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CAS No.: 52-53-9

维拉帕米 Catalog No. CSN25647

Synonyms: 维拉帕米;(±)-Verapamil;CP-16533-1

Verapamil is a phenylalkylamine class L-type calcium channel blocker. It may be a potential Covid-19 drug.

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技术信息

生物活性

描述Verapamil is a calcium channel blocker. Intravenous verapamil is highly effective in the termination of paroxysmal reciprocating atrioventricular tachycardia, whether associated with preexcitation or involving the atrioventricular node alone. Given orally it is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation^[4]. The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM^[5]. Approximately 80 percent of patients with PSVT will convert to normal sinus rhythm after verapamil 0.075-0.15 mg/kg. Atrial fibrillation and flutter seldom convert to sinus rhythm with verapamil, but it successfully reduces the ventricular rate in 90 percent of these patients. Verapamil is useful for the rapid conversion of PSVT to normal sinus rhythm and for the rapid control of ventricular rate in atrial fibrillation and flutter before other antiarrhythmics have taken effect^[6]. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1997 mL
- 10.9987 mL
- 21.9974 mL
- 5 mM
- 0.4399 mL
- 2.1997 mL
- 4.3995 mL
- 10 mM
- 0.2200 mL
- 1.0999 mL
- 2.1997 mL

技术信息

CAS号

52-53-9

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H38N2O4

运输

蓝冰

分子量

454.60

别名

维拉帕米;(±)-Verapamil;CP-16533-1

溶解度

DMSO	215.0 mg/mL (472.9 mM)
Water	insoluble

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