse << |
| NCT00636766 | Carotid Atherosclerosis ... more >> Stroke Type 2 Diabetes Metabolic Syndrome Collapse << | Not Applicable | Completed | - | Greece ... more >> General Hospital of Thessaloniki "Hippokratio" Thessaloniki, Greece Collapse << |
| NCT00742326 | HIV Hepatitis... more >> C Liver Disease Fatty Liver Steatosis Collapse << | Phase 4 | Terminated(Enrollment stopped ... more >>prior to complete enrollment due to slow accrual) Collapse << | - | United States, District of Col... more >>umbia VA Medical Center Washington, District of Columbia, United States, 20422 United States, Maryland National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT00692510 | Metabolism Al... more >>zheimer's Disease Collapse << | Phase 1 | Completed | - | Sweden ... more >> Research Site Uppsala, Sweden Collapse << |
| NCT02737709 | Non-small Cell Lung Cancer | Phase 2 | Terminated(The study have diff... more >>iculty in recruiting subjectes) Collapse << | - | China, Guangdong ... more >> Sun Yat-sen University Cancer Center Guangzhou, Guangdong, China, 510060 Collapse << |
| NCT00437970 | Diabetes Mellitus, Type 2 | Phase 4 | Withdrawn(Unable to secure sup... more >>ply of the study medication) Collapse << | February 2009 | Australia, Northern Territory ... more >> Menzies School of Health Research Darwin, Northern Territory, Australia, 0810 Collapse << |
| NCT00232362 | Type 2 Diabetes Mellitus | Phase 1 | Withdrawn(This study was not c... more >>onducted as the Principal Investigator left the institution) Collapse << | June 2008 | - |
| NCT00443170 | Healthy Subjects ... more >> Anaemia Collapse << | Phase 1 | Completed | - | Australia, New South Wales ... more >> GSK Investigational Site Randwick, Sydney, New South Wales, Australia, 2031 Australia, Queensland GSK Investigational Site Herston, Queensland, Australia, 4006 Australia, South Australia GSK Investigational Site Adelaide, South Australia, Australia, 5000 Collapse << |
| 靶点 | Description | IC50 |
|---|---|---|
| PPARγ | Kd:43nM |
