|5-((3,4-二甲氧基苯乙基)(甲基)氨基)-2-(3,4-二甲氧基苯基)-2-异丙基戊腈盐酸盐|CsnPharm

CAS No.: 152-11-4

盐酸维拉帕米 Catalog No. CSN16652

Synonyms: (±)-Verapamil hydrochloride;CP-16533-1 hydrochloride;(±)-Verapamil HCl

Verapamil HCl is a phenylalkylamine class L-type calcium channel blocker.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Verapamil hydrochloride, a prototype calcium antagonist, is now marketed in the United States for the acute treatment of supraventricular tachyarrhythmias and for chronic management of vasospastic and chronic stable angina. It inhibits the slow inward channel in in the heart and blocks calcium influx in smooth muscle^[3]. Verapamil (hydrochloride) is an L-type calcium channel antagonist. The combination of Bortezomib and Verapamil (70 µM) markedly declines the viability of the JK-6L, RPMI 8226, and ARH-77 cell lines after 16 hours of culture^[4]. The enzyme hydrolase activity of recombinant human carboxylesterase (CES2) is substantially inhibited by Verapamil with Ki of 3.84±0.99μM^[5]. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Verapamil may confer an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein^[6]. Combined fractional CO2 laser and topical 5-FU (5-fluorouracil) or verapamil hydrochloride offer a safe therapy for HTSs (hypertrophic scars) and keloids^[7].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
A2780 cells	-	Function assay	-	Inhibition of P-gp in human adriamycin-resistant A2780 cells by Hoechst 33342 assay, IC50=4.57088 μM	18678495
Caco-2 cells	-	Function assay	-	Inhibition of Pgp measured as inhibition of [3H]vinblastine basolateral to apical transport in Caco-2 cells, EC50=20 μM	17064079
CCRF-CEM cells	5 μM	Function assay	-	The effective dose was measured against P-glycoprotein expressing CCRF-CEM cells in the presence of 5 uM daunomycin, ED50=0.045 μM	7629817

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临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00122304	Hemoglobinuria, Paroxysmal	Phase 3	Completed	-	-
NCT01363479	Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse <<	Phase 3	Completed	-	-
NCT01339260	Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse <<	Phase 3	Completed	-	-

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0364 mL
- 10.1820 mL
- 20.3640 mL
- 5 mM
- 0.4073 mL
- 2.0364 mL
- 4.0728 mL
- 10 mM
- 0.2036 mL
- 1.0182 mL
- 2.0364 mL

技术信息

CAS号

152-11-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H39ClN2O4

运输

蓝冰

分子量

491.06

别名

(±)-Verapamil hydrochloride;CP-16533-1 hydrochloride;(±)-Verapamil HCl;Verapamil (hydrochloride);NSC 272366;NSC 657799;(±)-Verapamil;Verapamil HCl;Calan;Cordilox;Dexverapamil;Falicard;Finoptin;Hydrochloride;Verapamil;Iproveratril;Isoptin;Isoptine;Izoptin;Lekoptin;盐酸维拉帕米

溶解度

DMSO	215.0 mg/mL (437.8 mM) warming
Water	90.0 mg/mL (183.3 mM)

动物实验配方

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

A2780 cells	-	Function assay	-	Inhibition of P-gp in human adriamycin-resistant A2780 cells by Hoechst 33342 assay, IC50=4.57088 μM	18678495
Caco-2 cells	-	Function assay	-	Inhibition of Pgp measured as inhibition of [3H]vinblastine basolateral to apical transport in Caco-2 cells, EC50=20 μM	17064079
CCRF-CEM cells	5 μM	Function assay	-	The effective dose was measured against P-glycoprotein expressing CCRF-CEM cells in the presence of 5 uM daunomycin, ED50=0.045 μM	7629817
CHO cells	-	Function assay	-	Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique, IC50=0.14125 μM	18448342
hamster BHK21 cells	-	Cytotoxic assay	96 h	Cytotoxicity against hamster BHK21 cells expressing MRP1 after 96 hrs by MTT assay, IC50=10.6 μM	20691599
HCT116/VM46 cell	1 μM	Function assay	-	Effect on vinblastine IC50 against MDR human carcinoma HCT116/VM46 cell line at a dose of 1 uM concentration, IC50=0.004 μM	12729663
human 2008 cells	-	Function assay	-	Inhibition of human MRP1 in human 2008 cells, IC50=9.66 μM	18707884
human CEM/VLB500 cells	-	Function assay	3 days	Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assay, EC50=1.041 μM	17399990
human H460 cells	50 μM	Function assay	72 h	Potentiation of erlotinib-induced cytotoxicity against human H460 cells assessed as erlotinib IC50 at 50 uM after 72 hrs by SRB assay, IC50=10.3 μM	25215856
human K562/DOX cells	-	Function assay	-	Modulatory activity at P-gp in human K562/DOX cells assessed as increase in nuclear concentration of pirarubicin by spectrofluorometric assay, IC50=1.6 μM	25282263
human KB/VCR cells	25 μM	Cytotoxic assay	72 h	Cytotoxicity against human KB/VCR cells assessed as vincristine IC50 at 25 uM after 72 hrs by SRB method, IC50=0.02 μM	25597010
human KB/VCR cells	-	Function assay	72 h	Inhibition of p-gp in human KB/VCR cells assessed as potentiation of 100 nM docetaxel-induced cytotoxicity after 72 hrs by MTT assay, EC50=1.253 μM	23683834
human KB31 cells	-	Cytotoxic assay	48 h	Cytotoxicity against human KB31 cells after 48 hrs by SRB method, IC50=45.2 μM	10346948
human KBV1 cells	-	Cytotoxic assay	48 h	Cytotoxicity against vinblastine resistant human KBV1 cells after 48 hrs in presence of 100 nM vinblastine by SRB method, IC50=1.6 μM	10346948
human KBV20C cells	-	Cytotoxic assay	-	Cytotoxicity against multidrug resistant P-gp expressing human KBV20C cells assessed as cell viability in presence of paclitaxel by MTS assay, IC50=0.01 μM	18295490
human KBV20C cells	-	Cytotoxic assay	-	Cytotoxicity against multidrug resistant P-gp expressing human KBV20C cells assessed as cell viability in presence of vincristine by MTS assay, IC50=0.2 μM	18295490
human LCC6MDR cells	-	Function assay	5 days	Reversal of P-gp-mediated doxorubicin-resistance in human LCC6MDR cells after 5 days by MTS assay, EC50=0.245 μM	22320402
human MCF7/ADR cells	10 μM	Function assay	48 h	Inhibition of P-gp in human MCF7/ADR cells assessed as reversal of multidrug resistance at 10 uM by measuring EC50 for adriamycin-induced cytotoxicity after 48 hrs by SRB colorimetric assay, EC50=4.89 μM	25856545
human NCI-H292 cells	50 μM	Function assay	72 h	Potentiation of erlotinib-induced cytotoxicity against human NCI-H292 cells assessed as erlotinib IC50 at 50 uM after 72 hrs by SRB assay, IC50=1.2 μM	25215856
K562 cells	3 μM	Function assay	72 h	Modulatory activity at P-gp assessed as doxorubicin IC50 in human K562 cells at 3 uM after 72 hrs by MTT assay (Rvb doxorubicin alone IC50 = 0.023 +/- 0.004 uM), IC50=0.029 μM	25282263
KB cells	-	Function assay	72 h	Inhibitory activity against KB cell line after 72 h of drug exposure, IC50=19.6 μM	15481991
KB-3-1 cells	5 μM	Function assay	68 h	Reversal of P-gp-mediated multidrug resistance to Cytotoxicity of colchicine against human KB-3-1 cells at 5 uM after 68 hrs by MTT assay, IC50=0.0047 μM	17488128
KB-C2 cells	5 μM	Function assay	68 h	Reversal of P-gp-mediated multidrug resistance to Cytotoxicity of colchicine against human KB-C2 cells at 5 uM after 68 hrs by MTT assay, IC50=0.1 μM	17488128
MCF7 cells	-	Function assay	-	Inhibition of human ERG in MCF7 cells, IC50=0.14454 μM	19110341
MDA435/LCC6 cells	-	Function assay	-	Reversal of vinblastine resistance in multidrug resistant MDA435/LCC6 cells by MTS assay, IC50=0.00025 μM	17154505
MDCK cells	-	Function assay	30 mins	Inhibition of human MDR1 expressed in MDCK cells assessed as calcein AM accumulation after 30 mins by fluorescence assay, IC50=0.5 μM	22112208
MDCK2 cells	-	Function assay	20 mins	Enhancement of calcein-AM uptake in MDCK2 cells over expressing MDR1 after 20 mins, EC50=5.1 μM	18849167
NCI-H292 cells	50 μM	Function assay	72 h	Potentiation of gefitinib-induced cytotoxicity against human NCI-H292 cells assessed as gefitinib IC50 at 50 uM after 72 hrs by SRB assay, IC50=0.18 μM	25215856
rat A7R5 cells	-	Function assay	15 mins	Antagonist activity at calcium channel in rat A7R5 cells assessed as inhibition of Cacl2/KCl-induced increase in intracellular Ca2+ incubated for 15 mins prior to Cacl2/KCl challenge by fluorescence assay, IC50=0.3 μM	25311564

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00122304	Hemoglobinuria, Paroxysmal	Phase 3	Completed	-	-
NCT01363479	Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse <<	Phase 3	Completed	-	-
NCT01339260	Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse <<	Phase 3	Completed	-	-
NCT01339260	-	-	Completed	-	-
NCT01363479	-	-	Completed	-	-
NCT01270828	Post Herpetic Neuralgia	Phase 3	Completed	-	-
NCT01270828	-	-	Completed	-	-
NCT00748787	Metabolic Syndrome	Phase 2	Terminated(It was very difficu... more >>lt to fulfill the inclusion criteria, therefore the expected time of inclusion was delayed so much time.) Collapse <<	-	Spain ... more >> Hospital Universitari San Joan de Reus Reus, Tarragona, Spain, 43201 Collapse <<
NCT01307267	Lymphoma, Non-Hodgkin ... more >> Lymphoma, Follicular Lymphoma, Large B-Cell, Diffuse Carcinoma, Non-Small-Cell Lung Carcinoma, Renal Cell Carcinoma, Squamous Cell of Head and Neck Malignant Melanoma Collapse <<	Phase 1	Active, not recruiting	March 2019	-
NCT01683175	Non-small Cell Lung Cancer Sta... more >>ge III Collapse <<	Phase 2	Active, not recruiting	October 2020	China, Tianjin ... more >> Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin, China, 300060 China Beijing Cancer Hospital Beijing, China Chinese PLA General Hospital Beijing, China The second people's hospital of Sichuan Chengdu, China Fujian Medical University Union Hospital Fuzhou, China Sun Yat-Sen University Cancer Center Guangzhou, China Zhejiang Cancer Hospital Hangzhou, China The third affiliated hospital of Harbin Medical Univer Harbin, China The affiliated hospital of medical college Qingdao University Qingdao, China Fudan University Shanghai Cancer Center Shanghai, China Zhongshan Hospital Fudan University Shanghai, China Liaoning Cancer Hospital & Institute Shenyang, China Hebei Provincial Tumor Hospital Shijiazhuang, China The first affiliated hospital of Soochow University Suzhou, China The fourth military medical university，Tangdu Hospital Xi'an, China Collapse <<
NCT02273375	Non-Small Cell Lung Cancer	Phase 3	Recruiting	-	-
NCT03071692	Type2 Diabetes ... more >> Dyslipidemia Collapse <<	Phase 3	Recruiting	May 2022	-
NCT03456063	Non-Small-Cell Lung	Phase 3	Recruiting	November 20, 2024	-
NCT03345849	Crohn's Disease	Phase 3	Recruiting	April 21, 2021	-
NCT01703780	-	-	Unknown	December 2018	China, Beijing ... more >> FuWai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing, Beijing, China, 100037 Xuanwu Hospital, Capital Medical University Beijing, Beijing, China, 100053 The general hospital of Chinese People's Liberation Army Beijing, Beijing, China, 100853 China, Fujian The First Affiliated Hospital of Fujian Medical University Fuzhou, Fujian, China, 350005 China, Guangdong Nanfang Hospital of southern medical university Guangzhou, Guangdong, China, 510515 China, Heilongjiang Hongxinglong Center Hospital Shuangyashan, Heilongjiang, China, 155811 China, Henan Henan Provincial People's Hospital Zhengzhou, Henan, China, 450000 China, Hubei TongJi Hospital, TongJi Medical Colleage, HuaZhong University of Science and Technology Wu Han, Hubei, China, 430000 China, Jiangsu The Third People's Hospital of Xuzhou Xuzhou, Jiangsu, China, 221005 China, Jilin The First Bethun Hospital of Jilin University Changchun, Jilin, China, 130012 China, Shandong Affiliated Hospital of Jining Medical University Jining, Shandong, China, 272000 Qingdao Municipal Hospital QingDao, Shandong, China, 266300 Rizhao Port Hospital Rizhao, Shandong, China, 276826 China, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, Shanghai, China, 200025 China, Shanxi First Hospital of Shanxi Medical University TaiYuan, Shanxi, China, 030001 The fourth military medical university Xi'an, Shanxi, China China, Sichuan West China Hospital，Sichuan Univer ChengDu, Sichuan, China, 610041 China, Tianjin Tianjin Chest Hospital Tianjin, Tianjin, China, 300051 Collapse <<
NCT02675426	Rheumatoid Arthritis	Phase 3	Active, not recruiting	August 6, 2020	-
NCT02706951	Rheumatoid Arthritis	Phase 3	Active, not recruiting	August 7, 2020	-
NCT02231749	Advanced Renal Cell Carcinoma ... more >> Metastatic Renal Cell Carcinoma Collapse <<	Phase 3	Active, not recruiting	September 30, 2019	-
NCT02988674	-	-	Active, not recruiting	November 30, 2019	Russian Federation ... more >> Kemerovo Regional Clinical Hospital n.a. S.V. Belyaev /ID# 167025 Kemerovo, Kemerovskaya Oblast, Russian Federation, 650066 Clinical Hospital No.1 n.a. N.I.Pirogov /ID# 154379 Moscow, Moskva, Russian Federation, 119049 Ivanovo Regional Clinical Hosp /ID# 167028 Ivanovo, Russian Federation, 153040 Institution KhMAO-Ugra /ID# 154381 Khanty-mansiysk, Russian Federation, 628011 State Clinical policlinic /ID# 154374 Moscow, Russian Federation, 107023 Central Research Institute /ID# 154375 Moscow, Russian Federation, 111123 Research Institute of Rheum /ID# 154378 Moscow, Russian Federation, 115522 Advisory-diagnostic Hospital /ID# 154382 Moscow, Russian Federation, 117041 State Clinical Hospital /ID# 154373 Moscow, Russian Federation, 119049 GBUZ Republican Hospital /ID# 167029 Petrozavodsk, Russian Federation, 185019 Smolensk station JSC Russian R /ID# 167027 Smolensk, Russian Federation, 214025 Nort-Western State Medical Uni /ID# 154376 St. Petersburg, Russian Federation, 191015 Tula Regional Clinical Hospita /ID# 155539 Tula, Russian Federation, 300053 Yaroslavi State Medical Univer /ID# 154383 Yaroslavl, Russian Federation, 150000 Collapse <<
NCT03345823	Crohn's Disease	Phase 3	Enrolling by invitation	March 22, 2023	-
NCT02265744	Lupus	Phase 2	Terminated(Inability to meet p... more >>rotocol objectives) Collapse <<	-	-
NCT02231749	-	-	Active, not recruiting	-	-
NCT02632409	Various Advanced Cancer	Phase 3	Recruiting	May 1, 2020	-
NCT02998528	Non Small Cell Lung Cancer	Phase 3	Recruiting	November 8, 2028	-
NCT03001882	Non-Small Cell Lung Cancer	Phase 2	Recruiting	December 14, 2021	-
NCT03036098	Urothelial Cancer	Phase 3	Recruiting	December 23, 2022	-
NCT02625623	Unresectable, Recurrent, Local... more >>ly Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Gastric Cancer Third Line Collapse <<	Phase 3	Active, not recruiting	September 30, 2022	-
NCT03345836	Crohn's Disease	Phase 3	Recruiting	April 15, 2020	-
NCT02654132	Multiple Myeloma	Phase 2	Active, not recruiting	April 22, 2019	-
NCT03519256	Bladder Cancer ... more >> Bladder Tumors Neoplasms, Bladder Collapse <<	Phase 2	Recruiting	April 16, 2023	-
NCT03192215	Stroke	Phase 3	Recruiting	April 30, 2022	-
NCT03215706	Non-Small Cell Lung Cancer	Phase 3	Recruiting	May 20, 2020	-
NCT00560651	-	-	Recruiting	November 2027	Germany ... more >> University of Saar Recruiting Homburg, Germany, 66421 Principal Investigator: Berthold Seitz, MD Sub-Investigator: Atilla Osvald, MD Augenklinik am St. Franziskus Hospital Recruiting Münster, Germany, 48145 Principal Investigator: Suphi Taneri, MD Sub-Investigator: Arnd Heiligenhaus, MD Collapse <<
NCT01983241	Pulmonary Emphysema in Alpha-1... more >> PI Deficiency Collapse <<	Phase 3	Recruiting	November 2023	-
NCT02563574	Alcohol Consumption ... more >> HIV Motivation Collapse <<	Not Applicable	Recruiting	December 2020	United States, Florida ... more >> University of Florida Recruiting Gainesville, Florida, United States, 32610 Contact: Megan A Forbes, B.S. 352-294-5844 meganforbes@phhp.ufl.edu Contact: Alissa Old Crow, M.Ed. alissaol@phhp.ufl.edu Sub-Investigator: Adam J. Woods, PhD Sub-Investigator: Eric Porges, PhD Sub-Investigator: Robert Cook, MD Sub-Investigator: Mingzhou Ding, PhD Sub-Investigator: Carla Mavian, PhD Sub-Investigator: Marco Salemi, PhD Sub-Investigator: Mattia Prosperi, PhD Florida International University Recruiting Miami, Florida, United States, 33199 Principal Investigator: Jessy Devieux, PhD Collapse <<
NCT02625623	-	-	Active, not recruiting	-	-
NCT00302211	-	-	Terminated(Terminated due to s... more >>low enrollment) Collapse <<	-	-
NCT00302211	Pulmonary Hypertension	Phase 3	Terminated(Terminated due to s... more >>low enrollment) Collapse <<	-	-
NCT00578617	Atrial Fibrillation ... more >> Arrhythmia Collapse <<	Not Applicable	Completed	-	United States, Alabama ... more >> Universtity of Alabama Hospital Birminham, Alabama, United States, 35233 United States, California Good Samaritan Hospital Los Angeles, California, United States, 90017 United States, Illinois Loyola University Maywood, Illinois, United States, 60626 United States, Iowa Mercy Medical Center Des Moines, Iowa, United States, 50314 United States, Maryland Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, Massachusetts Brigham and Womens Hospital Boston, Massachusetts, United States, 02115 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55902 United States, Ohio Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pennsylvania Health Philadelphia, Pennsylvania, United States, 19104 United States, Utah Intermountain Medical Center Murray, Utah, United States, 84157 Collapse <<
NCT00593463	Drug Dependence	Phase 1	Completed	-	United States, Arkansas ... more >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205 Collapse <<
NCT00733239	Opioid Dependence	Phase 1	Completed	-	United States, Arkansas ... more >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205 Collapse <<
NCT01873950	Drug-induced Surface ECG Chang... more >>es Collapse <<	Phase 1	Completed	-	-
NCT00578617	-	-	Completed	-	-
NCT01873950	-	-	Completed	-	-
NCT03061903	Wound Complication	Not Applicable	Recruiting	January 1, 2020	United States, New York ... more >> Hospital for Special Surgery Not yet recruiting New York, New York, United States, 10021 Contact: Zachary Berliner zackberliner@gmail.com Principal Investigator: Jose Rodriguez, MD Columbia University Medical Center Recruiting New York, New York, United States, 10023 Contact: Matthew Heller mh3818@cumc.columbia.edu Principal Investigator: Roshan P Shah, MD Canada, Ontario Humber River Hospital Not yet recruiting Toronto, Ontario, Canada, M3M 0B2 Contact: Iriss Mariano IMariano@hrh.ca Principal Investigator: Sebastian Rodriguez-Elizalde, MD Collapse <<
NCT00589303	Atrial Fibrillation ... more >> Heart Failure Collapse <<	Phase 3	Terminated(Lack of funding)	-	United States, Arizona ... more >> Mayo Clinic Arizona Scottsdale, Arizona, United States, 85259 United States, Indiana The Heart Group Evansville, Indiana, United States, 47710 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Tennessee Chattanooga Heart Institute Chattanooga, Tennessee, United States, 37404 Canada, Alberta University of Calgary and Calgary Health Region Calgary, Alberta, Canada, T2N-4N1 Collapse <<
NCT02248753	Atrial Fibrillation	Not Applicable	Active, not recruiting	October 2019	Netherlands ... more >> VU University Medical Center Amsterdam, Netherlands Amphia Hospital Breda, Netherlands Catharina Ziekenhuis Eindhoven, Netherlands Medisch Spectrum Twente Enschede, Netherlands University Medical Center Groningen Groningen, Netherlands Zuyderland Medical Center Heerlen, Netherlands Alrijne Hospital Leiderdorp, Netherlands Maastricht University Medical Center Maastricht, Netherlands St. Antonius Hospital Nieuwegein, Netherlands Franciscus Gasthuis Rotterdam, Netherlands Antonius Ziekenhuis Sneek, Netherlands HagaZiekenhuis The Hague, Netherlands St. Elisabeth - TweeSteden Hospital Tilburg, Netherlands Diakonessenhuis Utrecht, Netherlands VieCuri Medical Center Venlo, Netherlands Collapse <<
NCT03296800	Type 2 Diabetes Mellitus	Phase 1	Completed	-	United States, Florida ... more >> Covance Clinical Research Unit Daytona Beach, Florida, United States, 32117 Collapse <<
NCT01675362	Kidney Calculi	Phase 4	Completed	-	Egypt ... more >> Urology and Nephrology Center Mansoura, Egypt, 35516 Collapse <<
NCT01669304	Vestibular Migraine ... more >> Chronic Subjective Dizziness Collapse <<	Phase 1	Completed	-	United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse <<
NCT00589303	-	-	Terminated(Lack of funding)	-	-
NCT01127139	-	-	Completed	-	-
NCT00313157	Atrial Fibrillation	Phase 3	Completed	-	Norway ... more >> Vestre Viken Hospital Trust, Baerum Hospital Rud, Akershus, Norway, 1309 Collapse <<
NCT01127139	-	-	Completed	-	-
NCT02235558	Ischemic Stroke	Phase 1	Completed	-	United States, Kentucky ... more >> University of Kentucky Deparment of Neurosurgery, UK Chandler Hospital Lexington, Kentucky, United States, 40536 Collapse <<
NCT01607073	Dravet Syndrome	Phase 2	Completed	-	United States, Illinois ... more >> Children's Memorial Hospital Chicago, Illinois, United States, 60614 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Gillette Children's Specialty Healthcare St. Paul, Minnesota, United States, 55101 United States, New Hampshire Mary Hitchcock Memorial Hospital Lebanon, New Hampshire, United States, 03756 Collapse <<
NCT00707551	Healthy	Phase 1	Completed	-	Germany ... more >> Research Site Berlin, Germany Collapse <<
NCT01790113	Osteoarthritis	Not Applicable	Active, not recruiting	December 2020	United States, Arizona ... more >> Banner Research Sun City, Arizona, United States, 85351 United States, California Orthopedics Stanford University Redwood City, California, United States, 94063 United States, Colorado Western Orthopaedics Denver, Colorado, United States, 80218 United States, Illinois Midwest Orthopaedics at Rush Chicago, Illinois, United States, 60612 United States, Kentucky Ellis and Badenhausen Orthopedics PSC Louisville, Kentucky, United States, 40223 United States, Maryland Medstar Health Research Institute Hyattsville, Maryland, United States, 20782 Peninsula Orthopaedics Associates, P.A. Salisbury, Maryland, United States, 21804 United States, Minnesota Essentia Health Duluth Duluth, Minnesota, United States, 55805 United States, New York Excelsior Orthopedics Amherst, New York, United States, 14226 SUNY Upstate Medical Universtiy East Syracuse, New York, United States, 13057 United States, Ohio Adena Health System Chillicothe, Ohio, United States, 45601 OhioHealth Research Institute at Grant Medical Center Columbus, Ohio, United States, 43215 United States, Oregon Southern Oregon Orthopedics Medford, Oregon, United States, 97504 United States, Pennsylvania University Orthopedics Altoona, Pennsylvania, United States, 16602 Rothman Institute Philadelphia, Pennsylvania, United States, 19108 United States, South Carolina Palmetto Health Orthopedics (formerly Providence Orthopedics Group, LLC_Moore Orthopedics) Columbia, South Carolina, United States, 29203 Collapse <<
NCT03013933	Recurrent Hodgkin Lymphoma ... more >> Refractory Hodgkin Lymphoma CD30-Positive Neoplastic Cells Present Collapse <<	Phase 1	Recruiting	March 2019	United States, California ... more >> City of Hope Medical Center Recruiting Duarte, California, United States, 91010 Contact: Robert W. Chen, MD 626-256-4673 ext 64762 rchen@coh.org Principal Investigator: Robert W. Chen, MD Collapse <<
NCT00559169	Catamenial Epilepsy	Not Applicable	Withdrawn(protocol changed and... more >> a new study using verapamil in epilepsy will be started in the near future) Collapse <<	December 2010	Canada, Ontario ... more >> Toronto Western Hospital Toronto, Ontario, Canada, M5T 2S8 Collapse <<
NCT00168519	Diabetes Mellitus, Type 2	Not Applicable	Completed	-	Australia, Victoria ... more >> Baker Heart Research Institute Melbourne, Victoria, Australia, 8008 Collapse <<
NCT01126307	Epilepsy Seiz... more >>ures Collapse <<	Not Applicable	Unknown	December 2012	Canada, Ontario ... more >> Toronto Western Hospital Toronto, Ontario, Canada, M5T 2S8 Collapse <<
NCT02111317	Healthy Subjects ... more >> Pharmacokinetics of ASP015K Collapse <<	Phase 1	Completed	-	United States, California ... more >> PAREXEL Glendale, California, United States, 91206 Collapse <<
NCT03098680	Drug-Related Side Effects and ... more >>Adverse Reactions Cardiovascular System Disease Collapse <<	Phase 1	Recruiting	February 29, 2020	United Kingdom ... more >> Addenbrooke's Hospital Recruiting Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ Contact: Joseph Cheriyan, MBChB, MA, FRCP jc403@medschl.cam.ac.uk Collapse <<
NCT00668967	Healthy Volunteers	Phase 1	Completed	-	United States, Connecticut ... more >> Pfizer Investigational Site New Haven, Connecticut, United States, 06511 Collapse <<
NCT02454608	Sinusitis Nas... more >>al Polyps Collapse <<	Not Applicable	Terminated(Evidence that the d... more >>ose is insufficient.) Collapse <<	-	United States, Massachusetts ... more >> Massachusetts Eye and Ear Infirmary Boston, Massachusetts, United States, 02114 Collapse <<
NCT00983242	Pharmacokinetics	Phase 1	Completed	-	United States, Minnesota ... more >> PRACS Institute, Ltd. - Cetero Research East Grand Forks, Minnesota, United States, 56721 Collapse <<
NCT00133692	Hypertension ... more >>Coronary Artery Disease Collapse <<	Phase 4	Completed	-	United States, Florida ... more >> University of Florida Gainesville, Florida, United States, 32610-0277 Collapse <<
NCT00647673	Healthy	Phase 1	Completed	-	United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse <<
NCT00552565	Irritable Bowel Syndrome With ... more >>Diarrhea Collapse <<	Phase 3	Completed	-	United States, North Carolina ... more >> PPD Wilmington, North Carolina, United States, 28401 Collapse <<
NCT02454608	-	-	Terminated(Evidence that the d... more >>ose is insufficient.) Collapse <<	-	-
NCT03102190	Sinusitis Nas... more >>al Polyps Collapse <<	Phase 1 Phase 2	Recruiting	July 2019	United States, Massachusetts ... more >> Massachusetts Eye and Ear Recruiting Boston, Massachusetts, United States, 02114 Contact: Patricia Levesque 617-573-3576 patricia_levesque@meei.harvard.edu Principal Investigator: Benjamin S Bleier, MD Collapse <<
NCT00983242	-	-	Completed	-	-
NCT00648050	Healthy	Phase 1	Completed	-	United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse <<
NCT00649805	Healthy	Phase 1	Completed	-	United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse <<
NCT00648401	Healthy	Phase 1	Completed	-	United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse <<
NCT01467687	Healthy	Phase 1	Completed	-	-
NCT01471704	Healthy	Phase 1 Phase 2	Completed	-	United States, Minnesota ... more >> Prism Research, LLC St Paul, Minnesota, United States, 55114 Collapse <<
NCT02209155	Episodic Cluster Headache	Phase 2	Terminated	-	United Kingdom ... more >> UCLH/UCL NIHR Clinical Research Facility London, United Kingdom, NW1 2BU Collapse <<
NCT00748787	Metabolic Syndrome	Phase 2	Terminated(It was very difficu... more >>lt to fulfill the inclusion criteria, therefore the expected time of inclusion was delayed so much time.) Collapse <<	-	Spain ... more >> Hospital Universitari San Joan de Reus Reus, Tarragona, Spain, 43201 Collapse <<
NCT00122304	Hemoglobinuria, Paroxysmal	Phase 3	Completed	-	-
NCT01363479	Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse <<	Phase 3	Completed	-	-
NCT01270828	Post Herpetic Neuralgia	Phase 3	Completed	-	-
NCT01363479	-	-	Completed	-	-
NCT01270828	-	-	Completed	-	-
NCT02273375	Non-Small Cell Lung Cancer	Phase 3	Recruiting	-	-
NCT01339260	Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse <<	Phase 3	Completed	-	-
NCT03071692	Type2 Diabetes ... more >> Dyslipidemia Collapse <<	Phase 3	Recruiting	May 2022	-
NCT01339260	-	-	Completed	-	-
NCT01307267	Lymphoma, Non-Hodgkin ... more >> Lymphoma, Follicular Lymphoma, Large B-Cell, Diffuse Carcinoma, Non-Small-Cell Lung Carcinoma, Renal Cell Carcinoma, Squamous Cell of Head and Neck Malignant Melanoma Collapse <<	Phase 1	Active, not recruiting	March 2019	-
NCT03345836	Crohn's Disease	Phase 3	Recruiting	April 15, 2020	-
NCT01683175	Non-small Cell Lung Cancer Sta... more >>ge III Collapse <<	Phase 2	Active, not recruiting	October 2020	China, Tianjin ... more >> Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin, China, 300060 China Beijing Cancer Hospital Beijing, China Chinese PLA General Hospital Beijing, China The second people's hospital of Sichuan Chengdu, China Fujian Medical University Union Hospital Fuzhou, China Sun Yat-Sen University Cancer Center Guangzhou, China Zhejiang Cancer Hospital Hangzhou, China The third affiliated hospital of Harbin Medical Univer Harbin, China The affiliated hospital of medical college Qingdao University Qingdao, China Fudan University Shanghai Cancer Center Shanghai, China Zhongshan Hospital Fudan University Shanghai, China Liaoning Cancer Hospital & Institute Shenyang, China Hebei Provincial Tumor Hospital Shijiazhuang, China The first affiliated hospital of Soochow University Suzhou, China The fourth military medical university，Tangdu Hospital Xi'an, China Collapse <<
NCT03456063	Non-Small-Cell Lung	Phase 3	Recruiting	November 20, 2024	-
NCT01703780	-	-	Unknown	December 2018	China, Beijing ... more >> FuWai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing, Beijing, China, 100037 Xuanwu Hospital, Capital Medical University Beijing, Beijing, China, 100053 The general hospital of Chinese People's Liberation Army Beijing, Beijing, China, 100853 China, Fujian The First Affiliated Hospital of Fujian Medical University Fuzhou, Fujian, China, 350005 China, Guangdong Nanfang Hospital of southern medical university Guangzhou, Guangdong, China, 510515 China, Heilongjiang Hongxinglong Center Hospital Shuangyashan, Heilongjiang, China, 155811 China, Henan Henan Provincial People's Hospital Zhengzhou, Henan, China, 450000 China, Hubei TongJi Hospital, TongJi Medical Colleage, HuaZhong University of Science and Technology Wu Han, Hubei, China, 430000 China, Jiangsu The Third People's Hospital of Xuzhou Xuzhou, Jiangsu, China, 221005 China, Jilin The First Bethun Hospital of Jilin University Changchun, Jilin, China, 130012 China, Shandong Affiliated Hospital of Jining Medical University Jining, Shandong, China, 272000 Qingdao Municipal Hospital QingDao, Shandong, China, 266300 Rizhao Port Hospital Rizhao, Shandong, China, 276826 China, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, Shanghai, China, 200025 China, Shanxi First Hospital of Shanxi Medical University TaiYuan, Shanxi, China, 030001 The fourth military medical university Xi'an, Shanxi, China China, Sichuan West China Hospital，Sichuan Univer ChengDu, Sichuan, China, 610041 China, Tianjin Tianjin Chest Hospital Tianjin, Tianjin, China, 300051 Collapse <<
NCT02706951	Rheumatoid Arthritis	Phase 3	Active, not recruiting	August 7, 2020	-
NCT02675426	Rheumatoid Arthritis	Phase 3	Active, not recruiting	August 6, 2020	-
NCT03345823	Crohn's Disease	Phase 3	Enrolling by invitation	March 22, 2023	-
NCT02231749	Advanced Renal Cell Carcinoma ... more >> Metastatic Renal Cell Carcinoma Collapse <<	Phase 3	Active, not recruiting	September 30, 2019	-
NCT03345849	Crohn's Disease	Phase 3	Recruiting	April 21, 2021	-
NCT02231749	-	-	Active, not recruiting	-	-
NCT02654132	Multiple Myeloma	Phase 2	Active, not recruiting	April 22, 2019	-
NCT02265744	Lupus	Phase 2	Terminated(Inability to meet p... more >>rotocol objectives) Collapse <<	-	-
NCT02988674	-	-	Active, not recruiting	November 30, 2019	Russian Federation ... more >> Kemerovo Regional Clinical Hospital n.a. S.V. Belyaev /ID# 167025 Kemerovo, Kemerovskaya Oblast, Russian Federation, 650066 Clinical Hospital No.1 n.a. N.I.Pirogov /ID# 154379 Moscow, Moskva, Russian Federation, 119049 Ivanovo Regional Clinical Hosp /ID# 167028 Ivanovo, Russian Federation, 153040 Institution KhMAO-Ugra /ID# 154381 Khanty-mansiysk, Russian Federation, 628011 State Clinical policlinic /ID# 154374 Moscow, Russian Federation, 107023 Central Research Institute /ID# 154375 Moscow, Russian Federation, 111123 Research Institute of Rheum /ID# 154378 Moscow, Russian Federation, 115522 Advisory-diagnostic Hospital /ID# 154382 Moscow, Russian Federation, 117041 State Clinical Hospital /ID# 154373 Moscow, Russian Federation, 119049 GBUZ Republican Hospital /ID# 167029 Petrozavodsk, Russian Federation, 185019 Smolensk station JSC Russian R /ID# 167027 Smolensk, Russian Federation, 214025 Nort-Western State Medical Uni /ID# 154376 St. Petersburg, Russian Federation, 191015 Tula Regional Clinical Hospita /ID# 155539 Tula, Russian Federation, 300053 Yaroslavi State Medical Univer /ID# 154383 Yaroslavl, Russian Federation, 150000 Collapse <<
NCT02632409	Various Advanced Cancer	Phase 3	Recruiting	May 1, 2020	-
NCT03001882	Non-Small Cell Lung Cancer	Phase 2	Recruiting	December 14, 2021	-
NCT02998528	Non Small Cell Lung Cancer	Phase 3	Recruiting	November 8, 2028	-
NCT03036098	Urothelial Cancer	Phase 3	Recruiting	December 23, 2022	-
NCT02625623	-	-	Active, not recruiting	-	-
NCT02625623	Unresectable, Recurrent, Local... more >>ly Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Gastric Cancer Third Line Collapse <<	Phase 3	Active, not recruiting	September 30, 2022	-
NCT01983241	Pulmonary Emphysema in Alpha-1... more >> PI Deficiency Collapse <<	Phase 3	Recruiting	November 2023	-
NCT03519256	Bladder Cancer ... more >> Bladder Tumors Neoplasms, Bladder Collapse <<	Phase 2	Recruiting	April 16, 2023	-
NCT03215706	Non-Small Cell Lung Cancer	Phase 3	Recruiting	May 20, 2020	-
NCT00560651	-	-	Recruiting	November 2027	Germany ... more >> University of Saar Recruiting Homburg, Germany, 66421 Principal Investigator: Berthold Seitz, MD Sub-Investigator: Atilla Osvald, MD Augenklinik am St. Franziskus Hospital Recruiting Münster, Germany, 48145 Principal Investigator: Suphi Taneri, MD Sub-Investigator: Arnd Heiligenhaus, MD Collapse <<
NCT03192215	Stroke	Phase 3	Recruiting	April 30, 2022	-
NCT02563574	Alcohol Consumption ... more >> HIV Motivation Collapse <<	Not Applicable	Recruiting	December 2020	United States, Florida ... more >> University of Florida Recruiting Gainesville, Florida, United States, 32610 Contact: Megan A Forbes, B.S. 352-294-5844 meganforbes@phhp.ufl.edu Contact: Alissa Old Crow, M.Ed. alissaol@phhp.ufl.edu Sub-Investigator: Adam J. Woods, PhD Sub-Investigator: Eric Porges, PhD Sub-Investigator: Robert Cook, MD Sub-Investigator: Mingzhou Ding, PhD Sub-Investigator: Carla Mavian, PhD Sub-Investigator: Marco Salemi, PhD Sub-Investigator: Mattia Prosperi, PhD Florida International University Recruiting Miami, Florida, United States, 33199 Principal Investigator: Jessy Devieux, PhD Collapse <<
NCT00302211	Pulmonary Hypertension	Phase 3	Terminated(Terminated due to s... more >>low enrollment) Collapse <<	-	-
NCT00593463	Drug Dependence	Phase 1	Completed	-	United States, Arkansas ... more >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205 Collapse <<
NCT00302211	-	-	Terminated(Terminated due to s... more >>low enrollment) Collapse <<	-	-
NCT00733239	Opioid Dependence	Phase 1	Completed	-	United States, Arkansas ... more >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205 Collapse <<
NCT00578617	-	-	Completed	-	-
NCT03296800	Type 2 Diabetes Mellitus	Phase 1	Completed	-	United States, Florida ... more >> Covance Clinical Research Unit Daytona Beach, Florida, United States, 32117 Collapse <<
NCT00589303	-	-	Terminated(Lack of funding)	-	-
NCT00589303	Atrial Fibrillation ... more >> Heart Failure Collapse <<	Phase 3	Terminated(Lack of funding)	-	United States, Arizona ... more >> Mayo Clinic Arizona Scottsdale, Arizona, United States, 85259 United States, Indiana The Heart Group Evansville, Indiana, United States, 47710 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Tennessee Chattanooga Heart Institute Chattanooga, Tennessee, United States, 37404 Canada, Alberta University of Calgary and Calgary Health Region Calgary, Alberta, Canada, T2N-4N1 Collapse <<
NCT00578617	Atrial Fibrillation ... more >> Arrhythmia Collapse <<	Not Applicable	Completed	-	United States, Alabama ... more >> Universtity of Alabama Hospital Birminham, Alabama, United States, 35233 United States, California Good Samaritan Hospital Los Angeles, California, United States, 90017 United States, Illinois Loyola University Maywood, Illinois, United States, 60626 United States, Iowa Mercy Medical Center Des Moines, Iowa, United States, 50314 United States, Maryland Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, Massachusetts Brigham and Womens Hospital Boston, Massachusetts, United States, 02115 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55902 United States, Ohio Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pennsylvania Health Philadelphia, Pennsylvania, United States, 19104 United States, Utah Intermountain Medical Center Murray, Utah, United States, 84157 Collapse <<
NCT02248753	Atrial Fibrillation	Not Applicable	Active, not recruiting	October 2019	Netherlands ... more >> VU University Medical Center Amsterdam, Netherlands Amphia Hospital Breda, Netherlands Catharina Ziekenhuis Eindhoven, Netherlands Medisch Spectrum Twente Enschede, Netherlands University Medical Center Groningen Groningen, Netherlands Zuyderland Medical Center Heerlen, Netherlands Alrijne Hospital Leiderdorp, Netherlands Maastricht University Medical Center Maastricht, Netherlands St. Antonius Hospital Nieuwegein, Netherlands Franciscus Gasthuis Rotterdam, Netherlands Antonius Ziekenhuis Sneek, Netherlands HagaZiekenhuis The Hague, Netherlands St. Elisabeth - TweeSteden Hospital Tilburg, Netherlands Diakonessenhuis Utrecht, Netherlands VieCuri Medical Center Venlo, Netherlands Collapse <<
NCT02235558	Ischemic Stroke	Phase 1	Completed	-	United States, Kentucky ... more >> University of Kentucky Deparment of Neurosurgery, UK Chandler Hospital Lexington, Kentucky, United States, 40536 Collapse <<
NCT01675362	Kidney Calculi	Phase 4	Completed	-	Egypt ... more >> Urology and Nephrology Center Mansoura, Egypt, 35516 Collapse <<
NCT01873950	Drug-induced Surface ECG Chang... more >>es Collapse <<	Phase 1	Completed	-	-
NCT00313157	Atrial Fibrillation	Phase 3	Completed	-	Norway ... more >> Vestre Viken Hospital Trust, Baerum Hospital Rud, Akershus, Norway, 1309 Collapse <<
NCT01669304	Vestibular Migraine ... more >> Chronic Subjective Dizziness Collapse <<	Phase 1	Completed	-	United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse <<
NCT03061903	Wound Complication	Not Applicable	Recruiting	January 1, 2020	United States, New York ... more >> Hospital for Special Surgery Not yet recruiting New York, New York, United States, 10021 Contact: Zachary Berliner zackberliner@gmail.com Principal Investigator: Jose Rodriguez, MD Columbia University Medical Center Recruiting New York, New York, United States, 10023 Contact: Matthew Heller mh3818@cumc.columbia.edu Principal Investigator: Roshan P Shah, MD Canada, Ontario Humber River Hospital Not yet recruiting Toronto, Ontario, Canada, M3M 0B2 Contact: Iriss Mariano IMariano@hrh.ca Principal Investigator: Sebastian Rodriguez-Elizalde, MD Collapse <<
NCT01790113	Osteoarthritis	Not Applicable	Active, not recruiting	December 2020	United States, Arizona ... more >> Banner Research Sun City, Arizona, United States, 85351 United States, California Orthopedics Stanford University Redwood City, California, United States, 94063 United States, Colorado Western Orthopaedics Denver, Colorado, United States, 80218 United States, Illinois Midwest Orthopaedics at Rush Chicago, Illinois, United States, 60612 United States, Kentucky Ellis and Badenhausen Orthopedics PSC Louisville, Kentucky, United States, 40223 United States, Maryland Medstar Health Research Institute Hyattsville, Maryland, United States, 20782 Peninsula Orthopaedics Associates, P.A. Salisbury, Maryland, United States, 21804 United States, Minnesota Essentia Health Duluth Duluth, Minnesota, United States, 55805 United States, New York Excelsior Orthopedics Amherst, New York, United States, 14226 SUNY Upstate Medical Universtiy East Syracuse, New York, United States, 13057 United States, Ohio Adena Health System Chillicothe, Ohio, United States, 45601 OhioHealth Research Institute at Grant Medical Center Columbus, Ohio, United States, 43215 United States, Oregon Southern Oregon Orthopedics Medford, Oregon, United States, 97504 United States, Pennsylvania University Orthopedics Altoona, Pennsylvania, United States, 16602 Rothman Institute Philadelphia, Pennsylvania, United States, 19108 United States, South Carolina Palmetto Health Orthopedics (formerly Providence Orthopedics Group, LLC_Moore Orthopedics) Columbia, South Carolina, United States, 29203 Collapse <<
NCT01127139	-	-	Completed	-	-
NCT01127139	-	-	Completed	-	-
NCT03013933	Recurrent Hodgkin Lymphoma ... more >> Refractory Hodgkin Lymphoma CD30-Positive Neoplastic Cells Present Collapse <<	Phase 1	Recruiting	March 2019	United States, California ... more >> City of Hope Medical Center Recruiting Duarte, California, United States, 91010 Contact: Robert W. Chen, MD 626-256-4673 ext 64762 rchen@coh.org Principal Investigator: Robert W. Chen, MD Collapse <<
NCT00552565	Irritable Bowel Syndrome With ... more >>Diarrhea Collapse <<	Phase 3	Completed	-	United States, North Carolina ... more >> PPD Wilmington, North Carolina, United States, 28401 Collapse <<
NCT01607073	Dravet Syndrome	Phase 2	Completed	-	United States, Illinois ... more >> Children's Memorial Hospital Chicago, Illinois, United States, 60614 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Gillette Children's Specialty Healthcare St. Paul, Minnesota, United States, 55101 United States, New Hampshire Mary Hitchcock Memorial Hospital Lebanon, New Hampshire, United States, 03756 Collapse <<
NCT03098680	Drug-Related Side Effects and ... more >>Adverse Reactions Cardiovascular System Disease Collapse <<	Phase 1	Recruiting	February 29, 2020	United Kingdom ... more >> Addenbrooke's Hospital Recruiting Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ Contact: Joseph Cheriyan, MBChB, MA, FRCP jc403@medschl.cam.ac.uk Collapse <<
NCT00707551	Healthy	Phase 1	Completed	-	Germany ... more >> Research Site Berlin, Germany Collapse <<
NCT00559169	Catamenial Epilepsy	Not Applicable	Withdrawn(protocol changed and... more >> a new study using verapamil in epilepsy will be started in the near future) Collapse <<	December 2010	Canada, Ontario ... more >> Toronto Western Hospital Toronto, Ontario, Canada, M5T 2S8 Collapse <<
NCT01126307	Epilepsy Seiz... more >>ures Collapse <<	Not Applicable	Unknown	December 2012	Canada, Ontario ... more >> Toronto Western Hospital Toronto, Ontario, Canada, M5T 2S8 Collapse <<
NCT00668967	Healthy Volunteers	Phase 1	Completed	-	United States, Connecticut ... more >> Pfizer Investigational Site New Haven, Connecticut, United States, 06511 Collapse <<
NCT02454608	Sinusitis Nas... more >>al Polyps Collapse <<	Not Applicable	Terminated(Evidence that the d... more >>ose is insufficient.) Collapse <<	-	United States, Massachusetts ... more >> Massachusetts Eye and Ear Infirmary Boston, Massachusetts, United States, 02114 Collapse <<
NCT01873950	-	-	Completed	-	-
NCT03102190	Sinusitis Nas... more >>al Polyps Collapse <<	Phase 1 Phase 2	Recruiting	July 2019	United States, Massachusetts ... more >> Massachusetts Eye and Ear Recruiting Boston, Massachusetts, United States, 02114 Contact: Patricia Levesque 617-573-3576 patricia_levesque@meei.harvard.edu Principal Investigator: Benjamin S Bleier, MD Collapse <<
NCT00133692	Hypertension ... more >>Coronary Artery Disease Collapse <<	Phase 4	Completed	-	United States, Florida ... more >> University of Florida Gainesville, Florida, United States, 32610-0277 Collapse <<
NCT02209155	Episodic Cluster Headache	Phase 2	Terminated	-	United Kingdom ... more >> UCLH/UCL NIHR Clinical Research Facility London, United Kingdom, NW1 2BU Collapse <<
NCT02111317	Healthy Subjects ... more >> Pharmacokinetics of ASP015K Collapse <<	Phase 1	Completed	-	United States, California ... more >> PAREXEL Glendale, California, United States, 91206 Collapse <<
NCT00983242	Pharmacokinetics	Phase 1	Completed	-	United States, Minnesota ... more >> PRACS Institute, Ltd. - Cetero Research East Grand Forks, Minnesota, United States, 56721 Collapse <<
NCT00168519	Diabetes Mellitus, Type 2	Not Applicable	Completed	-	Australia, Victoria ... more >> Baker Heart Research Institute Melbourne, Victoria, Australia, 8008 Collapse <<
NCT02454608	-	-	Terminated(Evidence that the d... more >>ose is insufficient.) Collapse <<	-	-
NCT01467687	Healthy	Phase 1	Completed	-	-
NCT00983242	-	-	Completed	-	-
NCT00649805	Healthy	Phase 1	Completed	-	United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse <<
NCT00648401	Healthy	Phase 1	Completed	-	United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse <<
NCT00647673	Healthy	Phase 1	Completed	-	United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse <<
NCT00648050	Healthy	Phase 1	Completed	-	United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse <<
NCT01471704	Healthy	Phase 1 Phase 2	Completed	-	United States, Minnesota ... more >> Prism Research, LLC St Paul, Minnesota, United States, 55114 Collapse <<

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